ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2020, Vol. 12 ›› Issue (5): 399-402.doi: 10.3969/j.issn.1674-3865.2020.05.009

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Correlation analysis of bone metabolism indexes in early neonates

  

  • Online:2020-10-25 Published:2020-11-28

Abstract: Objective To explore the correlation of bone metabolism indexes in early neonates to reduce the occurrence of metabolic osteopathy.
Methods A total of 121 early newborns were enrolled for the study, who were hospitalized in the Department of Neonatology of Zhuhai Hospital of Itegrated Traditional Chinese and Western Medicine from July 2018 to December 2019. The analysis of the correlation of the bone metabolism indexes were done, by detecting the serum concentrations of indexes of bone formation(ALP, PINP), indexes of bone absorption(β- CTX), indexes of bone nutrition(Ca2+, P, 25-(OH) D), and indexes of bone metabolism regulating hormone(PTH, CT).
Results The results of PINP, which exceeded the maximum range of detection reagent, were all greater than1 200.00 μg/L,so it was not included in the analysis. The results of ALP, β-CTX, Ca2+, P, 25-(OH)D, PTH and CT were (190.08±59.99)U/L, (0.85±0.33)μg/L, (2.41±0.17)mmol/L, (2.35±0.90)mmol/L, (12.76±4.98)μg/L, (32.02±27.20)ng/L, and (5.35±5.05)ng/L, respectively. Correlation analysis showed that ALP was positively correlated with PTH; β-CTX was positively correlated with CT, while negatively correlated with P; Ca2+ was positively correlated with 25-(OH)D, and P was positively correlated with PTH, while negatively correlated with CT; PTH was negatively correlated with CT.
Conclusion Bone metabolism is very active in neonates, and there is a complex correlation among bone metabolism indexes. Early newborns need to be supplemented with vitamin D and take enough calcium and phosphorus in order to increase bone mass reserve and reduce the occurrence of metabolic osteopathy.

Key words: nfant,newborn, Bone metabolism markers, Bone formation, Bone absorption, Bone nutrition