ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (5): 372-374.doi: 10.3969/j.issn.1674-3865.2017.05.002

• 实验论著 • 上一篇    下一篇

肾综颗粒改善原发性肾病综合征患儿微炎症的临床疗效观察

孙响波，于妮娜，潘月丽   

  1. 266000 山东 青岛，青岛市海慈医疗集团（青岛市中医医院）肾病科（孙响波，于妮娜）|250011 济南，山东中医药大学附属医院儿科（潘月丽）
  • 出版日期:2017-10-25 发布日期:2017-12-18
  • 通讯作者: 孙响波，E-mail：sunxiangbo1982@163.com
  • 作者简介:孙响波（1982-），男，医学博士，主治医师。研究方向：中医药治疗肾病的临床与实验研究
  • 基金资助:
    山东省自然科学基金项目（2012ZRB14098）

Clinical effect of Shenzong granule on improving micro-inflammation of children with primary nephrotic syndrome

SUN Xiangbo，YU Nina，PAN Yueli   

  1. Qingdao Haici Medical Group，Qingdao 266000， China
  • Online:2017-10-25 Published:2017-12-18

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116

摘要：
目的
观察肾综颗粒对原发性肾病综合征（PNS）患儿临床疗效及对微炎症的影响。
方法
选择2012年3月至2014年3月山东中医药大学附属医院儿科收治的首诊PNS患儿40例为研究对象，随机分为观察组和对照组各20例。对照组常规对症治疗，并给予泼尼松2 mg/(kg·d)，尿蛋白转阴后至少巩固2周开始减量，改为隔日2 mg/kg，继用4周后每2~4周减量2.5 mg直至停药。观察组在对照组治疗基础上加用肾综颗粒治疗，2个月为1个疗程。观察临床疗效及24 h尿蛋白定量，血清白蛋白、总胆固醇、超敏C反蛋白水平。
结果
观察组总有效率为85%（17/20），与对照组75%（15/20）比较差异无统计学意义（P>0.05）。两组患儿治疗后血清白蛋白水平显著高于治疗前，超敏C反应蛋白、24 h尿蛋白定量、血清总胆固醇水平显著低于治疗前，差异有统计学意义（P<0.05）。观察组治疗后血清白蛋白水平显著高于对照组，超敏C反应蛋白、24 h尿蛋白定量、血清总胆固醇水平显著低于对照组，差异有统计学意义（P<0.05）。
结论
激素加肾综颗粒治疗PNS能明显下调PNS患儿血脂和超敏C反应蛋白水平，对PNS患儿“微炎症”状态有明显改善作用。

关键词: 原发性肾病综合征, 中药, 微炎症, 儿童

Abstract:
Objective
To observe the clinical effect of Shenzong granule on children with primary nephrotic syndrome and its influence on micro-inflammation.
Methods
A total of 40 PNS children were include in the research, who were treated in the Affiliated Hospital of Shandong TCM University from March 2012 to March 2014, and they were randomly divided into two groups ,20 cases in the observation group and 20 in the control group. Both groups were treated with conventional symptomatic treatment, and prednisone at 2 mg/(kg·d) was given, which was used for 2 weeks after the urine protein turned negative, and then it was given every other day at the same dose for continuously 4 weeks; after that, a dose of 2.5 mg was reduced every 2 to 4 weeks until it was stopped. On this basis, the observation group was also given Shenzong granule, two months as a course. Observe the clinical effect and 24h content of urine protein, and the level of serum albumin, total cholesterol and hypersensitive C-reactive protein.
Results
The total effective rate of observation group was 85%(17/20), which was not statistically different from that of control group(75%,15/20)(P>0.05). Compared with before treatment, the serum albumin level in both groups was significantly higher, while the level of hypersensitive C-reactive protein, 24h urine protein and total cholesterol was significantly lower after treatment, the difference being statistical(P<0.05). After treatment, the serum albumin level was significantly higher than that of control group, while the level of hypersensitive C-reactive protein, 24h urine protein and total cholesterol was significantly lower, and there was statistical difference(P<0.05).
Conclusion
The treatment with hormone and Shenzong granule for children with PNS can significantly down-regulate the level of serum lipid and hypersensitive C-reactive protein, which is effective in improving the micro-inflammation in PNS children.

Key words: Primary nephrotic syndrome, Traditional Chinese medicine, Micro-inflammation, Child