ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (4): 435-437.doi: 10.3969/j.issn.1674-3865.2016.04.021

• 临床研究 • 上一篇    下一篇

单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病的疗效观察

王书华   

  1. 473000 河南 南阳，南阳市第一人民医院急诊儿科
  • 出版日期:2016-08-25 发布日期:2018-11-19
  • 作者简介:王书华(1969-)，男，主治医师。研究方向：小儿血液病、新生儿重症的诊治，E-mail：ffbbdyx123@163.com

Curative effect and safety of Monosialotetrahexosylganglioside in the treatment of neonatal hypoxic ischemic encephalopathy

WANG Shuhua   

  1. Emergency Department of Pediatrics，the First People's Hospital of Nanyang，Nanyang 473000，China.
  • Online:2016-08-25 Published:2018-11-19

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摘要：
目的：观察新生儿缺氧缺血性脑病患儿采用单唾液酸四己糖神经节苷脂治疗的临床效果。
方法：2013年3月至2014年3月南阳市第一人民医院儿科收治住院的缺氧缺血性脑病新生儿108例，随机分为对照组和观察组各54例。对照组入院后给予降低颅内压、维持水电解质平衡、控制惊厥、维持良好通气等常规治疗措施。观察组在对照组治疗基础上给予单唾液酸四己糖神经节苷脂缓慢静脉滴注，每日1次，连续治疗10 d。观察两组疗效、治疗前后新生儿行为神经评分测定(NBNA)评分、临床体征(吸吮能力、原始反射及肌张力、意识)恢复情况。
结果：观察组总有效率为92.6%(50/54)，显著高于对照组75.9%(41/54)，差异有统计学意义(P<0.05)。观察组患儿临床吸吮能力、意识、原始反射、肌张力恢复时间显著短于对照组，差异有统计学意义(P<0.05)。治疗后观察组患儿NBNA评分显著高于对照组，差异有统计学意义(P<0.05)。
结论：新生儿缺氧缺血性脑病采用单唾液酸四己糖神经节苷脂治疗，有效促进了患儿神经功能的恢复，缩短了临床治疗时间，促进了临床治疗效果，值得推广应用。

关键词: 缺氧缺血性脑病, 新生儿神经评分, 单唾液酸四己糖神经节苷脂, 临床效果

Abstract:


Objective：To study the clinical effect of Monosialotetrahexosylganglioside in treatment of the neonatal hypoxic ischemic encephalopathy(HIE).
Methods：Totally 108 HIE neonates were randomly divided into control group(54 cases) and treatment group(54 cases). The control group was given the following routine treatment: lowering the intracranial pressure, keeping the water and dielectric balance, control convulsion, and maintaining good ventilation. The observation group was given the same treatment; in addition, monosialotetrahexosylganglioside was given by intravenous dripping, once a day, for 10 days continuously. Observe the therapeutic effect of the two groups as well as the NBNA score and the recovery of clinical signs(sucking, primary reflex, muscle tone and consciousness).
Results：The total effective rate of the observation group was 92.6%(50/54), significantly higher than that of the control group(75.9%,41/54)(P<0.05). The recovery time of observation group was significantly shorter than the control group(P<0.05). NBNA score was significantly higher in the observation group than in the control group after treatment.
Conclusion：For HIE neonates, monosialotetrahexosylganglioside can efficiently promote the recovery of neurological function, shorten the clinical treatment time, and improve the clinical treatment effect, which is worthy of promotion and application.

Key words: HIE, NBNA, Monosialotetrahexosylganglioside, Clinical effect