ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (2): 179-181.doi: 10.3969/j.issn.1674-3865.2019.02.025

• 临床研究 • 上一篇    下一篇

阿奇霉素联合孟鲁司特钠治疗小儿喘息性支气管炎的效果及对炎症水平的影响

屈昕   

  1. 461000 河南 许昌，许昌市中心医院儿科一病区
  • 出版日期:2019-04-25 发布日期:2019-05-08
  • 作者简介:屈昕(1984-)，女，主治医师。研究方向：小儿呼吸系统疾病的诊治，E-mail：qunxinhn@163.com

Effect of azithromycin combined with montelukast sodium on children with asthmatic bronchitis and its effect on inflammation level

QU Xin   

  1. Department of Pediatrics，Xuchang Central Hospital，Xuchang 461000，China
  • Online:2019-04-25 Published:2019-05-08

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摘要：
目的
探讨小儿喘息性支气管炎患者应用阿奇霉素联合孟鲁司特钠治疗的效果及对其炎症水平的影响。
方法选取2017年1月至2018年6月许昌市中心医院儿科收治的喘息性支气管炎患儿87例为研究对象，随机分为单药组43例和联合组44例。单药组予阿奇霉素静脉滴注，联合组加用孟鲁司特钠口服，疗程1个月。观察两组临床疗效；两组患儿咳嗽、体温、喘息及哮鸣音消失时间和住院时间；炎症水平：检测外周血白细胞介素-10(IL-10)、IL-12、人嗜酸性粒细胞阳离子蛋白(ECP)和白三烯E4(LTE4)水平。
结果联合组临床总有效率为93.18%(41/44)，显著高于单药组76.74%(33/43)，差异有统计学意义(P<0.05)。联合组患儿住院时间，退热时间，咳嗽、哮鸣音及喘息消失时间均短于单药组，差异有统计学意义(P<0.05)。联合组治疗1个月后IL-10、ECP及LTE4水平低于单药组，IL-12水平高于单药组，差异有统计学意义(P<0.05)。
结论阿奇霉素联合孟鲁司特钠应用于小儿喘息性支气管炎患者，可迅速改善其症状、体征及炎症状态，效果显著。

关键词: 喘息性支气管炎, 阿奇霉素, 孟鲁司特钠, 儿童

Abstract:
Objective
To investigate the effect of azithromycin combined with montelukast sodium on children with asthmatic bronchitis and its effect on inflammation level.
Methods
Eighty-seven children with asthmatic bronchitis were divided into two groups by random number table method; 43 patients in the single-agent group were given intravenous infusion of azithromycin, and 44 patients in the combination group was treated with montelukast sodium orally in addition to azithromycin. The treatment lasted for one month as a course. Observe the clinical effects in the two groups, including the relief time of cough, fever, wheezing and wheezing rales as well as the length of hospital stay; for inflammation level, detect the level of IL-10, IL-12,ECP and LTE4 in the peripheral blood.
Results
The total effective rate of combination group was 93.18%(41/44),significantly  higher than that of the single-agent group（76.74%,33/43),and the difference was statistically significant (P<0.05). The relief time of fever, cough, wheezing and wheezing rales as well as the length of hospital stay was shorter in the combination group than in the single-agent group (P<0.05). After one month of treatment, the level of IL-10, ECP and LTE4 was lower in the combination group than in the single-agent group, while the level of IL-12 was higher(P<0.05).
Conclusion
Azithromycin combined with montelukast sodium in children with asthmatic bronchitis can rapidly improve the symptoms, signs and inflammation, and the effect is remarkable.

Key words: Asthmatic bronchitis, Azithromycin, Montelukast sodium, Children