ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (6): 473-475.doi: 10.3969/j.issn.1674-3865.2018.06.004

• 专栏 • 上一篇    下一篇

毛细支气管炎患儿人鼻病毒感染的临床研究

孙頔，姜瑜，刘艳，高艳慧   

  1. 116035 辽宁 大连，大连市妇女儿童医疗中心儿内三病房
  • 出版日期:2018-12-25 发布日期:2019-03-25
  • 通讯作者: 孙頔，E-mail：sundidiyumen@163.com
  • 作者简介:孙頔(1978-)，女，医学硕士，副主任医师。研究方向：小儿呼吸系统疾病的诊治

Clinical study of human rhinovirus infection in infant with bronchiolitis

SUN Di, JIANG Yu, LIU Yan, GAO Yanhui   

  1. Dalian Municipal Women and Children's Medical Center, Dalian 116035, China
  • Online:2018-12-25 Published:2019-03-25

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摘要：
目的
分析毛细支气管炎患儿人鼻病毒(HRV)感染的临床特征，探讨过敏因素与HRV感染的关系。
方法
收集2015年1月至2016年12月大连市妇女儿童医疗中心收治的174例毛细支气管炎患儿的临床资料，将其分为HRV组29例，RSV组108例，比较两组的临床特征。
结果
HRV组29例患儿中，男女比例3.1∶1，平均年龄（9.0±3.0）个月；RSV组108例患儿中，男女比例1.5∶1，平均年龄（5.6±2.3）个月。HRV组年龄偏大(P=0.000)，热峰略高(P=0.003)。两组患儿在性别、胸部X线片影、并发症方面比较差异无统计学意义(P>0.05)。HRV组患儿合并湿疹比率明显升高(P=0.006)，嗜酸性粒细胞计数明显高于RSV组(P=0.006)，且家族性哮喘、父母一方罹患过敏性鼻炎多见(P=0.043、P=0.035)；父母双方(P=0.050)、二级亲属中过敏性鼻炎比例增高(P=0.054)。两组嗜碱性粒细胞计数比较差异无统计学意义(P>0.05)。
结论
HRV感染与RSV感染的毛细支气管炎临床特征相似，但HRV多发生于年龄稍大的婴幼儿，其热峰稍高于RSV患儿。个人特应性体质及家族哮喘、过敏性鼻炎可增加HRV感染毛细支气管炎的机会。

关键词: 毛细支气管炎, 人鼻病毒, 呼吸道合胞病毒, 过敏

Abstract:
Objective
To analyze the clinical features of human rhinovirus(HRV) infection in infants with bronchiolitis, and to explore the relationship between allergic factors and HRV infection.
Methods
The clinical data of 174 infants with bronchiolitis were collected, who were admitted to Dalian Municipal Women and Children's Medical Center from January 2015 to December 2016, and they were divided into HRV group and respiratory syncytial virus(RSV) group according to etiological test. The clinical characteristics of the two groups were retrospectively compared.
Results
In HRV group of 29 children, the ratio of male to female was 3.1∶1, and the average age was (9.0±3.0) months. In RSV group of 108 children, the ratio of male to female was 1.5∶1, and the average age was (5.6±2.3) months. The clinical features of infants with bronchiolitis in HRV group(n=29) were similar to those of RSV group(n=108), but HRV group was older than RSV group(P=0.000) and had a higher temperature(P=0.003). The incidence of eczema(P=0.006) was higher, and family history of asthma and allergic rhinitis in parents or secondary relatives in HRV group were more common than RSV group; the eosinophil counts(P=0.006) were higher, but there was no significant difference in basophil counts.
ConclusionThe clinical features of bronchiolitis with HRV and RSV infection are similar, but infants with HRV infection are older than those with RSV infection with higher temperature. Individual atopy, family history of asthma and allergic rhinitis increase the incidence of bronchiolitis with HRV infection.

Key words: Bronchiolitis, Human rhinovirus, Respiratory syncytial virus, Allergy