ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (4): 321-323.doi: 10.3969/j.issn.1674-3865.2017.04.015

• 临床研究 • 上一篇    下一篇

普米克令舒、万托林联合甲强龙治疗小儿毛细支气管炎疗效观察

刘亚涛   

  1. 451200 河南 巩义,巩义市人民医院儿科监护室
  • 出版日期:2017-08-25 发布日期:2017-12-08
  • 作者简介:刘亚涛(1983-),女,主治医师。研究方向:小儿呼吸系统疾病的诊治,E-mail:nkfdhgjk@sina.com

Observation on the effect of pulmicort respulas and ventolin combined with methylprednisolone in the treatment of children with bronchiolitis

LIU Yatao   

  1. Gongyi People's Hospital,Gongyi 451200,China
  • Online:2017-08-25 Published:2017-12-08

摘要:
目的
观察普米克令舒、万托林联合甲强龙治疗小儿毛细支气管炎的临床疗效。
方法
选取2013年10月至2016年10月巩义市人民医院儿科收治的毛细支气管炎患儿118例为研究对象,随机分为观察组与对照组各59例。两组患儿入院后均给予吸氧、镇咳、抗病毒等常规治疗,合并细菌感染者给予抗生素治疗。对照组患儿在此基础上给予吸入用布地奈德混悬液(普米克令舒)1 mg与硫酸沙丁胺醇吸入气雾剂(万托林)0.5 mL溶于2 mL生理盐水中,通过氧气驱动给予雾化吸入进行治疗,吸入时间为10 min左右,间隔时间为8 h一次,连续治疗1周。观察组患儿在对照组基础上给予甲强龙注射液静脉滴注,每次1~2 mg/kg,每日2次,3 d为1个疗程。观察两组疗效及患儿咳嗽、喘憋、哮鸣音及肺部啰音消失时间,检测单核细胞趋化蛋白4(MCP-4)浓度,随访观察用药不良反应。
结果
治疗后观察组总有效率为98.3%(58/59),显著高于对照组86.4%(51/59),差异有统计学意义(P<0.05);观察组患儿在咳嗽、喘憋、哮鸣音以及肺部啰音症状消失时间均少于对照组,差异有统计学意义(P<0.05)。治疗后两组患儿较治疗前均有所降低,观察组患儿治疗后血清MCP-4浓度显著低于对照组,差异有统计学意义(P<0.05)。对照组患儿治疗期间出现1例声音嘶哑症状,观察组患儿治疗期间无一例出现用药不良反应,差异无统计学意义(P>0.05)。
结论
普米克令舒、万托林治疗小儿毛细支气管炎的基础上辅以甲强龙治疗,效果显著,缩短症状缓解时间,是目前较为安全且可靠的治疗方案,值得推广。

 

关键词: 毛细支气管炎, 普米克令舒, 万托林, 甲强龙, 疗效, 儿童

Abstract:
Objective
To observe the clinical effect of pulmicort respulas and ventolin combined with methylprednisolone in the treatment of children with bronchiolitis.
Methods
A total of 118 children with bronchiolitis were included in the study, who were treated in the Pediatric Department of Gongyi People's Hospital from Oct. 2013 to Oct. 2016. They were randomly divided into two groups:59 in observation group and 59 in control group. After admission to the hospital, they were given oxygen inhalation, antitussive and antiviral treatment, and those with viral infection were given antibiotic. In addition, the children in control group received budesonide suspension(plumicort respulas)(1 mg) and salbutamol sulfate inhalation aerosol(ventolin)(0.5 mL), which was mixed with normal saline(2 mL). Then it was inhaled by oxygen-driven method for about 10 minutes, once every eight hours, for continuously one week. The children in the observation group received the same treatment; besides, methylprednisolone injection was given through venous dripping,1~2 mg/kg, twice a day, for 3 day as a course. Observe the effect of the two groups, as well as the time for cough, asthma, wheezing and pulmonary rales to be relieved, determine the concentration of MCP-4 and follow up the incidence of adverse effects.
Results
The total effective rate in observation group was 98.3%(58/59),significantly higher than that in control group 86.4%(51/59), and the difference was statistically significant(P<0.05). The time for cough, asthma, wheezing and pulmonary rales to be relieved in the observation group was short than that in control group, and there was statistical difference(P<0.05). Concentration of MCP-4 decreased in both groups after treatment, which was even lower in the observation group(P<0.05). There was one case of hoarseness in the control group, while there was no adverse effect in the observation group, there being no statistical difference(P>0.05).
Conclusion
Pulmicort respulas and ventolin combined with methylprednisolone has significant effect in the treatment of children with bronchiolitis, and can shorten the time of relieving symptoms, which is currently safe and reliable, and worth promotion.

Key words: Bronchiolitis, Pulmicort respulas, Ventolin, Methylprednisolone, Effect, Child