关键词: 缺铁性贫血, 元素铁, 阶段性, 婴幼儿

Abstract:
Objective
To study the clinical effect of modifying iron phase-supplement treatment for infants with nutritional iron-deficiency anemia.
Methods
A total of 34 children with moderate-severe iron-deficiency anemia were chosen as the control group, who were treated in Changshu TCM Hospital from Feb. 2000 to Oct. 2001.A total of 169 children with moderate-severe iron-deficiency anemia were included as the observation group, who were treated from June 2005 to June 2013.In the observation group, ferrous succinate tablet at 3-4 mg/(kg·d)(divided into two times) for those children with hemoglobin under 90 g/L. at the first phase, and at the second phase, ferrous succinate tablet was given at 3-4 mg/(kg·week) for those with hemoglobin between 90 g/L and 110 g/L, once a week, until the RDW was less than 14.6%. In the control group, ferrous succinate tablet was taken at 5 mg/(kg·d)(divided into two times) for those with hemoglobin under 90 g/L at the first phase, and at second phase, ferrous succinate tablet was given at 3-4 mg/(kg·d)(divided into two times) for those with hemoglobin between 90 g/L and 110 g/L; at the third phase, ferrous succinate tablet was taken at 3 mg/a time, two time a day, for those with hemoglobin over 110 g/L, until the RDW was under 14.6%.In the observation group, blood routine and reticulocytes were examined in the first week of treatment; after that, blood routine examination was performed once a week for those with hemoglobin under 90 g/L, once in two weeks for those between 90 g/L and 110 g/L, and once in four weeks for those over 110 g/L until the RDW was under 14.6%. In the control group, blood routine and reticulocytes were examined in the first week of treatment, and after that blood routine examination was performed once in two weeks. The time of RBC-related parameters reaching the standard and the adverse reactions in both groups at the second phase were observed.
Results
There was no statistical difference in hemoglobin or the time of MCV and RDW reaching standard between the two groups after treatment（P>0.05）. The appetite was obviously improved in the first week in both groups; 3 to 5 day after taking medicine, there was black feces. Nausia occurred in 17 cases at the first phase in observation group, but no nausia, abdominal pain or decreased appetite at the second phase. There were 8 cases of abdominal pain, nausia and vomiting in the control group.
Conclusion
The modified treatment achieves similar clinical effect to the original one, with fever adverse reactions and higher compliance of parents, and it is easier for physicians to use and is more suitable to be clinically applied.

Key words: Iron-deficiency anemia, Iron element, Phases, Infants