ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (6): 480-482.doi: 10.3969/j.issn.1674-3865.2017.06.006

• 临床研究 • 上一篇    下一篇

喜炎平联合利巴韦林治疗小儿手足口病疗效观察及其安全性

姜丽   

  1. 110034 沈阳,沈阳市儿童医院内五科
  • 出版日期:2017-12-25 发布日期:2018-11-19
  • 作者简介:姜丽(1983-),女,主治医师。研究方向:小儿内科疾病的诊治,E-mail:1796185318@qq.com

Effect and safety of Xiyanping combined with ribavirin in the treatment of HFMD children#br#

JIANG Li   

  1. The Fifth Internal Medical Department of Shenyang Children's Hospital,Shenyang 110034,China
  • Online:2017-12-25 Published:2018-11-19

摘要:
目的
观察喜炎平联合利巴韦林治疗小儿手足口病的临床疗效及其安全性。
方法
选择2013年2月至2016年4月沈阳市儿童医院内五科收治的手足口病患儿70例为研究对象,随机分为观察组39例和对照组31例。对照组采用利巴韦林进行治疗;观察组在对照组治疗基础上联合喜炎平进行治疗。观察两组临床疗效;疱疹消失时间、完全退热时间、咳嗽消失时间、咽痛消失时间;3 d后检测肌酸激酶同工酶(CK-MB)水平;不良反应发生率、转为重症率、并发症发生率。
结果
两组患儿临床疗效比较差异无统计学意义(P>0.05)。观察组退疹时间、完全退热时间、咳嗽消失时间、咽痛消失时间、治疗后CK-MB水平显著低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率、并发症发生率、重症化率比较差异均无统计学意义(P>0.05)。
结论
喜炎平与利巴韦林联合治疗小儿手足口病疗效可靠,安全性高。

关键词: 手足口病, 疗效, 喜炎平, 儿童

Abstract:
Objective
To observe the clinical effect and the safety of Xiyanping combined with ribavirin in the treatment of children with hand-foot-mouth disease(HFMD).
Methods
A total of 70 HFMD children were included as the research subjects,who were treated in our hospital from Feb. 2013 to Apr. 2016,and they were randomly divided into observation group(39 cases)and control group(31 cases).Both groups were treated with ribavirin,and Xiyanping was given to the children in the observation group. Observe the clinical effect in the two groups, as well as the time of herpes disappearance,fever abatement,cough relief and disappearance of sore throat. After 3 days,the CK-MB level,the incidence of adverse reactions,the rate of turning into critical condition and the complication rate were determined.
Results
There was no statistical difference in the clinical effect between the two groups (P>0.05).The time of herpes disappearance,fever abatement,cough relief and the disappearance of sore throat was significantly shorter in the observation group,and the CK-MB level after treatment was significantly lower,the difference being statistical (P<0.05). There was no statistical difference in the incidence of adverse reactions,complications and the rate of turning into critical condition (P>0.05).
Conclusion
Xiyanping combined with ribavirin has significant effect in the treatment of children with hand-foot-mouth disease,and it's also very safe.

Key words: Hand-foot-mouth disease, Effect, Xiyanping, Child