ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2015, Vol. 7 ›› Issue (6): 609-611.doi: 10.3969/j.issn.1674-3865.2015.06.027

• 临床研究 • 上一篇    下一篇

早产儿医院感染早期临床特征分析

连喜院   

  1. 744000 甘肃 平凉,平凉市人民医院新生儿科
  • 出版日期:2015-12-25 发布日期:2018-11-19
  • 作者简介:连喜院(1974-),男,副主任医师。研究方向：新生儿医院感染,E-mail：tqsa111@126.com

Early clinical characteristics of nosocomial infection in premature infants

LIAN Xiyuan   

  1. Department of Neonatology, Pingliang People's Hospital, Pingliang 744000,China.
  • Online:2015-12-25 Published:2018-11-19

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摘要： 目的: 观察早产儿医院感染早期的临床特征。
方法: 2010-04/2013-11平凉市人民医院新生儿科收住的早产儿354例，根据血常规、超敏反应蛋白、降钙素原的检测结果,对早期感染(24 h内)出现的临床症状进行分析。按照是否发生医院感染分为感染组206例,非感染组148例。将发热、呼吸暂停、黄疸等16项因素视为可疑早期临床特征,应用统计学方法分析明确早期临床特征。
结果: 呼吸暂停、胃潴留、呼吸急促、心率增快、呕吐、腹胀、发热、体温不升、黄疸9项临床表现与早期临床特征相关；进一步多因素logistic回归分析显示,呼吸暂停(OR=0.288,95% CI 0.065~0.795)及心率增快(OR=0.068,95% CI 0.027~0.168)为早产儿医院感染的早期临床特征。
结论: 心率增快、呼吸暂停为早产儿医院感染常见,且最早出现的临床表现。

关键词: 医院感染, 婴儿, 早产, 发热, 腹泻, 呼吸暂停

Abstract:
Objective：To observe the early clinical characteristics of nosocomial infection in premature infants.
Methods：A total of 354 patients, who were hospitalized within 24 h of birth, stayed in the hospital for ＞48 h and had not experienced prenatal bacterial infection, were selected. The clinical symptoms of early infection (within 24 h) were analyzed based on hematology, highsensitivity reactive protein and calcitonin tests. Based on the presence or absence of nosocomial infection, patients were divided into the infection group including 206 patients and the non-infection group including 148 patients. Taking the 16 factors, including pyrexia, apnoea, and jaundice, as suspicious early clinical characteristics, the early clinical characteristics were determined using Chi-square test and multivariate stepwise logistic regression.
Results：Nine clinical manifestations, including apnoea, gastric retention, shortness of breath, increased heart rate, vomiting, abdominal distension, pyrexia, body temperature failing to rise, and jaundice, were assessed as correlated with the early clinical characteristics; further multivariate logistic regression identified apnoea（OR=0.288，95%CI 0.065~0.795） and increased heart rate （OR=0.068，95% CI 0.027~0.168） as the early clinical characteristics of nosocomial infection in premature infants.
Conclusion：Increased heart rate and apnoea are the most common and earliest clinical manifestations of nosocomial infection in premature infants.

Key words: Nosocomial infection, Infant,, premature, Pyrexia, Diarrhea, Apnoea