ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (5): 389-391.doi: 10.3969/j.issn.1674-3865.2017.05.007

• 临床研究 • 上一篇    下一篇

伏立康唑治疗儿童白血病侵袭性肺部真菌感染疗效观察

张本山,吴攀,何姗,宋娜   

  1. 410007 长沙,湖南省儿童医院血液内科
  • 出版日期:2017-10-25 发布日期:2017-12-18
  • 通讯作者: 吴攀,E-mail:571653901@qq.com
  • 作者简介:张本山(1977-),男,医学硕士,副主任医师。研究方向:小儿血液系统疾病的诊治

Efficacy of voriconazole in the treatment of invasive pulmonary fungal infection in children with leukernia

ZHANG Benshan,WU Pan,HE Shan,SONG Na   

  1. Department of Hematology, Hunan Children's Hospital, Changsha 410007, China
  • Online:2017-10-25 Published:2017-12-18

摘要:
目的
观察伏立康唑治疗儿童白血病侵袭性肺部真菌感染的疗效和安全性。
方法
选取2010年1月至2016年1月湖南省儿童医院血液内科收治的白血病侵袭性肺部真菌感染患儿43例为研究对象,随机分为观察组22例和对照组21例。对照组行两性霉素B治疗,观察组行伏立康唑治疗,比较两组临床疗效、细菌清除率及用药期间的不良反应(肝脏损害、低钾血症、肾脏损害、静脉炎及消化道反应)。
结果
观察组治疗总有效率及细菌清除率分别为81.8%(18/22)、86.4%(19/22),均显著高于对照组52.4%(11/21)、57.1%(12/21),差异有统计学意义(P<0.05)。观察组不良反应发生率为13.6%(3/22),显著低于对照组42.9%(9/21),差异有统计学意义(P<0.05)。
结论
儿童白血病侵袭性肺部真菌感染采用伏立康唑进行治疗,具有获得良好的临床效果。

关键词: 白血病, 侵袭性肺部真菌感染, 伏立康唑, 儿童

Abstract:
Objective
To observe the efficacy and safety of voriconazole in the treatment of invasive pulmonary fungal infection in children with leukemia.
Methods
Forty-three children with invasive pulmonary fungal infection were randomly divided into observation group(n=22) and control group(n=21).The control group was treated with amphotericin B and the observation group was treated with voriconazole. The clinical efficacy, bacterial clearance and adverse reactions (liver damage, hypokalemia, renal damage, phlebitis and gastrointestinal reactions) were compared between the two groups.
Results
The total effective rate and bacterial clearance rate of the observation group were 81.8%(18/22) and 86.4%(19/22) respectively, which were significantly higher than those of the control group [52.4%(11/22),57.1%(12/21)], the difference being statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 13.6%(3/22), which was significantly lower than that in the control group(42.9%, 9/21), the difference being statistically significant(P<0.05).
Conclusion
Voriconazole, as a drug for invasive pulmonary fungal infection in children, is safe and effective and deserves to be widely used clinically.

Key words: Leukemia, Invasive pulmonary fungal infection, Voriconazole, Children