Abstract:

Objective
To explore the difference of gene expression between autistic and normal children.
Methods
Totally 30 autistic children in Shenzhen Longgang District Maternal and Child Health Care Hospital from June 2017 to June 2018 were included as the observation group and 20 healthy children as the control group. The blood samples of all subjects were collected and DNA extractions were examined with DNA microarray. The signals were analyzed with copy number.
Results
The gene spectrum of 3 SNP locations（re2711888，rs6967728，rs756505） were compared. The results showed that there was no statistical difference in gene expression spectrum between autistic and normal children（P>0.05）.
Conclusion
There is no notable difference in the expression of 3 candidate genes in autistic children.

Key words: Autism spectrum disorder, DNA microarray, Copy number analysis, Children