ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2020, Vol. 12 ›› Issue (5): 399-402.doi: 10.3969/j.issn.1674-3865.2020.05.009

• 临床研究 • 上一篇    下一篇

早期新生儿骨代谢指标相关性分析

宿军，张文剑，官小妹   

  1. 519020 广东 珠海，珠海市中西医结合医院（珠海市第二人民医院）新生儿科（宿军，官小妹），产科（张文剑）
  • 出版日期:2020-10-25 发布日期:2020-11-28
  • 通讯作者: 宿军，E-mail:306202113@qq.com
  • 作者简介:宿军（1971-），男，医学硕士，副主任医师。研究方向：新生儿骨代谢
  • 基金资助:
    珠海市科技计划医疗卫生项目（20181117E030039）

Correlation analysis of bone metabolism indexes in early neonates

  • Online:2020-10-25 Published:2020-11-28

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摘要： 目的 探讨早期新生儿骨代谢指标之间是否具有相关性，减少代谢性骨病的发生。
方法 选择2018年7月至2019年12月珠海市中西医结合医院新生儿科住院的早期新生儿121例为研究对象，进行骨形成指标：血清总碱性磷酸酶（ALP）、总Ⅰ型胶原氨基端延长肽/总Ⅰ型前胶原N端前肽（PINP），骨吸收指标：β胶原降解产物/βⅠ型胶原交联羧基端肽区(β-CTX)，骨营养指标:钙（Ca2+)、磷（P）、25-羟胆骨化醇（25-（OH）D），骨代谢调节激素指标：甲状旁腺激素（PTH）、降钙素（CT）血清浓度检测，进行相关性分析。
结果 骨代谢指标PINP检测结果超出检测试剂最大范围，均>1 200.00 μg/L，该项指标未能进入相关性分析，ALP、β-CTX、Ca2+、P、25-（OH）D、PTH、CT的检测结果分别为（190.08±59.99）U/L、（0.85±0.33）μg/L、(2.41±0.17)mmol/L、(2.35±0.90)mmol/L、（12.76±4.98）μg/L、（32.02±27.20）ng/L、（5.35±5.05）ng/L。相关性分析发现ALP与PTH正相关；β-CTX与CT正相关，与P负相关；Ca2+与25-（OH）D正相关，P与PTH正相关，与CT负相关；PTH与CT负相关。
结论 新生儿骨代谢非常活跃，骨代谢指标之间存在复杂的相关关系，早期新生儿开始需要补充维生素D和摄入足够的钙、磷，增加骨量储备，减少代谢性骨病的发生。

关键词: 婴儿, 新生, 骨代谢标志物, 骨形成, 骨吸收, 骨营养

Abstract: Objective To explore the correlation of bone metabolism indexes in early neonates to reduce the occurrence of metabolic osteopathy.
Methods A total of 121 early newborns were enrolled for the study, who were hospitalized in the Department of Neonatology of Zhuhai Hospital of Itegrated Traditional Chinese and Western Medicine from July 2018 to December 2019. The analysis of the correlation of the bone metabolism indexes were done, by detecting the serum concentrations of indexes of bone formation(ALP, PINP), indexes of bone absorption(β- CTX), indexes of bone nutrition(Ca2+, P, 25-(OH) D), and indexes of bone metabolism regulating hormone(PTH, CT).
Results The results of PINP, which exceeded the maximum range of detection reagent, were all greater than1 200.00 μg/L,so it was not included in the analysis. The results of ALP, β-CTX, Ca2+, P, 25-(OH)D, PTH and CT were (190.08±59.99)U/L, (0.85±0.33)μg/L, (2.41±0.17)mmol/L, (2.35±0.90)mmol/L, (12.76±4.98)μg/L, (32.02±27.20)ng/L, and (5.35±5.05)ng/L, respectively. Correlation analysis showed that ALP was positively correlated with PTH; β-CTX was positively correlated with CT, while negatively correlated with P; Ca2+ was positively correlated with 25-(OH)D, and P was positively correlated with PTH, while negatively correlated with CT; PTH was negatively correlated with CT.
Conclusion Bone metabolism is very active in neonates, and there is a complex correlation among bone metabolism indexes. Early newborns need to be supplemented with vitamin D and take enough calcium and phosphorus in order to increase bone mass reserve and reduce the occurrence of metabolic osteopathy.

Key words: nfant,newborn, Bone metabolism markers, Bone formation, Bone absorption, Bone nutrition