ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学

• 临床研究 • 上一篇    下一篇

血清C反应蛋白及总IgE水平与患儿哮喘急性发作严重程度的相关性

陈艳瑛，罗兰，隆彩霞   

  1. 410007 长沙，湖南省儿童医院急救中心
  • 出版日期:2019-11-01 发布日期:2019-11-08
  • 通讯作者: 陈艳瑛，E-mail：cyying008@163.com
  • 作者简介:陈艳瑛（1987-），女，医学硕士，医师。研究方向：儿童急危重症的临床救治

Correlation between the level of serum C-reactive protein as well as total IgE and the severity of acute asthma attack in children

CHEN Yanying，LUO Lan，LONG Caixia   

  1. Department of Hunan Children's Hospital Emergency Center, Changsha 410007,China
  • Online:2019-11-01 Published:2019-11-08

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摘要： 目的
探究哮喘急性发作患儿血清C反应蛋白(CRP)水平及总IgE水平与哮喘发病严重程度的相关性。
方法
选取2017年1月至2018年12月本院门、急诊及住院的支气管哮喘患儿102例为研究对象，根据哮喘严重程度分为轻度组34例，中度组39例，重度组29例。同期选取健康体检儿童30例作为对照组。测定各组血清CRP、总IgE水平及一秒用力呼气容积/用力肺活量（FEVl％）值，对血清CRP及总IgE水平与哮喘患儿病情严重程度的相关性进行分析。
结果
轻度组、中度组、重度组血清CRP水平分别为（7.36±1.98）、（9.02±2.05）、（11.37±2.14）mg/L，显著高于对照组（1.02±0.67）mg/L，差异有统计学意义（P<0.05）。轻度组、中度组、重度组总IgE水平分别为（269.37±65.38）、（347.15±72.02）、（429.41±69.71）IU/mL显著高于对照组（81.53±23.03）IU/mL，差异有统计学意义（P<0.05）。轻度组、中度组和重度组FEV1%水平分别为65.33%、51.36%、38.21%，均显著低于对照组83.00%，差异有统计学意义（P<0.05）。Pearson相关性分析显示，在急性哮喘发作的患儿中血清CRP水平和总IgE水平与FEVl％均呈负相关性（r=-0.527，-0.481，P<0.05）。
结论
在哮喘急性发作的患儿中，血清CRP水平以及总IgE水平与哮喘急性发作严重程度呈负相关性。对哮喘急性发作患儿的血清CRP和IgE水平进行检测，有助于早期及时判断哮喘急性发作的严重程度，对疾病的诊治具有十分重要的意义。

关键词: 哮喘, 急性发作, C反应蛋白, 免疫球蛋白E, 一秒用力呼气容积/用力肺活量, 儿童

Abstract:
Objective
To investigate the correlation between the level of serum CRP as well as total IgE and the severity of asthma in children with acute asthma attack.
Methods
A total of 102 cases of children with bronchial asthma who were admitted to emergency center of our hospital from January 2017 to December 2018 were selected as research subjects. According to the severity of asthma, they were divided into 34 cases in mild group, 39 cases in moderate group and 29 cases in severe group. During the same period, 30 healthy children were selected as the control group. Serum CRP, total IgE levels and forced expiratory volume/forced vital capacity (FEVl %) in each group were measured, and the correlation between serum CRP as well as total IgE levels and severity of asthma in children was analyzed.
Results
Serum CRP levels in the mild, moderate and severe groups were (7.36±1.98), (9.02±2.05) and (11.37±2.14) mg/L, respectively, significantly higher than those in the control group (1.02±0.67) mg/L, 〖JP2〗with statistically significant differences (P<0.05). The total IgE levels of the mild, moderate and severe groups were (269.37±65.38), (347.15±72.02) and (429.41±69.71) IU/mL, respectively, significantly higher than those of the control group (81.53±23.03), with statistically significant differences (P<0.05). The levels of FEV1% in the mild, moderate and severe groups were 65.33%, 51.36% and 38.21%, respectively, all of which were significantly lower than those in the control group(83.00%), with statistically significant differences (P<0.05). Pearson correlation analysis showed that serum CRP and total IgE levels were negatively correlated with FEVl % in children with acute asthma attacks (r=-0.527, -0.481, P<0.05).
Conclusion
Serum CRP and total IgE levels are negatively correlated with the severity of acute asthma attack in children with acute asthma attack. The detection of serum CRP and IgE levels in children with acute asthma attack is helpful to early and timely judge the severity of acute asthma attack, which is of great significance for the diagnosis and treatment of the disease.

Key words: Asthma, Acute asthma attack, CRP, IgE, FEVl%, Children