ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2015, Vol. 7 ›› Issue (5): 430-433.doi: 10.3969/j.issn.1674-3865.2015.05.007

• 临床研究 • 上一篇    下一篇

降钙素原在儿童发热性疾病初始治疗中指导抗生素使用的意义

萨日娜,王爱琼   

  1. 017000 内蒙古 鄂尔多斯,鄂尔多斯市中心医院儿科
  • 出版日期:2015-10-25 发布日期:2015-11-19
  • 通讯作者: 王爱琼,017000 内蒙古 鄂尔多斯,鄂尔多斯市中心医院儿科。
  • 作者简介:萨日娜(1984-),女,医学硕士,主治医师。研究方向:小儿呼吸系统疾病的诊治。

Significance of serum procalcitonin in guiding the use of antibiotics in the early treatment for febrile disease in children

SA Rina, WANG Aiqiong   

  1. Inner Mongolia Erdos Central Hospital, Erdos 017000,China
  • Online:2015-10-25 Published:2015-11-19

摘要:
目的
:探讨血清降钙素原在儿童发热性疾病中指导抗生素使用的临床意义。
方法:分析304例发热患儿病例资料,观察组152例,入院时均检测血清降钙素原水平,初始治疗过程中是否使用抗生素依据降钙素原水平,降钙素原≥0.25 μg/L时予以抗生素治疗。对照组152例,未检测降钙素原水平,经验性使用抗生素。观察两组患儿退热时间、住院时间、抗生素使用率和出院转归预后情况。
结果:观察组抗生素使用率为61.2%(93/152),显著低于对照组92.1%(140/152),差异有统计学意义(P<0.05),两组间退热时间、住院时间及预后比较差异无统计学意义(P>0.05)。
结论:降钙素原在儿童发热性疾病中早期预测细菌感染及指导抗生素治疗中有重要意义。

关键词: 发热, 降钙素原, 抗生素, 儿童

Abstract:
Objective:
To study the clinical significance of procalcitonin in guiding the use of the antibiotics in the treatment for children with febrile disease.
Methods:Analyse the clinical data of 304 children who suffered from febrile disease. In the observation group(n=152),serum PCT level was measured at admission,and antibiotic treatment was based on serum procalcitonin in the initial treatment process;we use the antibiotics when PCT≥0.25 μg/L.In the control group(n=152) the PCT had not been detected,so the use of the antibiotics was based on experience.Observe the time of fever recession,hospital stay,rate of antibiotics use and the prognosis.
Results:The rate of antibiotic use in observation group(61.2%,93/152) was significantly lower than that of the control group(92.1%,140/152),and the time of fever recession,hospitalization days and prognosis in two groups had no significant difference (P>0.05).
Conclusion:PCT has important significance in early prediction of bacterial infection and guiding antibiotic therapy in children with febrile diseases.

Key words: fever, procalcitonin, antibiotics, children

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