ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (1): 57-60.doi: 10.3969/j.issn.1674-3865.2017.01.018

• 临床研究 • 上一篇    下一篇

中西医结合及早期康复训练治疗新生儿缺氧缺血性脑病疗效观察

赵书琳，魏丽芳   

  1. 745000 甘肃 庆阳，庆阳市中医医院儿科(赵书琳)；庆阳市人民医院骨科(魏丽芳)
  • 出版日期:2017-02-25 发布日期:2017-12-18
  • 通讯作者: 魏丽芳，E-mail：429272063@qq.com
  • 作者简介:赵书琳(1971-)，男，主治医师。研究方向：小儿神经系统疾病诊断及治疗

Combined traditional Chinese and western medicine along with early rehabilitation training for neonatal hypoxic ischemic encephalopathy

ZHAO Shulin，WEI Lifang   

  1. Qingyang TCM Hospital，Qingyang 745000，China
  • Online:2017-02-25 Published:2017-12-18

PDF (PC)

137

摘要： 目的:观察中西医结合及早期康复训练治疗新生儿缺氧缺血性脑病临床疗效。
方法:2012年1月至2015年1月庆阳市中医医院儿科收治住院的中、重度HIE患儿152例，随机分为观察组和对照组各76例。对照组早期均进行吸氧、镇静、利尿、降颅压、有效控制惊厥等对症支持治疗，病情稳定后给予注射用脑蛋白水解物和单唾液酸四己糖神经节苷脂注射液静脉滴注。观察组在对照组治疗的基础上运用中医辨病辨证依据加用中药治疗并进行早期康复训练。日龄3 d、14 d、28 d做神经行为评分(NBNA)，评价两组患儿治疗前后NBNA评分；分别于3、6、9、12、18个月时作智能发育测定；治疗结束时观察比较两组临床疗效。
结果:观察组总有效率为92.1%(70/76)，高于对照组78.9%(60/76)，差异有统计学意义(P<0.05)。两组治疗后NBNA评分均较治疗前明显改善，差异有统计学意义(P<0.05)；观察组治疗后NBNA评分均高于对照组，差异有统计学意义(P<0.01)。两组治疗后发育商评分均较治疗前明显改善，差异有统计学意义(P<0.01)，观察组发育商评分改善较对照组更显著，差异有统计学意义(P<0.01)。
结论:中西医结合及早期康复训练治疗新生儿缺氧缺血性脑病疗效确切。

关键词: 缺氧缺血性脑病, 中西医结合, 早期康复训练, 婴儿, 新生

Abstract: Objective:To observe the clinical effect of integrated traditional Chinese and Western medicine and early rehabilitation training in the treatment of neonatal hypoxic ischemic encephalopathy.
Methods:Totally 152 cases of hypoxic ischemic encephalopathy were randomly divided into treatment group and control group, 76 cases in each group. In the early stage, oxygen inhalation, sedation, dieresis, intracranial pressure reduction, control of seizures and other symptomatic support therapies were given in both of the groups. In the stable stage, patients in the control group were given cerebroprotein hydrolysate for injection and monosialo four hexose ganglioside injection. In the treatment group, besides cerebroprotein hydrolysate for injection and monosialo four hexose ganglioside injection, patients were given traditional Chinese medicine treatment based on pattern differentiation and early rehabilitation training. NBNA was performed on 3 d,14 d and 28 d respectively and compare the NBNA of the two groups before and after treatment. Intelligence development was determined respectively at 3,6,9,12 and 18 months. Observe and compare the clinical effect in the two groups after treatment.
Results:The total effective rate was 92.1% in the treatment group, and 78.9% in the control group, the difference of which was statistically significant (P<0.05).The NBNA was significantly improved in the two groups after treatment, and the difference was of statistical significance(P<0.05). The NBNA was higher in the observation group than in the control group with statistical difference(P<0.01). After treatment the development score was significantly improved in both groups, and there was statistical difference compared with that before treatment(P<0.01),the score improvement was more significant in the observation group,the difference being statistically significant(P<0.01).
Conclusion:The combination of traditional Chinese and Western medicine and early rehabilitation training is effective in the treatment of neonatal hypoxic ischemic encephalopathy.

Key words: Integrated medicine, Early rehabilitation training, Neonatal hypoxic ischemic encephalopathy, Baby,newborn