ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (5): 375-378.doi: 10.3969/j.issn.1674-3865.2017.05.003

• 实验论著 • 上一篇    下一篇

小儿紫癜疹消颗粒对过敏性紫癜患儿临床疗效及对白细胞介素4、6水平的影响

朱浩宇，钱美加，冯晓纯   

  1. 130021长春，吉林省中医院儿童诊疗中心（朱浩宇，冯晓纯）|130000长春，长春中医药大学2015级中医儿科专业研究生（钱美加）
  • 出版日期:2017-10-25 发布日期:2017-12-18
  • 通讯作者: 冯晓纯，E-mail：doctorzhuhaoyu@163.com
  • 作者简介:朱浩宇(1980-)，男，医学硕士，主治医师。研究方向：中医药防治小儿风湿免疫系统疾病
  • 基金资助:
    吉林省卫生计生自筹经费课题（2015ZF2C10）|吉林省中医药管理局紫癜解毒凉血重点研究室

Clinical effect of Pediatric Purpura Rash Elimination Particles on children with Henoch Schonlein purpura and its influence on the levels of IL-4 and IL-6

ZHU Haoyu, QIAN Meijia,FENG Xiaochun   

  1. Children's Diagnosis and Treatment Center of Jilin Provincial Hospital of TCM, Changchun 130021,China
  • Online:2017-10-25 Published:2017-12-18

PDF (PC)

107

摘要：
目的
观察紫癜疹消颗粒对过敏性紫癜患儿的临床疗效及对白细胞介素4、6水平的影响。
方法
选取2016年1月至12月在长春中医药大学附属医院儿科门诊和住院部就诊的过敏性紫癜患儿60例，随机分为观察组和对照组各30例。对照组给予清热解毒中药喜炎平注射液、维生素C、10%葡萄糖酸钙注射液等药物静脉滴注对症支持治疗。观察组在对照组治疗基础上口服小儿紫癜疹消颗粒，疗程共7 d。采用酶联免疫吸附法检测白细胞介素4和白细胞介素6。治疗后观察两组临床疗效及白细胞介素4、6变化情况。
结果
观察组总有效率为93.3%（28/30），显著高于对照组73.3%（22/30），差异有统计学意义(P<0.05)。两组患儿治疗后血清白细胞介素4及白细胞介素6水平均低于治疗前，差异有统计学意义（P<0.05）|观察组治疗后血清白细胞介素4及白细胞介素6水平均显著低于对照组，差异有统计学意义（P<0.05）。
结论
小儿紫癜疹消颗粒治疗过敏性紫癜疗效显著，且可能调节白细胞介素4、6水平。

关键词: 过敏性紫癜, 紫癜疹消颗粒, 白细胞介素4, 白细胞介素6, 儿童

Abstract:
Objective
To observe the clinical effect of Pediatric Purpura Rash Elimination Particles on children with Henoch Schonlein purpura and its influence on the levels of IL-4 and IL-6.
Methods
A total of 60 children with Henoch Schonlein purpura were selected from Outpatient Department of Pediatrics and Inpatient Department of Changchun University of TCM Affiliated Hospital, who were treated from January 2016 to December. They were divided into observation group and control group with 30 cases in each group according to random number table method. The control group was given Xiyanping injection and vitamin C, 10% calcium gluconate injection for intravenous symptomatic treatment. On the basis of the treatment for the control group, Pediatric Purpura Rash Elimination Particles was used in the observation group, the course of treatment lasting for 7d. IL-4 and IL-6 were detected by enzyme linked immunosorbent assay(ELISA). After treatment, the clinical efficacy and the changes of IL-4 and IL-6 in the two groups were observed.
Results
The total effective rate of the observation group was 93.3%(28/30), which was significantly higher than that of the control group 73.3%(22/30), and the difference was statistically significant(P<0.05). The average serum level of IL-4 and IL-6 was lower after treatment in the two groups than before treatment, the difference being statistically significant(P<0.05); in the observation group after treatment, serum level of IL-4 and IL-6 was significantly lower than the control group, the difference being statistically significant(P<0.05).
Conclusion
The effect of Pediatric Purpura Rash Elimination Particles is remarkable, which may adjust IL-4 and IL-6 levels.

Key words: Henoch Schonlein purpura, Pediatric Purpura Rash Elimination Particles, IL-4;IL-6, Child