ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2015, Vol. 7 ›› Issue (5): 497-500.doi: 10.3969/j.issn.1674-3865.2015.05.032

• 临床研究 • 上一篇    下一篇

儿童肾病综合征D二聚体和抗凝血酶检测的临床意义

王学盛   

  1. 116400 辽宁 庄河,庄河市中心医院检验科
  • 出版日期:2015-10-25 发布日期:2015-11-19
  • 作者简介:王学盛(1969-),男,副主任检验师。研究方向：实验检验的临床诊断应用。

Clinical significance of D-dimer and antithrombin detection in children with nephrotic syndrome

WANG Xuesheng   

  1. Testing Department，Zhuanghe Central Hospital，Zhuanghe 116400，China.
  • Online:2015-10-25 Published:2015-11-19

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摘要： 目的 检测肾病综合征儿童血浆D-二聚体及抗凝血酶的含量,为判断血栓形成提供依据。方法 39例肾病综合征患儿为观察组,同期选取40例健康体检儿童为对照组。两组均抽取清晨空腹静脉血1 mL,离心后取上清液检测血浆中D-二聚体及抗凝血酶含量。并对两组结果进行比较。结果 与对照组比较，观察组D-二聚体含量明显升高；抗凝血酶活性明显下降，两组比较差异有统计学意义(P＜0.05)。结论 检测肾病综合征儿童血浆D-二聚体及抗凝血酶的含量对于判断血栓的形成具有重要意义。

关键词: 肾病综合征, D-二聚体, 抗凝血酶, 血栓, 诊断, 儿童

Abstract: ObjectiveTo determine the concentration of D-dimer and antithrombin in children with nephrotic syndrome, and to provide evidence for the formation of thrombosis.MethodsTotally 39 children with nephrotic syndrome were observed, and 40 healthy children were selected as control group. In the two groups, 1 mL of blood was extracted in the early morning, and the D-dimer and antithrombin concentration in the plasma were detected by centrifugation. The results of the two groups were compared.ResultsThe concentration of D-dimer in the observation group was significantly higher than that in the control group, and the concentration of antithrombin was significantly lower than that in the control group,the difference being statistically significant(P＜0.05).ConclusionIt is important to determine the concentration of D-dimer and antithrombin in children with nephrotic syndrome in determining thrombosis.

Key words: nephrotic syndrome, D-dimer, antithrombin, thrombosis, diagnosis, children

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