关键词: 黏膜皮肤淋巴结综合征, 肝功能损害, 静脉注射免疫球蛋白无反应, 儿童

Abstract:
Objective
To investigate the clinical characteristics, prognosis and related factors of liver dysfunction in Kawasaki disease in children．
Methods
A total of 105 Kawasaki children were included as the research subjects, who were treated in Dalian Children's Hospital from August 2017 to September 2018, and they were divided into two groups: normal liver function group(70 children) and liver dysfunction group(35 children).The two groups were compared in the following aspects: gender age, length of hospital stay, aspartate aminotransferase(AST)， alanine aminotransferase(ALT)， γ-glutamyl transpeptidase(GGT)，total bile acid，serum albumin，total bilirubin，C-reactive protein(CRP)，erythrocyte sedimentation rate, WBC count，platelet count，hemoglobin，and the incidence of IVIG no-response．
Results
The liver function became normal in 32 children of the liver dysfunction group, and the other 3 had normal liver function at the end of 2 months of follow-up. There was no difference in the length of hospital stay between the two groups(P>0.05). The incidence of IVIG no-response in normal liver function group was 5.7%(4/70), which was significantly lower than that in liver dysfunction group(20.0%,7/35)，the difference being statistical(P<0.05)．There was no statistical difference in serum albumin, hemoglobin, WBC count or erythrocyte sedimentation rate between the two groups(P>0.05). The AST, GGT, total bile acid, total bilirubin and CRP in liver dysfunction group were significantly higher than those in normal liver function group, while the platelet count was lower, and there was statistical difference(P<0.05).
Conclusion
Liver dysfunction is common in children with acute Kawasaki disease, and it is related to IVIG no-response. The liver dysfunction in Kawasaki disease should be paid attention to in order to ensure the proper treatment for the disease.

Key words: Kawasaki disease, Liver function damage, No response to IVIG, Child