ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (4): 315-317.doi: 10.3969/j.issn.1674-3865.2019.04.011

• 临床研究 • 上一篇    下一篇

小婴儿巨细胞病毒性视网膜炎的临床分析

赵爱玲，丁大领，王江涛，李雪琴   

  1. 450018 郑州，郑州大学附属儿童医院，河南省儿童医院，郑州儿童医院小婴儿病区(赵爱玲，王江涛，李雪琴)；450052 郑州，郑州大学第一附属医院神经外科(丁大领)
  • 出版日期:2019-08-25 发布日期:2019-09-18
  • 通讯作者: 王江涛，E-mail:fccdingdl@zzu.edu.cn
  • 作者简介:赵爱玲(1982-)，女，医学硕士，主治医师。研究方向：小婴儿常见疾病的基础和临床研究
  • 基金资助:
    河南省自然科学基金项目(162300410311)

Clinical analysis of cytomegalovirus retinitis in infant

ZHAO Ailing, DING Daling, WANG Jiangtao, LI Xueqin   

  1.  Department of Infant Ward, Children's Hospital Affiliated to Zhengzhou University/Henan Children's Hospital/Zhengzhou Children's Hospital, Zhengzhou 450018, China
  • Online:2019-08-25 Published:2019-09-18

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摘要：
目的
探讨小婴儿巨细胞病毒性视网膜炎的临床特征、发病机制、诊断标准以及治疗策略。
方法
回顾性分析2015年8月至2018年6月收治的11例小婴儿巨细胞病毒性视网膜炎的临床病例资料，并复习相关文献，对该疾病的临床特征、治疗及预后等方面予以总结和分析。
结果
11例患儿中男4例，女7例；年龄1~8个月；9例以咳嗽或发热及2例以腹泻为首发症状入院；11例患儿血清CMV-DNA及11例母乳喂养的乳汁CMV-DNA检测呈阳性。11例婴儿19只眼底表现为不同程度的视网膜的点片状变性，更昔洛韦等治疗后视网膜病灶均明显好转，未见明显的并发症。
结论
小婴儿巨细胞病毒性视网膜炎是一种少见的疾病，婴儿期起病隐匿，诊断率较低，应引起足够的认识，早诊断，早治疗，提高患儿的生活质量。

关键词: 巨细胞病毒性视网膜炎, 治疗, 婴儿

Abstract:
Objective
To explore the clinical features, pathogenesis, diagnostic criteria and treatment strategy of cytomegalovirus retinitis(CMVR) in infants.
Methods
A retrospective analysis was performed based on the clinical data of 11 infants with CMVR having received treatment in our department from August 2015 to June 2018. The clinical features, treatment and prognosis were summarized and analyzed by reviewing the relevant literature.
Results
Seven infants with CMVR were female and 4 were male, aged 1 month to 8 months; 9 infants with cough or fever as firstonset symptom and 2 with diarrhea as firstonset symptom were hospitalized; serum CMV-DNA of 11 infants and breast milk CMV-DNA 11 breastfed infants were positive. In 11 infants with CMVR 19 eyes had varying degrees of degeneration of retinal spots, which were significantly improved after treatment with ganciclovir, and no obvious complications were observed.
Conclusion
Cytomegalovirus retinitis is an extremely rare disease with insidious onset and low diagnostic rate in infancy. The disease should arouse adequate awareness, in order to improve the quality of life of children by early diagnosis and treatment.

Key words: Cytomegalovirus retinitis, Treatment, Infants