Abstract:
Objective
To investigate the efficacy of gamma globulin combined with methylprednisolone in the treatment of immune thrombocytopenia.
Methods
Totally 106 children with immune thrombocytopenia admitted to Hunan Children's Hospital from August 2016 to December 2017 were randomly divided into observation group and control group, with 53 cases in each group. The control group was treated with methylprednisolone pulse therapy, while the observation group was treated with intravenous gamma globulin combined with methylprednisolone. The clinical effects of the two groups were observed after 3 weeks of treatment. The platelet count, hemoglobin, white blood cell count, platelet recovery time and hemorrhage stopping time were compared between the two groups. The recurrence rate after 6 months of follow-up and the incidence of adverse reactions during the treatment were observed, including Coxin syndrome, headache, nausea and so on.
Results
The total effective rate of observation group was 94.34%(50/53), which was significantly higher than that of control group(73.58%,39/53), and the difference was statistically significant(P<0.05). After treatment, the platelet count of the observation group was significantly higher than that of the control group, and the difference was statistically significant(P<0.05).The platelet recovery time and hemorrhage stopping time of observation group were significantly shorter than those of control group(P<0.05).The hemoglobin and white blood cell count were significantly lower in the observation group than in the control group(P<0.05). The recurrence rate of the observation group was 5.66%(3/53) after 6 months of followup, which was significantly lower than that of the control group(18.86%,10/53), and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).
ConclusionIntravenous gamma globulin combined with methylprednisolone pulse therapy for children with immune thrombocytopenia can achieve significant effects, which helps to improve the condition of children and is worth popularization and application.

Key words: Gamma globulin, Methylprednisolone shock, Immune thrombocytopenia, Children