ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2019, Vol. 11 ›› Issue (5): 394-400.doi: 10.3969/j.issn.1674-3865.2019.05.008

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Method of reinforcing earth to generate metal for asthma in remission in children: a systematic review and Meta-analysis

LI Lixiang, ZHANG Renpan, ZHANG Jingrong, CHEN Siwen   

  1. Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
  • Online:2019-11-01 Published:2019-11-08

Abstract: Objective
To systematically assess the effectiveness of the Method of Reinforcing Earth to Generate Metal (MREGM) for the treatment of asthma in remission in children.
Methods
Some databases including CNKI, Wanfang, CMB, PubMed and Cochrane were searched by two independent researchers for the related clinical randomized controlled trials(RCTs) about the MREGM and western medicines for treating asthma in remission. The search time was from the inception of the databases to January 1st, 2019. Metaanalysis was performed to analyze all the included data by using Review Manager 5.3.
Results
A total of 21 RCTs involving 1 483 patients were included in this meta-analysis. The results demonstrated that MREGM had better effects in increasing the total effective rates[RR=1.25, 95%CI(1.17, 1.32), P<0.000 01], decreasing the number of asthmatic attack[WMD = -0.65, 95%CI(-0.83, -0.46),P<0.000 01] ,increasing the TCM syndrome scores[SMD =-1.44, 95%CI(-1.81, -1.07),P<0.000 01], and improving pulmonary function and biochemical indexes than western medicine.
Conclusion
MREGM is more effective than western medicine in the treatment of childhood asthma in remission(lung-and-spleen-qi deficiency syndrome). However, due to the low quality of the trials included in this study, more high-quality RCTs are needed to further verify this conclusion.

Key words: Asthma, Method of Reinforcing Earth to Generate Metal, Remission period, Children, Meta-analysis