关键词: 过敏性紫癜, 幽门螺旋杆菌, 肾功能损伤发生率, 肾功能好转率

Abstract:
Objective
To investigate the effect of Helicobacter pylori infection on renal function in children with Henoch-Schonlein purpura.
Methods
A total of 218 children with Henoch-Schonlein purpura admitted to Shenyang Children's Hospital from January 2016 to January 2018 were selected and divided into infection group(68 patients) and non-infection group(150 patients) according to whether they were infected with Helicobacter pylori. Helicobacter pylori eradication was performed in children of the infection group. The incidence of renal function injury and the rate of renal function improvement were compared between the two groups.
Results
The incidence of renal function injury in the infection group was 58.9%(40/68), which was significantly higher than that in the non-infection group［(34.7%(52/150)］, and the difference was statistically significant(P<0.05). In the infection group, there were 40 cases of renal damage, and 30 cases were turned negative after treatment, while 10 cases were not turned negative. The renal function improvement rate in negative children was 86.7% (26/30), which was significantly higher than that of 50.0%(5/10) in the children who were not turned negative, and the difference was statistically significant(P<0.05).
Conclusion
The renal function of children with Henoch-Schonlein purpura may be damaged to some extent after the infection of helicobacter pylori. After being treated in time, the damage can be improved and gradually the children can have normal renal function.

Key words: Helicobacter pylori, Henoch-Schonlein purpura, Incidence of renal function damag, Rate of renal function improvement