ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (5): 422-427.doi: 10.3969/j.issn.1674-3865.2018.05.016

• 临床论著 • 上一篇    下一篇

布拉酵母菌治疗小儿消化不良性腹泻有效性和安全性的Meta分析

李璇璇,汤有才,李元枭,殷雪翠   

  1. 450000 郑州,郑州大学2016级消化内科学专业研究生(李璇璇,李元枭,殷雪翠),儿科、科教科、河南省康复医学重点实验室(汤有才)
  • 出版日期:2018-10-25 发布日期:2018-12-03
  • 通讯作者: 汤有才,E-mail:tangyoucai@hotmail.com
  • 作者简介:李璇璇(1993-),女,郑州大学2016级硕士研究生在读。研究方向:代谢综合征和慢性肝损伤的诊治
  • 基金资助:
    国家自然科学基金项目(31471330);河南省科技厅国际合作项目(172102410014);河南省教育厅重点资助计划项目(18A320011)

Meta-analysis on the efficacy and safety of Saccharomyces boulardii in the treatment of pediatric dyspeptic diarrhea

LI Xuanxuan,TANG Youcai,LI Yuanxiao,YIN Xuecui   

  1. Department of  Gastroenterology, Zhengzhou University 5th Affiliated Hospital,Zhengzhou 450000,China
  • Online:2018-10-25 Published:2018-12-03

摘要:
目的
探讨布拉酵母菌治疗小儿消化不良性腹泻的有效性和安全性。
方法
计算机检索PubMed、Cochrane Central Register of Controlled Trial、CNKI全文数据库、VIP和WanFang Data等数据库,检索时限均从建库至2018年3月20日公开发表的布拉酵母菌治疗小儿消化不良性腹泻的随机对照试验。由2位研究人员独立进行文献筛选、数据提取和质量评价后,然后采用RevMen5.3软件进行Meta分析。
结果
共纳入有12个随机对照试验,1 198例患儿,Meta分析结果提示,患儿应用布拉酵母菌的有效率[OR=5.35,95%CI(3.55,8.09),P<0.000 01]明显高于对照组,呕吐缓解时间[MD=-1.07,95%CI(-1.62,-0.52),P=0.000 1],腹泻缓解时间[SMD=-2.57,95%CI(-4.22,-0.92),P=0.002],腹痛缓解时间[MD=-0.88,95%CI(-1.11,-0.64),P<0.000 01],大便次数恢复时间[MD=-1.37,95%CI(-1.69,-0.91),P<0.000 01],大便性状恢复正常时间[MD=-1.60,95%CI(-2.00,-1.20),P<0.000 01],脱水纠正时间[MD=-0.60,95%CI(-0.72,-0.48),P<0000 01]均短于对照组,但不明显缩短退热时间[MD=-050,95%CI(-1.40,0.40),P=0.28]。
结论
本研究结果提示布拉酵母菌在治疗小消化不良性腹泻相较于常规治疗有一定的优势,能缩短症状消失时间,但不能缩短退热时间。

关键词: 腹泻, 消化不良, 布拉酵母菌, Meta分析, 儿童

Abstract:
Objective
To explore the efficacy and safety of Saccharomyces boulardii in the treatment of pediatric dyspeptic diarrhea.
Methods
The databases such as PubMed, Cochrane Central Register of Controlled Trial, CNKI fulltext database, VIP, and WanFang Data were retrieved. The randomized controlled trials(RCT) on the treatment for pediatric dyspeptic diarrhea with Saccharomyces boulardii which were published publicly from the establishment of the database to March 20,2018 were collected. After two independent researchers conducted literature screening, data extraction and quality evaluation, RevMen 5.3 software was used for meta-analysis.
Results
A total of 12 randomized controlled trials and 1198 children were included. The meta-analysis showed that the effective rate of using Saccharomyces boulardii was significantly higher in children than in the control group[OR=5.35,95%CI(3.55,8.09),P<0.000 01], and the time for vomiting to relieve[MD=-1.07, 95%CI(-1.62,-0.52),P=0.000 1], diarrhea relief time[SMD=-2.57,95%CI(-4.22,-0.92),P=0.002],abdominal pain relief time[MD=-0.88,95%CI(-1.11,-0.64),P<0.000 01], stool recovery time[MD=-1.37,95%CI(-1.69,-0.91),P<0.000 01],time of stool trait returning to normal[MD=-1.60,95%CI(-2.00,-1.20),P<0.000 01],and dehydration correction time[MD=-0.60,95%CI(-0.72,-0.48),P<0.000 01] were shorter than the control group,but the antipyretic time[MD=-0.50,95%CI(-1.40,0.40),P=0.28] was not significantly shortened.
ConclusionThe results of this study suggest that Saccharomyces boulardii has certain advantages in the treatment of pediatric dyspeptic diarrhea compared with conventional treatment, which can shorten the time of disappearance of symptoms,but it can not shorten the time of fever.

Key words: Diarrhea, Dyspepsia, Saccharomyces boulardii, Meta-analysis, Child