ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2012, Vol. 4 ›› Issue (1): 19-22.doi: 10.3969/j.issn.1674-3865.2012.01.007

• 临床论著 • 上一篇    下一篇

不对称二甲基精氨酸与早产儿呼吸窘迫综合征的相关性分析

黄惠娟，陈玮琪，郑铠军，杨秀芳，陈敬国，叶春华   

  1. 528403 广东 中山，中山大学附属中山医院新生儿科（黄惠娟，郑铠军，杨秀芳，陈敬国，叶春华）；510080 广东 中山，中山大学附属第一医院新生儿科（陈玮琪）
  • 出版日期:2012-02-25 发布日期:2019-05-09
  • 作者简介:Neonatal respiratory distress syndrome/Asymmetric dimethylarginine/Cord blood/Infant/preterm

The relationship between serum asymmetric dimethylarginine and premature respiratory distress syndrome

HUANG Huijuan,CHEN Weiqi,ZHENG Kaijun,et al.   

  1. Neonatal Department,Zhongshan Hospital of Zhongshan University，Zhongshan 528403,China
  • Online:2012-02-25 Published:2019-05-09

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摘要：
目的:探讨不对称二甲基精氨酸（ADMA）与早产儿呼吸窘迫综合征（NRDS）的关系及脐血ADMA对预测NRDS的意义。
方法:以胎龄＜35周、体质量＜2 500 g的早产儿为研究对象，18例NRDS为实验组，其中分2级以上RDS组14例，1级RDS组4例；17例同期住院的早产儿为对照组。分别抽取脐带血，生后7、14 d桡动脉血各2 mL，用ELISA法进行ADMA检测。
结果:（1）ADMA变化:早产儿胎龄、出生体质量、分娩方式，母亲合并妊娠高血压综合征与脐血ADMA无明显相关关系；（2）ADMA与NRDS的关系：2级以上RDS组脐血中ADMA明显高于1级RDS组和对照组，差异有统计学意义（P<0.05）；生后7 d和14 d的ADMA水平各组比较差异无统计学意义（P＞0.05）；（3）2级以上RDS组脐血ADMA与机械通气时间、吸氧时间呈直线正相关关系（r=0.532，0.663，P<0.05）。
结论:脐血ADMA是独立于胎龄、出生体质量、分娩方式及母亲是否有妊娠高血压综合征的指标；脐血ADMA可能是2级以上NRDS的预测因子，脐血ADMA越高，机械通气和吸氧时间越长。

关键词: 不对称二甲基精氨酸/呼吸窘迫综合征, 脐带血/婴儿/早产

Abstract:
Objective:To investigate the relationship between ADMA and NRDS and whether cord blood concentration of ADMA is a reliable biochemical marker to predict respiratory distress syndrome in preterm infants.
Methods:Eighteen preterm infants with NRDS were included in experimental group and seventeen preterm infants whose gestation age was less then 35 weeks and birth weight was less than 2 500 g were in control group.Experimental group was divided into stage one group and stage two group.Draw 2 mL umbilical cord blood,and then draw 2 mL of radial artery blood respectively at 7 days and 14 days after birth.All the procedures were carried out strictly according to the supplied structure manuals in the ELISA kits.
Results:(1)There was no linear correlation between the level of cord plasma concentrations of ADMA and birth weight,gestational age,mode of delivery and mother with hypertensive disorder complicating pregnancy.(2)In stage two group the level of cord plasma concentration of ADMA was significantly higher than that of stage one and the control group(P<0.05).The levels at 7 days and 14 days were not significantly different between experimental group and control group.(3)The level of cord plasma concentration of ADMA in stage two group was significantly related to length of mechanical ventilation(r=0.532,P<0.05) and the length of oxygen(r=0.663,P<0.05).
Conclusions:The level of cord plasma concentration of ADMA is negatively correlated with birth weight,gestational age,mode of delivery and mother with hypertensive disorder complicating pregnancy.ADMA may be able to predict the occurrence of stage two NRDS.The higher the level of cord plasma concentrations of ADMA,the longer the time of mechanical ventilation and oxygen inhalation.