Abstract:
Objective
To explore the effects of Bufei Yiqi decoction in adjuvant therapy for child patients with bronchial asthma and its influence on levels of inflammatory factors.
-Methods
Totally 128 child patients with mild-to-moderate bronchial asthma who were treated in Nanyang Central Hospital from -January- 2018 to December 2018 were selected as study subjects and were randomly divided into observation group(64 cases) and control group(64 cases). Both groups were given budesonide and other antitussive and antiasthmatic, bronchus-dilating and anti-infective symptomatic supportive treatment, and observation group was also given modified Bufei Yiqi decoction. The clinical efficacy in the two groups was compared. The changes in lung function indexes (total airway resistance, central airway resistance, peripheral airway resistance) and levels of serum inflammatory factors ［C-reactive protein(CRP), eosinophil(EOS), interleukin-4(IL-4), interleukin-10(IL-10)］ were observed in the two groups before treatment and after 1 week of treatment.
Results
After 1 month of treatment, the total clinical effective rate in observation group was significantly higher than that in control group［96.8%(62/64) vs.87.5%(54/64)］(P<0.05). After 1 month of treatment, the central airway resistance and total airway resistance in the the two groups were significantly lower than those before treatment, while the peripheral airway resistance was higher; the central airway resistance and total airway resistance in observation group were significantly lower than those in control group, while the peripheral airway resistance was significantly higher(P<0.05). After 1 month of treatment, the levels of CRP, EOS and IL-4 in the two groups were significantly lower than those before treatment, while the IL-10 level was significantly higher(P<0.05). The levels of CRP, EOS and IL-4 in observation group were significantly lower in observation group than those in control group, while the IL-10 level was significantly higher(P<0.05).
Conclusion
Modified Bufei Yiqi decoction combined with budesonide has significant efficacy in the treatment of child patients with bronchial asthma, and it can effectively improve the clinical symptoms and enhance the lung function of child patients.

Key words: Bronchial asthma, Bufei Yiqi decoction, Lung function, Inflammatory factors, Children