ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (2): 121-124.doi: 10.3969/j.issn.1674-3865.2019.02.008

• 临床论著 • 上一篇    下一篇

特发性性早熟患儿肝郁与性发育的相关性

郭丽华，王菊霞，艾斯   

  1. 350004 福建 福州，福建中医药大学附属人民医院儿科
  • 出版日期:2019-04-25 发布日期:2019-05-08
  • 通讯作者: 王菊霞，E-mail：fanwjx@163.com
  • 作者简介:郭丽华（1987-），女，医师。研究方向：小儿内分泌疾病的中医治疗
  • 基金资助:
    福建中医药大学2017年临床专项校管课题（XB2017023）

Relationship between liver depression and sexual development in children with idiopathic precocious puberty

GUO Lihua，WANG Juxia，AI Si   

  1. Department of Pediatrics，People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine， Fuzhou 350004，China
  • Online:2019-04-25 Published:2019-05-08

PDF (PC)

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摘要：
目的
探讨特发性性早熟患儿肝郁与性发育的相关性。
方法
选择2018年8月至12月福建中医药大学附属人民医院收治的特发性性早熟女童35例为研究对象，为观察组；选择同龄的健康女童31例作为对照组。参照《证素辨证学》对其进行四诊信息采集，得到肝郁证素积分和肝郁分级，测定两组女童性激素水平，分析肝郁证素积分与性激素水平的相关性；测定特发性性早熟患儿乳核直径、卵巢容积、子宫容积，分析特发性性早熟组女童肝郁证素积分、肝郁分级与乳核直径、卵巢容积、子宫容积的相关性。
结果
观察组女童的FSH、LH、雌二醇均高于对照组，睾酮低于对照组，差异均有统计学意义（P<0.05）；观察组的肝郁证素积分高于对照组，差异有统计学意义（P<0.05）。两组中肝郁证素积分与性激素水平（FSH、LH、雌二醇、睾酮）均无相关性，差异无统计学意义（P>0.05）。观察组女童肝郁证素积分与乳核直径、卵巢容积、子宫容积均呈正相关，差异有统计学意义（P<0.01）；肝郁分级越高，乳核直径、卵巢容积、子宫容积值越高，且三者在不同肝郁分级间的差异有统计学意义（P<0.01）。
结论
肝郁可能参与了特发性性早熟患儿性发育的提早发生。

关键词: 特发性性早熟, 肝郁, 性发育, 儿童

Abstract:
Objective
To study the relationship between liver depression and sexual development in children with idiopathic precocious puberty.
Methods
Totally 35 girls with idiopathic precocious puberty, who were admitted to People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine from August to December, 2018,were selected as the research subjects(observation group). Thirty-one healthy girls of the same age were selected as the control group. According to the "Syndrome Differentiation School", we collect the four diagnosis information to get the integral and grade of liver depression, and the sex hormone levels of the two groups were measured to analyze the correlation between the integral of liver depression and sex hormone levels. The breast diameter, ovarian volume and uterine volume were measured in children with idiopathic precocious puberty, so as to explore their correlation with the integral and grade of liver depression.
Results
The FSH, LH and estradiol of the girls in the observation group and higher than those in the control group, while testosterone was lower. The difference was statistically significant(P<0.05). The integral of liver depression in the observation group was higher than that in the control group(P<0.05). There was no correlation between the integral of liver depression and the levels of sex hormones(FSH,LH,estradiol,testosterone), and there was no significant difference between the two groups(P>0.05). In the observation group, the integral of liver depression was positively correlated with breast diameter, ovarian volume and uterine volume, and the difference was statistically significant(P<0.01). The higher grade the liver depression, the higher the breast diameter, ovary volume and uterine volume, there were statistical differences among different liver depression grades(P<0.01).
Conclusion
Liver depression may be involved in the early occurrence of sexual development in children with idiopathic precocious puberty.

Key words: Idiopathic precocious puberty, Liver depression, Sexual development, Children