ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2015, Vol. 7 ›› Issue (5): 478-481.doi: 10.3969/j.issn.1674-3865.2015.05.025

• 临床研究 • 上一篇    下一篇

EB病毒感染所致传染性单核细胞增多症55例分析

王云丽,薛建芳   

  1. 014040 内蒙古 包头,包头市中心医院儿科
  • 出版日期:2015-10-25 发布日期:2015-11-19
  • 作者简介:王云丽(1975-),女,副主任医师。研究方向:小儿感染性疾病的诊治。

Retrospective analysis of 55 cases of Epstein-Barr virus-associated infectious mononucleosis

WANG Yunli,XUE Janfang   

  1. Pediatric Department Baotou City Center Hospital,Baotou 014040,China.
  • Online:2015-10-25 Published:2015-11-19

摘要:
目的
:总结小儿传染性单核细胞增多症的临床特征,以得到早期诊断及治疗。
方法:收集符合EBV感染的传染性单核细胞增多症55例,进行回顾性分析。
结果:本病的临床表现主要为:发热98.2%(54/55);咽峡炎100%(55/55);淋巴结肿大87.2%(48/55);肝脏肿大32.7%(18/55);脾脏肿大49.1%(27/55);双眼睑水肿54.5%(30/55);鼻塞29.0%(16/55);皮疹23.6%(13/55)。实验室检查:外周血常规白细胞数>10×109/L者96%(53/55);EBV-DNA检测均阳性,可伴肝功能受损、心肌损害、肺炎等,更昔洛韦治疗有效。
结论:传染性单核细胞增多症临床表现复杂多样,可伴多器官多系统损害,大多预后良好。EBV-DNA检测具有特异性,可提高对本病的早期诊断。更昔洛韦治疗有效。

关键词: 传染性单核细胞增多症/治疗, 更昔洛韦/治疗应用, 儿童

Abstract:
Objective:
To sum up the clinical characteristics of infectious mononucleosis in children in order to get early diagnosis and treatment.
Methods:A retrospective analysis of 55 cases of infectious mononycleosis by EBV infection in our hospital was carried out.
Results:The clinical manifestations of the disease mainly were: fever 98.2% (54/55),angina 100% (55/55),lymph node enlargement 87.2% (48/55),liver enlargement 32.7% (18/55),splenomegaly 49.1% (27/55),eyelid edema 54.5% (30/55),nasal obstruction 29.0% (16/55),and rash 23.6% (13/55). Laboratory examination: peripheral blood white blood cell count was greater than 10×109/L in 96% (53/55); EBV-DNA was positive in all cases, with liver function damage, myocardial damage, or pneumonia. Ganciclovir treatment was effective.
Conclusion:The clinical manifestations of infectious mononucleosis are complex and diverse, which can be complicated with multiple organ damage, but most of the prognosis is good. EBV-DNA detection has specificity, which can improve the early diagnosis of the disease. Ganciclovir treatment is effective.

Key words: infectious mononucleosis/therapy, ganciclovir/therapeutic use, children

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