ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (2): 170-172.doi: 10.3969/j.issn.1674-3865.2019.02.022

• 临床研究 • 上一篇    下一篇

氨溴索联合人免疫球蛋白治疗小儿重症肺炎对血清电解质及B型利钠肽和神经肽Y的影响

张永超，高罡   

  1. 471000 河南 洛阳，洛阳市妇女儿童医疗保健中心急诊科（张永超），PICU（高罡）
  • 出版日期:2019-04-25 发布日期:2019-05-08
  • 通讯作者: 张永超，E-mail:denty6569@163.com
  • 作者简介:张永超（1971-），男，副主任医师。研究方向：儿科重症的救治

Effects of ambroxol combined with human immunoglobulin on serum electrolytes, B-type natriuretic peptide and neuropeptide Y in the treatment of severe pneumonia in children

ZHANG Yongchao, GAO Gang   

  1. Department of Emergency, PICU, Luoyang Women and Children Health Care Center, Luoyang 471000, China
  • Online:2019-04-25 Published:2019-05-08

PDF (PC)

109

摘要：
目的
观察氨溴索联合人免疫球蛋白治疗小儿重症肺炎对血清电解质浓度及B型利钠肽（BNP）及神经肽Y（NPY）水平的影响。
方法
选择2017年4月至2018年8月洛阳市妇女儿童医疗保健中心收治的重症肺炎患儿86例为研究对象，随机分为观察组和对照组各43例。对照组患儿入院后接受肺部感染控制、呼吸支持、纠正酸中毒等基础治疗。观察组在对照组治疗基础上给予盐酸氨溴索葡萄糖注射液联合人免疫球蛋白治疗，治疗3～5 d。观察两组疗效、电解质指标及BNP、NPY水平。
结果
观察组治疗总有效率88.37%（38/43），显著高于对照组69.77%（30/43），差异有统计学意义（P<0.05）。治疗后两组血钾、血钠、血氯、血钙水平较治疗前均显著提高，差异有统计学意义（P<0.05）；治疗后观察组上述血清电解质指标均显著高于对照组，差异有统计学意义（P<0.05）。治疗后两组患儿BNP、NPY水平较治疗前均显著降低，差异有统计学意义（P<0.05）；治疗后观察组BNP、NPY水平均显著低于对照组，差异有统计学意义（P<0.05）。
结论
氨溴索联合人免疫球蛋白治疗重症肺炎患儿可改善重症肺炎症状，纠正电解质紊乱，效果显著。

关键词: 重症肺炎, 氨溴索, 人免疫球蛋白, 电解质, B型利钠肽, 神经肽Y, 儿童

Abstract:
Objective
To observe the effects of ambroxol combined with human immunoglobulin on serum electrolytes concentrations and levels of Btype natriuretic peptide (BNP) and neuropeptide Y (NPY) in children with severe pneumonia.
Methods
A total of 86 child patients with severe pneumonia admitted to Luoyang Women and Children Health Care Center were selected for the study and were randomly divided into observation group(n=43) and control group(n=43). Control group was given basic treatments after admission, including pulmonary infection control, respiratory support and acidosis correction, and observation group was given ambroxol hydrochloride injection combined with human immunoglobulin on the basis of treatment for control group, and they were treated for 35d. The efficacy, electrolytes indexes and levels of BNP and NPY were observed in the two groups.
Results
The total effective rate of treatment in observation group was significantly higher than that in control group［88.37%（38/43) vs 69.77%（30/43）,P<0.05］. After treatment, the levels of blood potassium, blood sodium, blood chlorine and serum calcium in the two groups were significantly increased compared with those before treatment(P<0.05). The above serum electrolytes indexes in observation group after treatment were higher than those in control group (P<0.05). After treatment, the levels of BNP and NPY in the two groups were significantly decreased compared with those before treatment (P<0.05). The levels of BNP and NPY in observation group after treatment were lower than those in control group (P<0.05).
Conclusion
Ambroxol combined with human immunoglobulin can improve the symptoms of severe pneumonia and correct electrolyte imbalance of children patients with severe pneumonia, and it has significant effects.

Key words: Severe pneumonia, Ambroxol, Human immunoglobulin, Electrolytes;B-type natriuretic peptide, Neuropeptide Y;Children