ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (5): 429-431.doi: 10.3969/j.issn.1674-3865.2019.05.016

• 临床研究 • 上一篇    下一篇

喜炎平注射液对轮状病毒性腹泻患儿肠黏膜屏障及心肌酶谱水平的影响

陈广源   

  1. 463900 河南 驻马店,河南省西平县人民医院儿科
  • 出版日期:2019-11-01 发布日期:2019-11-08
  • 作者简介:陈广源(1985-),女,主治医师。研究方向:儿童消化系统疾病的诊治,E-mail:tu33944212581@163.com

Effect of Xiyanping injection on intestinal mucosal barrier and myocardial enzyme spectrum level in children with rotavirus diarrhea

CHEN Guangyuan   

  1. Xiping County People's Hospital, Zhumadian 463900,China
  • Online:2019-11-01 Published:2019-11-08

摘要:
目的
探讨喜炎平注射液对轮状病毒性腹泻患儿肠黏膜屏障及心肌酶谱水平的影响。
方法
选择2018年3月至2019年3月我院收治的轮状病毒性腹泻患儿90例为研究对象,随机分为对照组和观察组各45例。对照组采用常规治疗,观察组在对照组基础上采用喜炎平注射液静脉滴注,比较两组患儿治疗效果、肠黏膜屏障功能指标及心肌酶谱水平。
结果
观察组临床总有效率为95.6%(43/45),显著高于对照组80.0%(36/45),差异有统计学意义(P<0.05)。治疗后观察组内毒素、二胺氧化酶、D-乳酸、磷酸肌酸激酶同工酶、磷酸肌酸激酶、天门冬氨酸氨基转移酶、乳酸脱氢酶均低于对照组,差异有统计学意义(P<0.05)。
结论
在轮状病毒性腹泻患儿中应用喜炎平注射液治疗效果显著,可有效调节肠黏膜屏障,改善心肌酶谱水平,利于患儿转归。

关键词: 轮状病毒性腹泻, 喜炎平注射液, 肠黏膜屏障, 心肌酶谱, 儿童

Abstract:
Objective
To investigate the effect of Xiyanping injection on intestinal mucosal barrier and myocardial enzyme spectrum level in children with rotavirus diarrhea.
Methods
Ninety children with rotavirus diarrhea admitted to our hospital from March 2018 to March 2019 were randomly divided into control group and observation group, 45 cases in each group. The control group was treated with routine treatment, while the observation group was treated with Xiyanping injection on the basis of the treatment for control group. The therapeutic effect, intestinal mucosal barrier function index and myocardial enzyme spectrum level were compared between the two groups.
Results
The clinical total effective rate of observation group was 95.6%(43/45), which was significantly higher that of control group(80.0%,36/45), the difference being significant(P<0.05). After treatment, compared with the control group, endotoxin(ET), diamine oxidase(DAO), D-lactic acid(D-LAC), phosphocreatine kinase isoenzyme(CK-MB), phosphocreatine kinase(CK), aspartate aminotransferase(AST) and lactate dehydrogenase(LDH) in the observation group decreased, and the difference was statistically significant(P<0.05).
Conclusion
Xiyanping injection is effective in treating rotavirus diarrhea in children.It can effectively regulate the intestinal mucosal barrier,improve the level of myocardial enzymes,and benefit the prognosis of children with rotavirus diarrhea.

Key words: Rotavirus diarrhea, Xiyanping injection, Intestinal mucosal barrier, Myocardial enzyme spectrum, Children