ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2019, Vol. 11 ›› Issue (4): 356-358.doi: 10.3969/j.issn.1674-3865.2019.04.022

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Effect analysis of modified Zhibai Dihuang pill on children with idiopathic precocious puberty

ZHANG Suihong   

  1. Puning Overseas Chinese Hospital,Jieyang 515300,China
  • Online:2019-08-25 Published:2019-09-18

Abstract:
Objective
To explore the therapeutic effect of modified Zhibai Dihuang pill in treating children with idiopathic precocious puberty.
Methods
Totally 200 cases of children with idiopathic precocious puberty admitted to Puning Overseas Chinese Hospital from November 2016 to December 2018 were selected as research subjects and were randomly divided into control group and observation group, 100 cases in each group. Control group was given triptorelin, while observation group was given modified Zhibai Dihuang pill. The height, the ratio of bone age with age(BA/CA), nucleus diameter of left breast, nuclear diameter of right breast and follicle diameter, serum levels of folliclestimulating hormone(FSH), estradiol(E2) and serum luteinizing hormone(LH), and serum levels of insulinlike growth factor 1(IGF-1) were compared between the two groups before and after treatment.
Results
There was no significant difference in height or BA/CA between the two groups after treatment compared with before treatment(P>0.05). After treatment, the diameter of left and right breast nucleus and follicle in the observation group were significantly smaller than those in the control group, with statistically significant differences(P<0.05). After treatment, the levels of FSH, E2 and LH in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05). There was no statistically significant difference in IGF-1 levels between the two groups(P>0.05).
Conclusion
Modified Zhibai Dihuang pill has significant effect on children with idiopathic precocious puberty, and can effectively improve the symptoms of children and reduce the level of sex hormones.

Key words: Idiopathic precocious puberty, Modified Zhibai rehmannia pill, Sex hormones, Curative effect, Children