Abstract: Objective
To explore the clinical features of children with reversible splenial lesion syndrome and to improve the understanding of the diseases.
Methods
A total of 32 children hospitalized in Harbin Children's Hospital from Jan. 1,2016 to June 30,2018 were included, whose MRI examination suggested that they had splenial lesion. Clinical data, laboratory examination, imaging data and follow-up data of them were analyzed retrospectively.
Results
Among the 32 children, 17 were male and 15 were female. There were 22 infants and 10 children and adolescents. Of these children, 23 cases started with gastrointestinal symptoms, 5 cases with intracranial infection, and 4 cases with simple convulsion as the first symptom. There were 28 cases of viral infection and 4 cases of bacterial infection. Only splenium of corpus callosum was involved in 30 cases, while in two cases both the splenium and genu of corpus callosum and thalamus were involved. The clinical symptoms of 29 cases were relieved within 1 week, and the splenial lesion disappeared within 2 weeks after the MRI review. No lesion was found in two cases with previous CT of head.
Conclusion
Patients with gastrointestinal symptoms in early childhood, accompanied by convulsion symptoms, and viral infection as the main pathogen should be highly suspected of reversible splenial lesion syndrome. Even there were no lesions been found in the CT, it is also necessary to use the MRI.

Key words: Corpus Callosum, Reversible, Children