ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (5): 431-433.doi: 10.3969/j.issn.1674-3865.2018.05.018

• 临床研究 • 上一篇    下一篇

Mur血型不合导致新生儿溶血病1例报告并文献复习

尹同进，王志军，胡雨生，雍其军   

  1. 224001 江苏 盐城，东南大学医学院附属盐城医院新生儿科（尹同进，胡雨生，雍其军）；835300 新疆 伊犁，新疆察布查尔锡伯自治县人民医院儿科（王志军）
  • 出版日期:2018-10-25 发布日期:2018-12-03
  • 通讯作者: 胡雨生，E-mail：478144964@qq.com
  • 作者简介:尹同进（1973-），男，主任医师。研究方向：新生儿重症监护
  • 基金资助:
    盐城市卫计委医学重点人才、青年人才项目（2016-4）

Hemolytic disease caused by Mur blood type incompatibility in one neonate and literatures review

YIN Tongjin，WANG Zhijun，HU Yusheng，YONG Qijun   

  1. Neonatal Department, Yancheng Hospital Affiliated to Southeast University Medical College，Yancheng 224001,China
  • Online:2018-10-25 Published:2018-12-03

PDF (PC)

123

摘要：
目的
总结1例Mur血型不合导致新生儿溶血病的临床特点及其治疗情况，并进行文献复习。
方法
对东南大学医学院附属盐城医院2012年5月收治的1例母子Mur血型不合导致的新生儿溶血病进行分析，对其临床症状、体征、实验室检查结果以及治疗进行分析总结。
结果
患儿为一5 d新生儿，生后2 d皮肤黄疸，入院前予以蓝光治疗2次，黄疸仍反复，体格检查可见轻度贫血貌，皮肤中重度黄染，血常规血红蛋白116 g/L，肝功能总胆红素371.2 μmol/L，直接胆红素30.6 μmol/L。溶血三项：直接抗人球蛋白试验阳性、游离抗体试验阴性、放散实验阳性。母亲血清学检出抗-Mur抗体，患儿Mur抗原阳性。
结论
母婴Mur血型不合可以导致严重的溶血，对排除ABO、Rh血型不合的溶血病的患儿，应考虑Mur血型不合导致的溶血病可能。

关键词: 溶血病, 抗-Mur, 婴儿, 新生

Abstract:
Objective
To summarize the clinical features of a neonate with hemolytic disease caused by Mur blood type incompatibility and make literature review.
Methods
To summarize and analyze the clinical data and laboratory test results of a neonate who was admitted to the Yancheng Hospital Affiliated to Southeast University Medical College with hemolytic disease caused by Mur blood type incompatibility.
Results
A 5-day old neonate had skin jaundice at 2 days after birth. After two times of treatment with blue light before admission to the hospital, the jaundice still existed. The physical examination showed appearance of mild anemia and moderate to severe jaundice of skin. The routine blood test showed that hemoglobin was 116 g/L, and live function test revealed that total bilirubin was 371.2 μmol/L and direct bilirubin was 30.6 μmol/L. The three-item detection of hemolysis showed that direct Coombs test was positive, free antibody test was negative and elution test was positive. Anti-Mur antibody was detected in mother's serum, and the Mur antigen of the neonate was positive.
ConclusionMur blood type incompatibility of mother and neonate can result in serious hemolysis. For the children with hemolysis without ABO or Rh blood type incompatibility, the Mur incompatibility should be considered as the cause of the disease.

Key words: Hemolytic disease, Anti-Mur, Infant,newborn