ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (1): 65-67.doi: 10.3969/j.issn.1674-3865.2017.01.020

• 临床研究 • 上一篇    下一篇

布地奈德雾化吸入治疗新生儿肺炎的临床价值分析

李迪   

  1. 114014 辽宁 鞍山，鞍山市妇儿医院儿科
  • 出版日期:2017-02-25 发布日期:2017-12-18
  • 作者简介:李迪(1966-)，女，副主任医师。研究方向：小儿呼吸系统疾病的诊治，E-mail：lidsdgs@163.com

Analysis of the clinical value of budesonide inhalation therapy for neonatal pneumonia

LI Di   

  1. Anshan Maternal and Children's Hospital, Anshan 114014, China
  • Online:2017-02-25 Published:2017-12-18

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摘要： 目的:观察布地奈德雾化吸入治疗新生儿肺炎的临床应用价值。
方法:2010年10月至2012年11月鞍山市妇儿医院儿科收治住院的新生儿肺炎98例，随机分为观察组52例与对照组46例。对照组采用常规治疗，观察组在常规治疗的基础上雾化吸入布地奈德，持续治疗1周。比较两组患儿治疗效果及治疗前后二氧化碳分压、氧合指数情况，呼吸困难、肺部啰音消失时间、住院时间。
结果:观察组总有效率为96.2%(50/52)，高于对照组80.4%(37/46)，差异有统计学意义(P<0.05)。观察组治疗后二氧化碳分压低于对照组，氧合指数高于对照组，差异有统计学意义(P<0.05)。观察组呼吸困难、肺部啰音消失时间及住院时间均低于对照组，差异有统计学意义(P<0.05)。
结论:常规方式联合雾化吸入布地奈德能显著改善新生儿肺炎患者的临床症状，提高临床疗效，改善预后。

关键词: 新生儿肺炎, 布地奈德, 雾化吸入, 血气指数

Abstract: Objective:To observe the clinical value of budesonide inhalation therapy for neonatal pneumonia.
Methods:A total of 98 cases of neonatal pneumonia were treated in Anshan Maternal and Children's Hospital from Oct. 2010 to Nov. 2012, and they were divided into two groups: 52 cases in observation group and 46 cases in control group. The routine treatment was given to the control group，while for the observation group, budesonide inhalation therapy was also performed besides routine treatment; the treatment lasted for 1 week. Compare the treatment results between the two groups, and carbon dioxide partial pressure, oxygenation index, dyspnea, time of pulmonary rales disappearing and length of hospital stay were also compared before and after treatment.
Results:The total effective rate of observation group was 96.2%(50/52), which was higher than that of the control group 80.4%(37/46), and there was statistical difference(P<0.05). After treatment, the CO2 partial pressure in observation group was lower than that in control group, while oxygenation index was higher, both differences being statistical(P<0.05). Number of dyspnea, time of pulmonary rales disappearing and length of hospital stay of observation group were all lower than those of control group, and the difference was statistical(P<0.05).
Conclusion:Routine treatment combined with budesonide inhalation can significantly improve the clinical symptoms of neonates with pneumonia, which increases the clinical effect and helps to achieve a better prognosis.

Key words: Neonatal pneumonia, Budesonide, Atomized inhalation, Blood gas index