ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (2): 175-177.doi: 10.3969/j.issn.1674-3865.2017.02.028

• 调查研究 • 上一篇    下一篇

1 214例急性呼吸道感染住院患儿9种病原体检测分析

王敏华   

  1. 214200 江苏 宜兴，宜兴市中医医院儿科
  • 出版日期:2017-04-25 发布日期:2017-12-18
  • 作者简介:王敏华(1980-)，女,医学硕士，主治医师。研究方向：小儿呼吸系统疾病的诊治，E-mail：wangminhua353@163.com

Detection and analysis of 9 pathogens in hospitalized children with acute respiratory infection in 1 214 cases

WANG Minhua   

  1. Yixing Traditional Chinese Medicine Hospital, Yixing 214200,China
  • Online:2017-04-25 Published:2017-12-18

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摘要：
目的：分析急性呼吸道感染住院患儿病原体的特点，为临床早期病原学诊断和合理用药提供依据。
方法：2014年5月至2015年7月宜兴市中医医院儿科收治住院的急性呼吸道感染患儿1 214例，采用间接免疫荧光法检测患儿血清中9种常见病原体IgM抗体，并对上述病原谱、病原流行情况等进行资料汇总分析。
结果：1 214例急性呼吸道感染患儿中检出病原体IgM抗体阳性371例，阳性率30.5%，其中肺炎支原体阳性率最高，占总样本的16.8%，其次是乙型流感病毒(5.8%)和副流感病毒(2.7%)。205例患儿肺炎支原体混合其他1种或1种以上感染，占总混合感染的55.2%。肺炎支原体春夏季病毒检出率高于秋冬季，差异有统计学意义(P<0.008 3)。乙型流感病毒夏季病毒检出率高于秋季，差异有统计学意义(P<0.008 3)。1～3岁患儿肺炎支原体感染率均高于<1岁和>3岁患儿，差异有统计学意义(P<0.017)；1～3岁患儿乙型流感病毒感染率均高于<1岁和>3岁患儿，但差异无统计学意义(P>0.017)；不同年龄段副流感病毒感染率比较差异无统计学意义(P>0.05)。
结论：本院急性呼吸道感染住院患儿主要病原体是肺炎支原体、乙型流感病毒、副流感病毒；肺炎支原体合并其他病原体感染比较普遍；肺炎支原体和乙型流感病毒以夏季感染为主；1～3岁肺炎支原体感染率高。

关键词: 急性呼吸道感染, 呼吸道病原体, 混合感染, 儿童

Abstract:
Objective：To analyze the pathogen characteristics among hospitalized children with acute respiratory infections(ARI) and provide the basis for early etiology diagnosis and rational use of drugs.
Methods：Total1y 1 214 cases of hospitalized ARI children from May 2014 to July 2015 were included as research subjects. Indirect immunofluorescence assay(IFA) was applied to detect serum IgM antibodies of nine kinds of common pathogens, and the above-mentioned pathogen spectrum and prevalence state were analyzed.
Results：Among 1 214 cases of ARI children, positive rate of pathogen IgM antibody was 30.5% (371 cases). Positive rate of mycoplasma pneumoniae(MP) was the highest(16.8%), followed by influenza B virus(Flu B)(5.8%) and parainfluenza virus(PIV)(2.7%).A total of 205 cases of children had  MP infection mixed with another one kind or more than one kind of infection, accounting for 55.2% of total  mixed infections. There was statistical significance on infection rate of MP between different seasons (P＜0.008 3). The number of 1 to 3-year old children with pneumonia mycoplasma and hepatitis b virus infection was higher than that of children < 1 year old and > 3 years old(P<0.017). There was statistical significance on infection rate of Flu B between different seasons(P<0.008 3).The number of 1 to 3-year old children with flu viruses infection was higher than that of children < 1 year old and > 3 years old, but there was no statistically significant difference(P>0.017).
Conclusion：The major pathogens of hospitalized ARI children in our hospital are MP, Flu B and PIV; the mixed infection of MP with other pathogens is relatively common; MP and Flu B infections mainly occur  in summer; the infection rate of MP in children between 1 and 3 years old is high.

Key words: Acute respiratory infections, Pathogen, Mixed infection, Child