Abstract:
Objective
To analyze the difference in the effect of ketogenic diet in the treatment of refractory epilepsy in children with different causes and seizure forms.
Methods
From November 2017 to November 2018, 50 patients with refractory epilepsy were treated with ketone-producing diet in our hospital and they were selected as the observation subjects, and were grouped according to different causes and seizure forms. According to the etiology, there were 25 cases in the epilepsy group with unknown cause and 25 cases in the symptomatic epilepsy group. According to the seizure form, there were 20 cases in the mixedseizure epilepsy group and 30 cases in the single-seizure epilepsy group. According to the different types of seizures, there were 10 cases in the epileptic spasm group and 40 in the nonepileptic spasm group. The ketogenic diet was started when the blood ketone was 2 mmol/L. At the same time, potassium bromate is administered, 0.5 g per day, and the compound vitamin mineral preparation was given at 6 g per day. The ratio of the fat in ketogenic diet to the protein and the carbohydrate was 4∶1 or 3∶1. The treatment time was more than 3 months, and the treatment effect was observed.
Results
The total effective rate of the patients in symptomatic epilepsy group was 80.0%(20/25), which was significantly higher than that of the epilepsy group with unknown cause(48.0%,12/25), and the difference was statistically significant(P<0.05). There was no significant difference in the total effective rate between the single-episode epilepsy group and the mixed-onset epilepsy group(P>0.05). The total effective rate of the epileptic spasm group was 80.0%(8/10), which was significantly higher than that of the non-epileptic spasm group(45.0%,18/40), and the difference was significant(P<0.05).
Conclusion
Ketogenic diet has high application value in the treatment children with refractory epilepsy. Here in this study it proved that the effect of ketogenic diet has no significant difference in epilepsy children with different seizure forms. The diet has better effect on the children with symptomatic epilepsy and the children with epileptic spasm.

Key words: Epilepsy, Ketogenic diet, Causes, Seizure form, Children