ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (1): 69-71.doi: 10.3969/j.issn.1674-3865.2019.01.019

• 临床研究 • 上一篇    下一篇

枸橼酸咖啡因应用于极早早产儿的临床疗效分析

肖景霞，张成云，安丽花   

  1. 450003 郑州，郑州市第一人民医院新生儿科
  • 出版日期:2019-02-25 发布日期:2019-07-11
  • 通讯作者: 张成云，E-mail：zzsyy2008@126.com
  • 作者简介:肖景霞（1985-），女，医学硕士，主治医师。研究方向：新生儿疾病的诊治

Clinical efficacy of caffeine citrate in the treatment of very early preterm infants

XIAO Jingxia，ZHANG Chengyun，AN Lihua   

  1. Zhengzhou First People's Hospital，Zhengzhou 450003，China
  • Online:2019-02-25 Published:2019-07-11

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摘要：
目的
观察枸橼酸咖啡因应用于极早早产儿的临床疗效。
方法
选择2013年5月至2018年4月郑州市第一人民医院收治的极早早产儿42例为研究对象，随机分为观察组和对照组各21例。对照组应用氨茶碱并联合使用呼吸机治疗，并定期监测氨茶碱血药浓度，使血药浓度维持在5～10 mg/L；观察组应用枸橼酸咖啡因并联合使用呼吸机进行治疗，观察比较两组患儿的临床疗效、治疗后再次插管次数、撤机后呼吸暂停发生次数、呼吸机通气时间及不良反应。
结果
治疗后观察组临床总有效率为90.4%（19/21），显著高于对照组61.9%（13/21），差异有统计学意义（P<0.05）。两组治疗拔管后再次插管次数、呼吸暂停发生次数、呼吸机通气时间比较，差异均有统计学意义（P<0.05），两组治疗后再次插管上机指标均较治疗前降低，差异均有统计学意义（P<0.05）；观察组治疗后临床疗效指标均优于对照组，差异均有统计学意义（P<0.05）。两组不良反应发生率比较差异无统计学意义（P>0.05）。
结论
枸橼酸咖啡因应用于极早早产儿临床疗效优于氨茶碱。

关键词: 极早早产儿, 枸橼酸咖啡因, 机械通气

Abstract:
Objective
To observe the clinical efficacy of caffeine citrate in very early preterm infants.
Methods
From May 2013 to April 2018, 42 cases of very early preterm infants admitted to Zhengzhou First People's Hospital were selected as the subjects, and they were randomly divided into 21 cases in the observation group and 21 cases in the control group. The control group was treated with aminophylline and a ventilator, and the blood concentration of aminophylline was regularly monitored, so that the blood concentration was maintained at 5 to 10 mg/L. The observation group was treated with caffeine citrate and a ventilator. Observe the clinical efficacy of the two groups, the number of reintubation after treatment, the number of apnea after withdrawal, the ventilation time and the adverse reactions.
Results
The total effective rate of the observation group after treatment was 90.4%(19/21), which was significantly higher than that of the control group(61.9%,13/21), and the difference was statistically significant(P<0.05). There was statistical difference between the two groups in the number of reintubation and the number of apnea after withdrawal, and the ventilation time(P<0.05). After treatment, the indicators of reintubation on the machine in both groups were lower than before treatment, and the difference was statistically significant(P<0.05). The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of ADR between the two groups(P<0.05).
Conclusion
Citrate coffee for an early clinical efficacy is better than that of aminophylline.

Key words: Very early preterm, Caffeine citrate, Mechanical ventilation