ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2015, Vol. 7 ›› Issue (5): 494-497.doi: 10.3969/j.issn.1674-3865.2015.05.031

• 临床研究 • 上一篇    下一篇

脑钠肽对婴幼儿重症肺炎合并心力衰竭的诊断价值

何雷锋,杨英,刘中奇,谭润果,王景会,杜秋萍,陈香红   

  1. 450004 郑州,郑州市第一人民医院儿科二病区
  • 出版日期:2015-10-25 发布日期:2015-11-19
  • 作者简介:何雷锋(1983-),男,医学硕士,主治医师。研究方向：小儿呼吸系统疾病的防治，E-mail：hlf199@126.com。

The diagnostic value of brain natriuretic peptide (BNP) in infants with severe pneumonia complicated with heart failure

HE Leifeng, YANG Ying, LIU Zhongqi, TAN Runguo, WANG Jinghui, DU Qiuping, CHEN Xianghong   

  1. Zhengzhou First People's Hospital,Zhengzhou 450004,China.
  • Online:2015-10-25 Published:2015-11-19

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摘要： 目的 总结脑钠肽(BNP)对婴幼儿重症肺炎合并心力衰竭的诊断价值。方法 对临床诊断为普通肺炎的100例患儿(A组)、100例重症肺炎合并心衰患儿(B组)、80例重症肺炎患儿(无心力衰竭)(C组)的实验室检查结果进行回顾性分析。结果 3组患儿在肌酸激酶(CK)、肌酸激酶同功酶(CKMB)、肌钙蛋白(CTNI)、BNP异常率上有显著性差异(P＜0.01),进一步组间比较显示其中A组与B组的血清CK、CKMB、CTNI、BNP异常率均有明显差异(P＜0.01)；A组与C组的血清BNP异常率无明显差异(P＞0.05),CK、CKMB、CTNI异常率有明显差异(P＜0.01)；B组与C组的CK、CKMB、CTNI异常率无明显差异(P＞0.05),BNP异常率有明显差异(P＜0.01)；B组患儿于心衰纠正后复查BNP均恢复正常范围。结论 BNP为婴幼儿重症肺炎合并心力衰竭的敏感性、特异性客观标志物。

关键词: 肺炎/并发症, 心力衰竭/并发症, 脑钠肽/治疗应用, 儿童

Abstract: ObjectiveTo summarize the value of brain natriuretic peptide (BNP) in the diagnosis of severe pneumonia complicated with heart failure in infants.MethodsIn 100 cases of children clinically diagnosed with common pneumonia (group A) and 100 cases of children with severe pneumonia complicated with heart failure (group B)and 80 cases of children with severe pneumonia (no heart failure) group (C),the laboratory results were retrospectively analyzed.ResultsIn the three groups of children the abnormal rate of CK, CKMB (creatine kinase, creatine kinase isoenzyme), CTNI (troponin) and BNP had significant difference (P＜0.01); further comparison showed that befween group A and group B serum CK, CKMB, CTNI and BNP were significantly different (P＜0.01)in abnormal rate; between group A and group C abnormal rate of serum BNP had no obvious difference (P＞0.05), but abnormal rate of CK, CKMB and CTNI of had obvious difference (P＜0.01); between group B and group C abnormal rate of CK, CKMB and CTNI had no significant difference (P＞0.05), but abnormal rate of BNP had obvious difference (P＜0.01); in group B, after heart failure was corrected, BNP was restored to normal range.ConclusionBNP is a sensitive and special objective marker for infants with severe pneumonia complicated with heart failure.

Key words: pneumonia/complication, heart failure/complication, BNP/treatment application, children

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