ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (3): 251-253.doi: 10.3969/j.issn.1674-3865.2019.03.020

• 临床研究 • 上一篇    下一篇

孤独症儿童血清中脑源性神经营养因子和S100B蛋白的检测及意义

马菲，任亮，陈素环   

  1. 462002 河南 漯河，漯河市源汇区妇幼保健院儿科（马菲）；462002 河南 漯河，漯河医学高等专科学校药学系（任亮）；462001 河南 漯河，漯河市第六人民医院儿童康复科（陈素环）
  • 出版日期:2019-06-25 发布日期:2019-07-04
  • 通讯作者: 马菲，E-mail：15839551648@163.com
  • 作者简介:马菲（1972-），女，副主任医师。研究方向：新生儿科学及康复儿科学

Detection and significance of serum BDNF and S100B protein levels in autistic children

MA Fei，REN Liang，CHEN Suhuan   

  1. Department of Paediatrics, Yuanhui District Maternal and Child Health Hospital of Luohe City,Luohe 462002，China
  • Online:2019-06-25 Published:2019-07-04

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摘要： 目的
检测孤独症儿童血清中脑源性神经营养因子（BDNF）和S100B蛋白的水平，探索BDNF和S100B蛋白及与儿童孤独症的关系。
方法
选择2016年3月至2017年9月在漯河市残疾人康复中心参与训练的孤独症患儿35例为研究对象，作为观察组，其中轻度孤独症24例，重度孤独症11例。同期选择健康儿童40例作为对照组。采用酶联免疫吸附法检测血清中BDNF和S100B蛋白的水平。
结果
观察组血清中BNDF水平显著高于对照组，差异有统计学意义（P＜0.05）。两组血清中S100B蛋白水平比较差异无统计学意义（P＞0.05）。轻度孤独症组血清中BDNF高于对照组，差异有统计学意义（P<0.05）；重度孤独症组与对照组比较差异无统计学意义（P>0.05）；轻、重度孤独症组之间比较差异无统计学意义（P>0.05）。
结论
孤独症儿童血清中BDNF显著升高，但S100B蛋白水升高不明显，说明BDNF与孤独症的发生、发展可能具有相关性，但S100B蛋白与孤独症的关系尚不十分明确。

关键词: 孤独症, 血清, 脑源性神经营养因子, S100B蛋白, 儿童

Abstract: Objective
To detect the levels of BDNF and S100B protein in serum of autistic children, and to explore the relationship of BDNF and S100B with autism in children.
Methods
Totally 35 autistic children who participated in training in Luohe Disabled Rehabilitation Center from March 2016 to September 2017 were selected as the study group, including 24 children with mild autism and 11 children with severe autism. Also, 40 healthy children were selected as the control group. ELISA was used to detect the levels of BDNF and S100B protein in serum.
Results
The serum BNDF level in the study group was significantly higher than that in the control group(P<0.05). There was no significant difference in serum S100B protein level between the two groups(P>0.05). The level of serum BDNF in mild autism group was higher than that in control group(P<0.05), but there was no significant difference between severe autism group and control group(P>0.05),and there was no significant difference between mild and severe autism group, either(P>0.05).
ConclusionThe level of serum BDNF in autistic children is significantly increased, but the level of S100B protein has no significant increase. These results suggest that BDNF may be related to the occurrence and development of autism, but the relationship between S100B protein and autism is not very clear.

Key words: Autism, Serum, BDNF, S100B, Children