ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (2): 172-174.doi: 10.3969/j.issn.1674-3865.2017.02.027

• 调查研究 • 上一篇    下一篇

200例儿童肺炎支原体感染的流行病学和耐药性分析

吴俊填，张佳彬，周曙明   

  1. 518116 广东 深圳，深圳市龙岗中心医院儿科
  • 出版日期:2017-04-25 发布日期:2017-12-18
  • 通讯作者: 吴俊填，E-mail：hxme2013@163.com
  • 作者简介:吴俊填(1978-)，男，医学硕士，主治医师。研究方向：小儿呼吸系统疾病的诊治

Analysis of epidemiology and drug resistance in 200 children with mycoplasma pneumonia

WU Juntian, ZHANG Jiabin, ZHOU Shuming   

  1. Department of Pediatirics，Shenzhen Longgang Central Hospital，Shenzhen 518116，China
  • Online:2017-04-25 Published:2017-12-18

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261

摘要：
目的：对200例儿童肺炎支原体(MP)感染的流行病学和耐药性进行分析，为临床治疗提供指导。
方法：2014年1月至12月深圳市龙岗中心医院儿科门诊收治呼吸道感染患儿652例。通过咽拭子进行MP培养，统计不同季节、不同年龄段、不同性别间MP感染情况及不同抗生素间耐药率。
结果：在对652例呼吸道感染患儿进行咽拭子标本培养中，MP培养结果阳性200例，总阳性率为30.67%。不同季节MP分离培养阳性率存在差异,冬季时MP分离培养阳性率最低(15.00%)，显著低于其他季节(P<0.05)，秋季最高，为38.50%。男性患儿MP感染阳性率为30.02%(124/413)，略低于女性患儿,31.80%(76/239)，差异无统计学意义(P>0.05)。不同年龄组MP感染阳性率比较差异有统计学意义(P<0.05)。0～1岁患儿MP感染阳性率显著高于>6～14岁患儿，差异有统计学意义(P<0.008 3)。其余各时间段两两比较差异无统计学意义(P>0.008 3)。药敏试验表明不同抗生素耐药率比较差异有统计学意义(P<0.05)。红霉素、罗红霉素耐药率均显著高于阿奇霉素，差异有统计学意义(P<0.005)。其他抗生素耐药率两两比较差异均无统计学意义(P>0.005)。
结论：呼吸道感染患儿中MP感染所占比例较高，并且与年龄有关，冬季少发，在临床治疗时需进行MP咽拭子培养和药敏检测以指导临床用药治疗。

关键词:  肺炎支原体, 流行病学, 耐药性, 儿童

Abstract:
Objective：To analyze the epidemiology and drug resistance in 200 children with mycoplasma pneumonia and to provide reference for clinical treatment.
Methods：Throat swabs were collected from 652 children with respiratory infection in out-patient department in our hospital. The swabs were cultured to detect MP. The MP infection was recorded according to seasons, ages and gender. The drug resistance to multiple antibiotics was detected.
Results：MP culture showed that the positive rate was 30.67%;the infection rates in different seasons had differences, and the infection rate was the lowest in winter(15.00%), which was significantly lower than that in other seasons(P<0.05),and it was the highest in fall(38.50%);the infection rate in male children was slightly lower than the female patients(30.02% vs 31.80%,P>0.05);the infection rates in different age groups were significantly different(P<0.05):0-1-year-old group was higher than the 6-14-year-old group(P<0.008 3). Susceptibility test showed that drug resistance rates were significantly different to different antibiotics(P<0.05).ERY and ROX resistance rates were significantly higher than AZI(P<0.05).
Conclusion：MP infection in children with respiratory tract infection has high proportion, which is age-related; it doesn't often occur in winter, and in the clinical treatment MP throat swab culture and drug sensitivity testing are required to guide the clinical administration.

Key words: Mycoplasma pneumoniae, Epidemiological, Drug resistance, Children