ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (4): 280-282.doi: 10.3969/j.issn.1674-3865.2018.04.002

• 实验论著 • 上一篇    下一篇

归肺经中药提取物对人肺炎支原体的抑菌试验

岑凯莹,王海颖   

  1. 200120 上海,上海中医药大学中药学院2015级中药学专业研究生(岑凯莹);上海中医药大学中药教研室(王海颖)
  • 出版日期:2018-08-25 发布日期:2018-12-03
  • 通讯作者: 王海颖,E-mail:wanghaiying_7@hotmail.com
  • 作者简介:岑凯莹(1992-),女,上海中医药大学2015级硕士研究生在读。研究方向:中医药治疗小儿肺炎支原体肺炎
  • 基金资助:
    国家自然科学基金资助项目(81403345);上海市教委科研创新项目(14YZ059);研究生创新能力项目(B201724)

Bacteriostatic effect of Gui-Fei-Jing Chinese medicine extract on Mycoplasma pneumoniae

CEN Kaiying,WANG Haiying   

  1.  Shanghai University of Traditional Chinese Medicine,Shanghai 200120,China
  • Online:2018-08-25 Published:2018-12-03

摘要:
目的
观察鱼腥草、地龙、桑白皮组成的小复方,单味药以及药物两两配伍的水提物、醇提物体外抑制肺炎支原体的作用。
方法
进行肺炎支原体培养及药敏试验。采用微量肉汤稀释法(MIC法)测定各组对肺炎支原体的体外抑制作用。
结果
各组均具有抑制肺炎支原体的作用,小复方醇提物组MIC值显著低于鱼腥草水提组和醇提组、桑白皮水提组和醇提组、地龙+桑白皮水提组和醇提组、桑白皮+鱼腥草水提组和醇提组,差异有统计学意义(P<0.01)。
结论
各中药提取物均具有抑菌作用,配伍使用可增强抑菌作用。

关键词: 肺炎支原体, 鱼腥草, 地龙, 桑白皮/抑菌

Abstract:
Objective:
To observe the effect of the water extract or ethanol extract of Houttuynia (H. cordata), pberetima and Cortex Mori, whether in compound, or used alone, or used by combining either two of them, in inhibiting Mycoplasma pneumoniae in vitro.
Methods:
Mycoplasma pneumoniae was cultured and the drug sensitivity test was performed. MIC method was used to determine the in vitro inhibitory effect of each group of combination on Mycoplasma pneumoniae.
Results:
All groups had inhibitory effect on Mycoplasma pneumoniae. Among them, the MIC value in the ethanol extract of compound group, which was significantly lower than that in the water extract and the ethanol extract of Houttuynia cordata,the water extract and the ethanol extract of Cortex Mori, the water extract and the ethanol extract of the combination group of pberetima and Cortex Mori,and the water extract and the ethanol extract of the combination group of Cortex Mori and Houttuynia cordata,the difference being statistically significant(P<0.01).
Conclusion:The Chinese medicine extract has bacteriostatic effect, and if used in combination, the effect will be enhanced.

Key words: Mycoplasma pneumoniae, Houttuynia cordata, Pberetima, Cortex Mori, Bacteriostatic