Abstract:
Objective
To investigate the effect of azithromycin combined with montelukast sodium on children with asthmatic bronchitis and its effect on inflammation level.
Methods
Eighty-seven children with asthmatic bronchitis were divided into two groups by random number table method; 43 patients in the single-agent group were given intravenous infusion of azithromycin, and 44 patients in the combination group was treated with montelukast sodium orally in addition to azithromycin. The treatment lasted for one month as a course. Observe the clinical effects in the two groups, including the relief time of cough, fever, wheezing and wheezing rales as well as the length of hospital stay; for inflammation level, detect the level of IL-10, IL-12,ECP and LTE4 in the peripheral blood.
Results
The total effective rate of combination group was 93.18%(41/44),significantly  higher than that of the single-agent group（76.74%,33/43),and the difference was statistically significant (P<0.05). The relief time of fever, cough, wheezing and wheezing rales as well as the length of hospital stay was shorter in the combination group than in the single-agent group (P<0.05). After one month of treatment, the level of IL-10, ECP and LTE4 was lower in the combination group than in the single-agent group, while the level of IL-12 was higher(P<0.05).
Conclusion
Azithromycin combined with montelukast sodium in children with asthmatic bronchitis can rapidly improve the symptoms, signs and inflammation, and the effect is remarkable.

Key words: Asthmatic bronchitis, Azithromycin, Montelukast sodium, Children