ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (4): 324-326.doi: 10.3969/j.issn.1674-3865.2017.04.016

• 临床研究 • 上一篇    下一篇

凝血酶原时间和C反应蛋白联合检测在早期儿童脓毒症中的应用

罗兰，姚震亚，朱德胜   

  1. 410007 长沙，湖南省儿童医院急救中心
  • 出版日期:2017-08-25 发布日期:2017-12-08
  • 通讯作者: 罗兰，E-mail:335129775@qq.com
  • 作者简介:罗兰（1983-），女，医学硕士，主治医师。研究方向：儿科重症急诊医学

Determination of prothrombin time and C-reactive protein in early childhood bacterial sepsis

LUO Lan，YAO Zhenya，ZHU Desheng   

  1. Hunan Children's Hospital，Changsha 410007，China
  • Online:2017-08-25 Published:2017-12-08

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125

摘要：
目的
探讨凝血酶原时间和C反应蛋白联合检测对早期儿童脓毒症的诊断价值。
方法
2015年3月至2016年5月湖南省儿童医院急诊综合内科收治的脓毒症患儿30例，为观察组。同期选取普通发热患儿30例为对照组。分别检测和记录两组患儿发病24 h内外周静脉血的凝血酶原时间和C反应蛋白浓度，并对早期脓毒症的诊断准确度进行比较。
结果
观察组凝血酶原时间和C反应蛋白高于对照组，差异有统计学意义（P<0.05）。凝血酶原时间和C反应蛋白联合检测较单独检测两种指标中任一指标的特异性明显增高，假阳性降低，灵敏性亦有所降低。
结论
凝血酶原时间和C反应蛋白联合检测可以提高早期儿童脓毒症诊断的特异性，降低诊断的假阳性，有助于用于临床中对该病的早期诊断。

关键词: 脓毒症, 凝血酶原时间, C反应蛋白, 诊断, 儿童

Abstract:
Objective
To investigate the diagnostic value of determination of prothrombin time(PT) and C-reactive protein(CRP) in early childhood bacterial sepsis.
Methods
From March 2015 to May 2016, 30 children with bacterial sepsis and 30 children with common fever were treated in Hunan Children's Hospital, and they were assigned to study group and control group respectively. The prothrombin time and C-reactive protein(CRP) concentration in peripheral blood of the two groups were detected and recorded 24 hours after onset, and the accuracy of diagnosis was compared.
Results
The prothrombin time and C-reactive protein in the study group were significantly higher than those in the control group(P<0.05). The combined determination of prothrombin time and C-reactive protein was more specific than either of the two indexes. The false-positive rate and specificity were decreased.
Conclusion
The combined detection of prothrombin time and C-reactive protein can improve the diagnosis specificity of early bacterial septicemia in children and reduce the false positive rate of diagnosis. It is helpful in the early diagnosis of the disease.

Key words: Sepsis, Prothrombin time, C-reactive protein, Diagnosis, Children