ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (4): 322-326.doi: 10.3969/j.issn.1674-3865.2019.04.013

• 临床研究 • 上一篇    下一篇

基于中医传承辅助系统对中药膏方治疗小儿癫痫用药规律研究

焦阳,车雯锦,张葆青   

  1. 250014 济南,山东中医药大学第一临床医学院2017级中医儿科学专业研究生(焦阳,车雯锦);山东中医药大学附属医院儿科(张葆青)
  • 出版日期:2019-08-25 发布日期:2019-09-18
  • 通讯作者: 张葆青,E-mail:baoqin09009@163.com
  • 作者简介:焦阳(1993-),女,山东中医药大学2017级硕士研究生在读。研究方向:小儿呼吸系统及神经系统疾病的诊治

Rule of using traditional Chinese medicine gel in the treatment of epilepsy in children based on traditional Chinese medicine inheritance assistant system

JIAO Yang,CHE Wenjin,ZHANG Baoqing   

  1. First Clinical College of Shandong University of Traditional Chinese Medicine, Jinan 250014,China
  • Online:2019-08-25 Published:2019-09-18

摘要:
目的
运用中医传承辅助系统,分析和总结中药膏方治疗小儿癫痫的组方用药经验及规律,为临床膏方治疗小儿癫痫提供借鉴。
方法
收集在山东中医药大学附属医院儿科门诊上吾师张葆青教授运用膏方治疗小儿癫痫的病例,将组方信息录入“中医传承辅助系统”,利用数据改进互信息法、复杂系统熵聚法、无监督熵层次聚类法等数据挖掘方法,分析治疗小儿癫痫的膏方组方用药规律。
结果
对筛选出的115首膏方进行统计分析,其中涉及中药112味,得出处方中药物使用频次、频率,常用药对,通过药物之间的关联规则挖掘出14个核心组合和7个潜在新方组合。
结论
目前膏方治疗小儿癫痫多选用补虚、化痰、理气、平肝之品,治疗以补肾为本,平肝为主,佐以健脾,多采取豁痰开窍、益肾宁神、健脾平肝熄风之法。

关键词: 癫痫, 中药膏方, 中医药传承辅助平台, 组方用药规律, 儿童

Abstract:
Objective
To analyze and summarize the experience and rule of using traditional Chinese medicine gel in the treatment of epilepsy in children by using traditional Chinese medicine inheritance assistant system, so as to provide reference for clinical treatment of epilepsy in children with the gel.
Methods
Collect the cases of pediatric epilepsy treated by Prof. Zhang Baoqing with medicinal gel in the Pediatric Outpatient Department of Affiliated Hospital of Shandong University of Traditional Chinese Medicine; input the information of the prescription into the "Traditional Chinese Medicine Inheritance Assistant System". The data mining methods were adopted, such as improved mutual information method, complex system entropy aggregation method and unsupervised entropy hierarchical clustering method, and the rule of the gel prescriptions in the treatment of pediatric epilepsy was analyzed.
Results
Statistical analysis was conducted in 115 selected gel prescriptions, including 112 kinds of traditional Chinese medicines. The number of times and frequency of drug use in prescriptions were obtained. Fourteen core combinations and seven potential new combinations were discovered through analyzing the association among drugs.
Conclusion
Nowadays, most of the gel prescriptions for treating epilepsy in children include medicines tonifying deficiency, resolving phlegm, regulating qi and calming liver. The treatment is based on tonifying kidney and calming liver, supplemented by invigorating spleen. The methods of eliminating phlegm and resuscitating Qi, invigorating kidney and tranquilizing liver and calming wind are adopted.

Key words: Epilepsy, Traditional Chinese medicine gel, Traditional Chinese medicine inheritance assistant platform, Prescription medication rule, Child