ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (3): 213-215.doi: 10.3969/j.issn.1674-3865.2018.03.009

• 临床研究 • 上一篇    下一篇

布拉氏酵母菌联合复方丁香开胃贴佐治手足口病胃肠道症状研究

王屹,滕华   

  1. 116012 辽宁 大连,大连医科大学附属大连市儿童医院感染疾病科
  • 出版日期:2018-06-25 发布日期:2018-11-19
  • 通讯作者: 王屹,E-mail:46682345@qq.com
  • 作者简介:王屹(1983-),男,医学硕士,主治医师。研究方向:儿童呼吸系统疾病和感染性疾病的诊治

Research in the gastrointestinal symptoms of hand-foot-mouth disease treated with Saccharomyces boulardii and compound clove appetizing paste

WANG Yi,TENG Hua   

  1. Dalian Children's Hospital of Dalian Medical University,Dalian 116012,China
  • Online:2018-06-25 Published:2018-11-19

摘要:
目的
观察布拉氏酵母菌联合复方丁香开胃贴佐治手足口病胃肠道症状临床疗效。
方法
选择2016年6月至9月大连医科大学附属大连市儿童医院感染疾病科收治的手足口病患儿220例为研究对象,随机分为观察组和对照组各110例。对照组予抗病毒或联合抗细菌等治疗,观察组在对照组治疗基础上给予布拉氏酵母菌联合复方丁香开胃贴治疗,疗程6 d,比较两组患儿消化道症状发生率及不良反应。
结果
对照组12例以及观察组14例在随后治疗中出现手足口病重症并发症转入本院重症监护病房而退出研究。对照组食欲不振、恶心呕吐、腹痛、腹泻、腹胀、大便干燥临床症状体征发生率分别为65.3%(64/98)、42.9%(42/98)、46.9%(46/98)、34.7%(34/98)、36.7%(36/98)和22.4%(22/98),低于观察组29.2%(28/96)、18.8%(18/96)、12.5%(12/96)、14.6%(14/96)、13.5%(13/96)和8.3%(8/96),差异有统计学意义(P<0.05)。观察组仅有6例患儿因复方丁香开胃贴使用出现肚脐周围局部皮肤潮红,无皮疹和水疱,停药后48 h内好转,无其他不良反应发生。
结论
布拉氏酵母菌联合复方丁香开胃贴可有效降低手足口病患儿消化道症状发生率,值得临床推荐使用。

关键词: 手足口病, 布拉氏酵母菌, 复方丁香开胃贴, 儿童

Abstract:
Objective
To observe the clinical effect of Saccharomyces boulardii and compound clove appetizing paste in the treatment of gastrointestinal symptoms of hand-foot-mouth disease.
Methods
Totally 220 children with hand-foot-mouth disease hospitalized in Dalian Children's Hospital Affiliated to Dalian Medical University from June to September in 2016 were selected as the subjects. They were randomly divided into the observation group and the control group, 110 cases in each group. Both groups were treated with antiviral or combined antibiotics. The observation group was also treated with Saccharomyces boulardii and compound clove appetizing paste for 6 days. The incidence of gastrointestinal symptoms and adverse reactions were compared between the two groups.
Results:Twelve cases of the control group and 14 cases of the observation group had severe complications of hand-foot-mouth disease(HFMD) and withdrew from the study. The incidence of inappetence, nausea, vomiting, abdominal pain, diarrhea, abdominal distension and dry stool was 65.3%(64/98), 42.9%(42/98), 46.9%(46/98), 34.7%(34/98), 36.7%(36/98)and 22.4%(22/98)respectively in control group, which was higher than that of the observation group[(29.2%,28/96),(18.8%,18/96),(12.5%,12/96), (14.6%,14/96),(13.5%,13/96) and (8.3%,8/96)].The difference was statistically significant(P<0.05).In the observation group, only 6 cases had redness of skin around the navel due to the compound clove appetizing paste, no rash or blister. Skin redness was relieved within 48 hours of termination of drug use, and no other adverse reactions occurred.
Conclusion:Saccharomyces boulardii and compound clove appetizing paste can effectively reduce the incidence of gastrointestinal symptoms in children with hand-foot-mouth disease. The therapy is worth clinically recommending and applying.

Key words: Hand-foot-mouth disease, Saccharomyces boulardii, Compound clove appetizing paste, Children