ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (3): 257-259.doi: 10.3969/j.issn.1674-3865.2019.03.022

• 临床研究 • 上一篇    下一篇

自拟中药退热方对2018年中山地区甲型流行性感冒患儿呼吸道黏膜免疫功能的影响

张琳，何德根，陈慧   

  1. 528400 广东 中山，广州中医药大学附属中山市中医院儿科
  • 出版日期:2019-06-25 发布日期:2019-07-04
  • 通讯作者: 张琳，E-mail：zengqingbo_521@163.com
  • 作者简介:张琳（1978-），女，医学硕士，副主任医师。研究方向:中医治疗小儿呼吸道疾病

Effect of self-prescribed Tuirefang on respiratory mucosal immunity of children infected with  influenza A in Zhongshan in 2018

ZHANG Lin，HE Degen，CHEN Hui   

  1. Zhongshan Chinese Medicine Hospital，Zhongshan 528400，China
  • Online:2019-06-25 Published:2019-07-04

PDF (PC)

95

摘要： 目的
观察自拟中药汤剂退热方对证属气分实热型的甲型流行性感冒患儿的退热效果及其对患儿唾液中分泌型免疫球蛋白A(sIgA)与血清白蛋白(ALB)比值的影响。
方法
选取2018年秋冬季甲型流行性感冒（气分实热型）患儿200例，随机分为观察组和对照组各100例。两组患儿均予以退热治疗，对照组予以奥司他韦口服，观察组予以中药退热方口服，治疗3 d后比较两组退热时间和治疗前后sIgA/ALB的变化情况。
结果
观察组退热时间为（1.85±0.26）d，短于对照组（2.50±0.30）d，差异有统计学意义（P<0.05）。两组治疗后sIgA/ALB均较治疗前升高，观察组升高较对照组明显，两组比较差异有统计学意义（P<0.05）。
结论
中药退热方较西药奥司他韦退热时间快，明显提升甲型流行性感冒患儿呼吸道黏膜免疫功能。

关键词: 甲型流行性感冒, 中药汤剂, 黏膜免疫, 唾液分泌型IgA, 儿童

Abstract: ZHANG Lin，HE Degen，CHEN Hui. Zhongshan Chinese Medicine Hospital，Zhongshan 528400，China
Objective
To observe the antipyretic effect and the change of sIgA/ALB in influenza A children with excess heat due to Qi deficiency treated by self-prescribed Tuirefang of Chinese medicine.
Methods
Totally 200 influenza A children with excess heat due to Qi deficiency in autumn-to-winter of 2018 were randomized into study group and control group, with 100 cases in each. Two groups were given antipyretic treatment. The study group was given Tuirefang, and the control group was given oseltamivir taken orally. Three days after treatment, the antipyretic effect and change of sIgA/ALB were compared between two groups．
Results
The antipyretic period of the study group was（1.85±0.26）days, and in the control group it was（2.50±0.30）days, the difference between two groups being significant(P<0.05)．The sIgA/ALB in two groups were higher after treatment, and the increase of study group was more obvious than that of control group, the difference being significant(P<0.05) between the two groups.
Conclusion
The antipyretic period of Tuirefang is shorter than that of oseltamivir, and it can increase the immune function of respiratory mucosal in influenza A children.

Key words: Influenza A, Chinese medicine decoction mucosal immunity, sIgA in saliva, Child