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ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Table of Content

    25 April 2019, Volume 11 Issue 2 Previous Issue    Next Issue
    Thoughts on building a biological sample bank of children's pulmonary diseases with traditional Chinese characteristics
    ZHANG Xiuying,WANG Xuefeng,QIU Mingke
    2019, 11 (2):  93-95.  doi: 10.3969/j.issn.1674-3865.2019.02.001
    Abstract ( 493 )   PDF (377KB) ( 113 )   Save

    Objective
    With the development of individualized treatment and transformational medicine, biological sample bank, as a bridge between clinical and scientific research transformation, has attracted more and more attention. Firstly, the current situation of the construction of biological sample bank at home and abroad is described. Secondly, the main points of the construction of biological sample bank of children's pulmonary diseases were summarized. Finally, the significance of the construction of biological sample bank with disciplinary characteristics was analyzed. By establishing a standardized biological sample bank of children's pulmonary diseases with disciplinary characteristics, we can enhance the construction of discipline connotation, and also provide an important guarantee for translational medicine
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    Analysis of the risk factors of pneumonia in intrinsic-quality children in Guangxi
    ZHOU Zhining,LI Jie, YAO Yongzhi,WANG Lining,LI Zhifeng,MENG Chunxue,YANG Liming,CAI Xiaojing,MO Xueying,LI Li,HUANG Zhibi,ZHANG Xiaochun,SUN Jichao,LIANG Tingjun,SU Wenjing
    2019, 11 (2):  96-100.  doi: 10.3969/j.issn.1674-3865.2019.02.002
    Abstract ( 515 )   PDF (552KB) ( 87 )   Save

    Objective
    To study the risk factors of community-acquired pneumonia(CAP) in intrinsic-quality children in Guangxi in order to provide clinical evidence-based basis for its prevention and treatment.
    Methods
    A questionnaire survey was performed in the children aged one to six years in the cities of Chenxi, Liuzhou, Beihai and Nanning as well as in Sanjiang county from April 2017 to September 2018.The dependent variable was whether the children had had CAP before, and the independent variable is the 39 possibilities of the intrinsic-quality children, the risk factors of CAP and the constitute type. The gradual Logistic regression analysis was made on the CAPrelated risk factors in these children.
    Results
    A total of 466 valid questionnaires were collected, among which there were 343 cases of intrinsic quality,104 cases combined with accumulation of heat, 66 cases with qi-deficiency, 38 with yin-deficiency,16 with phlegm-dampness, and 13 with yang-deficiency. In the 343 children,214(62.4%) had had CAP,129(37.6%) had had no CAP; in the 123 children with nonintrinsicquailty,38 had had CAP(30.9%),85 had had no CAP(69.1%), the gradual Logistic regression analysis showed that there was statistically significant relationship between intrinsicquality children with CAP and the following factors: history of asthma,recurrent respiratory tract infection, the basic diseases such as malnutrition, hospitalization history and use of antibiotics(P<0.05);the incidence of CAP in the intrinsic-quality children was  related to intrinsic quality combined with phlegm-dampness.
    Conclusion
    There may be close relationship between intrinsic quality and CAP in children; the risk factors of CAP in these children are:combination with asthma, recurrent respiratory tract infection, malnutrition and other basic diseases, and use of antibiotics; the incidence of CAP is higher in the children combined with phlegm-dampness than in those with other constitutions.
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    Regularity of sublingual collaterals in children with lobar pneumonia
    GUO Zheng,WANG Hai,ZHANG Yongzheng
    2019, 11 (2):  101-103.  doi: 10.3969/j.issn.1674-3865.2019.02.003
    Abstract ( 629 )   PDF (316KB) ( 92 )   Save

    Objective
    To observe the changes of sublingual collaterals in children with lobar pneumonia and their correlation with tongue texture and tongue coating.
    Methods
    From March 2018 to March 2019, 206 children with lobar pneumonia and 100 children with bronchial pneumonia were treated in the Department of Pediatrics, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, who were included in the study as lobar pneumonia group and bronchial pneumonia group. A total of 100 health children were chose as the normal control group. The abnormal distribution of sublingual collaterals was compared and analyzed among the three groups. Meanwhile, the tongue texture and tongue coating of children with lobar pneumonia were observed to analyze the correlation.
    Results
    The abnormality rate of sublingual collaterals was 61.7% in lobar pneumonia group, which was significantly higher than that in bronchopneumonia group and normal control group, and the difference was statistically significant(P<0.05). The abnormal sublingual collaterals in lobar pneumonia children were shown as red purple tongue and thick and greasy tongue coating.
    Conclusion
    The sublingual collaterals play a significant role in the diagnosis of the blood stasis sign in children with lobar pneumonia, and is a necessary supplement to tongue texture and tongue coating, which can further guide clinical practice.
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    Experience of Professor Wang Xuefeng in the treatment of bronchiolitis obliterans in children and analysis of cases
    ZHANG Lijia,WANG Xuefeng,SHAN Hongmei,ZHANG Xiuying
    2019, 11 (2):  104-107.  doi: 10.3969/j.issn.1674-3865.2019.02.004
    Abstract ( 486 )   PDF (528KB) ( 137 )   Save

    Bronchiolitis obliterans(BO) is a chronic airflow obstruction syndrome caused by bronchial inflammatory injury,with the most common prognosis of repeated lower respiratory tract infections or severe pneumonia in children. The child's condition is lingering and difficult to heal, the prognosis is poor, and the clinical treatment is relatively difficult. Professor Wang Xuefeng has been engaged in research on the prevention and treatment of children's pneumonia with traditional Chinese medicine for nearly 40 years. In recent years, with the change of etiology, there have been unique opinions on the diagnosis and treatment of BO in children, and the clinical effect is better. In this paper, two medical records are selected to discuss the principle, method and prescription of integrated traditional Chinese and western medicine for prevention and treatment of BO in children.
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    Effect of early intervention on the total volume of the myelinated fibers in the white matter of neonatal rat with brain injury due to intrauterine infection
    LI Peichun,LUO Nan,LI Xiaojie
    2019, 11 (2):  108-111.  doi: 10.3969/j.issn.1674-3865.2019.02.005
    Abstract ( 456 )   PDF (491KB) ( 96 )   Save

    Objective
    To study the effect of early intervention on the total volume of the myelinated fibers in the white matter of neonatal rat with brain injury due to intrauterine infection.
    Methods
    Prepare the models of brain injury due to intrauterine infection and divide them into two groups:30 Wistar rats at 17d of gestation were given abdominal injection of lipopolysaccharide[450 μg/(kg·d)] for 2 days in a row(the LPS group);6 rats were given the same amount of saline(the saline group). The rats in LPS group were divided randomly into intervention group and no-intervention group. Touching and environment stimulation was given to the intervention group at an early stage, and rehabilitation training at a late stage. The other groups were given conventional feeding. A quantitative research was performed on the total volume of the myelinated fibers in the white matter of the above groups by transmission electron microscope and stereological methods at 14d and 28d of delivery.
    Results
    (1)The total volume of myelinated fibers in saline group increased from 12.99 mm3 to 32.77 mm3,with an increase rate of 61.5%,from 14d to 28d after delivery(P<0.05). (2)Compared with the saline group, the total volume decreased by 43.5% at 14d after delivery in the no-intervention group, and 34.4% in the intervention group; there was no statistically significance difference in volume between intervention group and nointervention group(P>0.05). (3)On the 28th day after delivery, the total volume of myelinated fibers decreased by 81.3% in the no-intervention group and by 57.8% in the intervention group, compared with the saline group; there was statistical difference in the volume between intervention group and nointervention group(P<0.05).
    Conclusion
    (1)With age increasing, the total volume of myelinated fibers in normal white matter increases. (2)The brain injury due to intrauterine infection decreases the total volume of the myelinated fibers in white matter, and it becomes more significant with development. (3)Early intervention can increase the total volume of myelinated fibers in white matter.
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    Simultaneous determination of six components in Xiaoer Bushen Gubiao granule by HPLC
    YANG Hui,PAN Dongming,QI Huanyang,HUANG Yiqi, LUO Youhua, ZHANG Qingling,XUE Zheng, YU Jianer,CHU Kedan
    2019, 11 (2):  112-116.  doi: 10.3969/j.issn.1674-3865.2019.02.006
    Abstract ( 381 )   PDF (427KB) ( 163 )   Save

    Objective
    To establish a method for the simultaneous determination of six components (prim-O-glucosylcimifugin,calycosin-7-glucoside, 5-O-methylvisammioside, baicalin, psoralen and angelicin) in Xiaoer Bushen Gubiao granule by HPLC.
    Methods
    The chromatographic conditions were determined by high performance liquid chromatography with C18 column (250 mm×4.6 mm,5 μm),mobile phase being acetonitrile-0.2% formic acid aqueous for solution gradient elution; flow rate was 1.0 mL/min,and column temperature was 30 ℃, injection volume 10 μL; DAD detector was used with the detection wavelength being 254 nm and 280 nm.
    Results
    The six components were well separated and showed a good linear relationship with peak area (r≥0.999 0) within their respective concentration ranges. The average sample recovery rates of prim-O-glucosylcimifugin,calycosin-7-glucoside, 5-O-methylvisammioside, baicalin, psoralen and angelicin were 99.89%,101.86%,103.22%,99.59%,98.37%,98.12%,and RSD was 3.84%,2.80%,3.12%,4.29%,4.53% and 4.87%, respectively.
    Conclusion
    The method is accurate, simple, reproducible and sensitive. It can be used for the quality control of multi-components in Xiaoer Bushen Gubiao granule.
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    Clinical study on the Liujunzi decoction and Yupingfeng powder in the treatment of asthma children in the remission period
    LIU Yazun, ZHANG Hao,XUE Zheng, ZHANG Yiqun
    2019, 11 (2):  117-120.  doi: 10.3969/j.issn.1674-3865.2019.02.007
    Abstract ( 536 )   PDF (456KB) ( 77 )   Save

    Objective
    To study the effect of Liujunzi decoction and Yupingfeng powder on the TCM syndrome score, the C-ACT score and the pulmonary function in asthma children in remission with wind-phlegm inside and lung-spleen Qi-deficiency.
    Methods
    Totally 100 children who met the asthma diagnostic standards were selected and randomly divided into the control group and the treatment, with each group having 50 cases. In the control group, budesonide was given for 6 months, while in the treatment group, pulmicort was given for 6 months, combined with the Liujunzi decoction and Yupingfeng powder for 3 months. After 3 months and 6 months of treatment, TCM syndrome score, asthma control test(C-ACT) and pulmonary function were revalued.
    Results
    (1)TCM syndrome scores: after 3 months and 6 months of treatment, the improvement of TCM syndrome score in the treatment group were lower than that of the control group(P<0.05).(2)C-ACT score: after 3 months of treatment, C-ACT was similar in the two groups(P>0.05). At 6 months of treatment, the improvement in the treatment group was superior to that in the control group(P<0.05). (3)Pulmonary function: after 3 months and 6 months of treatment, the improvement of PEF, FVC, FEV1, FEF50 and FEF75 in the treatment group was better than that in the control group(P<0.05).
    ConclusionLiujunzi decoction and Yupingfeng powder can improve the symptoms of TCM syndrome, the asthma control test(C-ACT) score, and the function of lung ventilation in the children with asthma in remission period with wind-phlegm inside and lung-spleen Qi-deficiency.
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    Relationship between liver depression and sexual development in children with idiopathic precocious puberty
    GUO Lihua,WANG Juxia,AI Si
    2019, 11 (2):  121-124.  doi: 10.3969/j.issn.1674-3865.2019.02.008
    Abstract ( 468 )   PDF (402KB) ( 85 )   Save

    Objective
    To study the relationship between liver depression and sexual development in children with idiopathic precocious puberty.
    Methods
    Totally 35 girls with idiopathic precocious puberty, who were admitted to People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine from August to December, 2018,were selected as the research subjects(observation group). Thirty-one healthy girls of the same age were selected as the control group. According to the "Syndrome Differentiation School", we collect the four diagnosis information to get the integral and grade of liver depression, and the sex hormone levels of the two groups were measured to analyze the correlation between the integral of liver depression and sex hormone levels. The breast diameter, ovarian volume and uterine volume were measured in children with idiopathic precocious puberty, so as to explore their correlation with the integral and grade of liver depression.
    Results
    The FSH, LH and estradiol of the girls in the observation group and higher than those in the control group, while testosterone was lower. The difference was statistically significant(P<0.05). The integral of liver depression in the observation group was higher than that in the control group(P<0.05). There was no correlation between the integral of liver depression and the levels of sex hormones(FSH,LH,estradiol,testosterone), and there was no significant difference between the two groups(P>0.05). In the observation group, the integral of liver depression was positively correlated with breast diameter, ovarian volume and uterine volume, and the difference was statistically significant(P<0.01). The higher grade the liver depression, the higher the breast diameter, ovary volume and uterine volume, there were statistical differences among different liver depression grades(P<0.01).
    Conclusion
    Liver depression may be involved in the early occurrence of sexual development in children with idiopathic precocious puberty.
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    Research progress of language development assessment in children
    LIU Fang.
    2019, 11 (2):  125-129.  doi: 10.3969/j.issn.1674-3865.2019.02.009
    Abstract ( 445 )   PDF (555KB) ( 130 )   Save

    Language is a cognitive expression that reflects the human brain's thinking and psychological process. Language plays an important role in children's cognitive and social development. Children's language is an important aspect reflecting intelligence. Language development disorders are the most common disorders of childhood development. Early childhood language problems can be used as a vigilance indicator of the brain's overall dysplasia, and can be used as an indicator to predict the cognitive processing obstacles of children's brains now and in the future. Languageimpaired children routinely need to have their cognitive processing levels detected.
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    Mechanism of insect drugs in the treatment of Tourette's syndrome
    MAI Xiujing, XU Ke,HAN Xinmin
    2019, 11 (2):  129-132.  doi: 10.3969/j.issn.1674-3865.2019.02.010
    Abstract ( 391 )   PDF (550KB) ( 95 )   Save

    The common causes of Tourette's syndrome (TS) are imbalance and abnormal conduction of central neurotransmitters, imbalance of trace elements, allergic reactions, abnormal immune function, mental factors and genetic factors. Rich experience has been accumulated in the clinical TCM treatment for Tourette's disease, and insect drugs have also played a role in calming the liver and the wind, relieving phlegm and spasm, relaxing muscles and tendons, and nourishing the kidney and consolidating the constitution, which regulate the central nervous system, resist allergy, supplement trace elements, and improve immune function, etc. The analysis shows that insect drugs can reach any part and deals with any problem, having incomparable efficacy compared with plant drugs; clinical efficacy is significant. However, the following principles should be followed in the treatment: eliminating evil without hurting the health, being careful in allergic infants, and combining attack with supplement, in order to avoid improper compatibility and hindering the recovery of children.
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    Airway mucus hypersecretion from the perspective of traditional Chinese medicine
    GAO LYu,LIU Lina,SHI Zhenggang
    2019, 11 (2):  133-135.  doi: 10.3969/j.issn.1674-3865.2019.02.011
    Abstract ( 643 )   PDF (398KB) ( 72 )   Save

    Airway mucus hypersecretion is an important feature of respiratory diseases. In Chinese medicine airway mucus belongs to the category of "Jin", and hypersecretion of mucus in the airway belongs to the category of "Tan". The key to the pathogenesis of hypersecretion of mucus in the airway is the dysfunction of the lung-spleen-gut axis, and the lack of spleen method as the core. The treatment should focus on both the causes and symptoms, with the spleen method as the core, and the lung-spleen-gut axis as the key. A typical case is used as an example.
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    Discussion on the effect of Rhubarb in the treatment of children with pulmonary diseases
    GAO Chang,WU Zhenqi.
    2019, 11 (2):  136-139.  doi: 10.3969/j.issn.1674-3865.2019.02.012
    Abstract ( 438 )   PDF (553KB) ( 102 )   Save

    Rhubarb has always been an important medicine for doctors. It has good functions, for example, bringing forth the new and getting rid of the old, conducting circulation, regulating middle energizer and helping digestion, and it is widely used in pulmonary diseases. Chengqi decoction with its associated prescriptions and Dachaihu decoction are classical prescriptions for treatment of pulmonary diseases. We have gained a lot through modifying the decoction, and through the combination of oral administration with external application. Based on these prescriptions, the efficacy of rhubarb is discussed in this article. It may be the means of rushing down or clearing, but all of them reflect the excellent medication of doctors. These are worth our careful exploration and we hope to expand its clinical application.
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    Inhibitory effect of Xiao'er Zidian Zhenxiao granule on inflammation of human umbilical vein endothelial cells induced by serum IgA1 in children with HenochSchonlein purpura and its mechanism
    ZHU Haoyu,DUAN Xiaozheng,FENG Xiaochun
    2019, 11 (2):  139-143.  doi: 10.3969/j.issn.1674-3865.2019.02.013
    Abstract ( 447 )   PDF (581KB) ( 70 )   Save

    Objective
    To investigate the inhibitory effect of Xiao'er Zidian Zhenxiao granules on the inflammation of human umbilical venous endothelial cells(HUVECs) induced by serum IgA1 in children with HenochSchnlein purpura(HSP), and to clarify its mechanism.
    Methods
    HUVECs were used as the research subjects, serum IgA1 in HSP children and in healthy children were used to intervene, and different concentrations of Xiao'er Zidian Zhenxiao granules were added. They were divided into blank control group, normal control group, Henoch-Schonlein purpura group(HSP group) and the Xiao'er Zidian Zhenxiao granules groups(ZXKL groups)(the low-,medium-and high-concentration group, with the concentration being 25 mg/L, 50 mg/L and 100 mg/L respectively). After 24 hours of culturing in each group, TNF-α and IL-8 levels in the supernatant of each group were determined by enzyme-linked immunosorbent assay. Westernbolt was used to detect the expression of NF-κB protein in each group.
    Results
    The levels of TNF-α and IL-8 in the supernatant of each group were significantly higher in the HSP group than in the blank and normal control groups(P<0.001). Compared with the HSP group, the levels of TNF-α and IL-8 in the ZXKL groups decreased(P<0.05). The expression of P65 protein in HUVECs was detected by Western blot. Compared with the blank and normal control groups, the P65 protein level in the HSP group was significantly increased(P<0.05). Compared with the HSP group, the P65 protein level in the high-concentration ZXKL group(100 mg/L) was decreased(P<0.05).
    Conclusion
    Xiao'er Zidian Zhenxiao granules can decrease the phosphorylation of NF-κB signaling pathway P65 protein in HUVECs and reduce the secretion of related inflammatory cytokines(TNF-α and IL-8), thus effectively inhibiting the occurrence of cellular inflammatory responses.
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    Analysis of clinical features and risk factor of refractory Mycoplasma pneumoniae pneumonia
    QU Baina,CHI Lei,ZHU Ziwei,HUANG Yan.
    2019, 11 (2):  144-148.  doi: 10.3969/j.issn.1674-3865.2019.02.014
    Abstract ( 507 )   PDF (488KB) ( 82 )   Save

    Objective
    To analyze the clinical characteristics of refractory Mycoplasma pneumoniae pneumonia(RMPP) and general Mycoplasma pneumoniae pneumonia(GMPP) and investigate its high risk factors in order to provide a certain theoretical basis for early detection, early diagnosis, and early intervention of RMPP.
    Methods
    A total of 203 MMP children treated in Dalian Children's Hospital from October 2016 and September 2017 were chosen as the subjects, of whom there were 70 cases of RMPP and 133 cases of GMPP. The two groups of children were compared in clinical manifestation, imaging results and laboratory indicators, and the multifactor regression analysis was made.
    Results
    There was statistical difference between RMPP group and GMPP group in age of onset, fever duration, fever peak value, fever interval, proportion of symptoms complicating fever, length of hospital stay and the proportion of extrapulmonary complications(P<0.01). The level of serum Creactive protein and lactate dehydrogenase(LDH) was significantly higher in RMPP group than in GMPP group(P<0.01). There was no difference in WBC count or serum procalcitonin between the two groups(P>0.05). The proportion of children whose imaging shower to be lobar pneumonia and the proportion of children complicated with pleural effusion were significantly higher in RMPP group than in GMPP group, while the proportion of bronchopneumonia was significantly lower(P<0.01). The high risk factors of RMPP were fever duration, fever interval, symptoms complicating fever(being chilly, chills, etc.) and length of hospital stay.
    ConclusionThe longer the fever duration and the length of hospital stay, the shorter the fever interval, and the more symptoms complicating fever, the more probable the children get RMPP.
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    Observation on curative effect of purpura basic prescription in the treatment of children with cutaneous allergic purpura
    ZHAN Ke,ZHU Weina,ZHAO Aiping,XU Huan,LIU Ying,ZENG Siyao,ZHU Ling,YU Minfeng
    2019, 11 (2):  148-150.  doi: 10.3969/j.issn.1674-3865.2019.02.015
    Abstract ( 356 )   PDF (325KB) ( 133 )   Save

    Objective
    To observe the clinical effect of purpura basic prescription in the treatment of cutaneous allergic purpura in children.
    Methods
    A total of 120 children with cutaneous allergic purpura admitted to the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from August 2016 to August 2018 were randomly divided into observation group and control group with 60 cases in each group. The observation group was treated with basic prescription for purpura, while the control group was treated with routine drugs including 10% calcium gluconate injection, compound glycyrrhizin injection, cimetidine injection and loratadine granules, 2 weeks as a course of treatment. After 2 weeks of treatment, the clinical efficacy and the time of purpura subsidence of the two groups were observed; the patients were followed up for 3 months to observe the occurrence of kidney damage in the two groups.
    Results
    There was no significant difference in the total effective rate between the two groups after 2 weeks of treatment(P>0.05). The average time of purpura subsidence in the observation group was (5.56±2.03) days, which was significantly shorter than that in the control group (8.12±1.77) days, and the difference was statistically significant(P<0.05). During the 3month followup period, the incidence of kidney damage in the observation group was significantly lower than that in the control group(P<0.05).
    Conclusion
    The therapeutic effect of purpura basic prescription on children with cutaneous allergic purpura is satisfactory;in particular,the time of purpura subsidence is significantly short. It has a good longterm prognosis and can reduce the renal damage of children.
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    Retrospective study of modified Zidian formula combined with western medicine in the treatment of children with Henoch-Schonlein purpura
    LONG Junying,LIU Xiaoying,ZHU Yina
    2019, 11 (2):  151-154.  doi: 10.3969/j.issn.1674-3865.2019.02.016
    Abstract ( 423 )   PDF (438KB) ( 95 )   Save

    Objective
    To observe the clinical efficacy of modified Zidian formula combined with western medicine in the treatment of children with Henoch-Schonlein purpura, in order to provide clinical reference and optimization ideas for the diagnosis and treatment of the disease.
    Methods
    A retrospective study was performed on 121 children with Henoch-Schonlein purpura who were treated with modified Zidian formula combined with western medicine in Hubei Provincial Hospital of Traditional Chinese Medicine from January 2015 to June 2018. The patients were followed up for 2 weeks as evaluation point to observe the signs and symptoms before and after treatment. Take half a year as an evaluation point to observe the recurrence of rash and renal damage in children before and after treatment.
    Results
    After 2 weeks of treatment, the total effective rate on rash was 97.52%(118/121), and the total effective rate on refractory rash was 86.36%(19/22). After 2 weeks of treatment, the TCM syndrome major total points, minor total points and total points were lower than before treatment, and the difference was statistically significant(P<0.05). The total effective rate on TCM syndromes was 97.52%(118/121). There were 86 cases of recurrent rash after half a year of treatment, and the frequency of recurrence within half a year of treatment was significantly lower than that in the half a year before treatment, with statistically significant difference(P<0.05). There were 82 cases without renal damage before treatment, and 9 cases showed new renal damage in the half-year follow-up, with the incidence of renal damage being 10.98%(9/82).
    ConclusionModified Zidian formula combined with western medicine in the treatment of children with Henoch-Schonlein purpura can effectively alleviate the clinical symptoms, reduce the recurrence of skin rash, and reduce the possibility of allergic purpura renal damage, and it has a high safety.
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    Analysis of risk factors and clinical characteristics of ischemic stroke in children
    PENG Yani, ZHANG Xinping, XIAO Zhenghui.
    2019, 11 (2):  155-157.  doi: 10.3969/j.issn.1674-3865.2019.02.017
    Abstract ( 367 )   PDF (307KB) ( 104 )   Save

    Objective
    To investigate the risk factors and clinical characteristics of ischemic stroke(IS) in children.
    Methods
    Retrospective analysis was conducted in 169 children with ischemic stroke admitted to and treated in Hunan Children's Hospital from January 1, 2013, to September 30, 2018.
    Results
    Among the 169 cases, 96 cases were male and 73 cases were female. The median age of onset was 2.4±1.3 years old, and the first symptom were mostly convulsion, hemiplegia and language disorder. Common risk factors were infection, cerebral arteriopathy, trauma, heart disease and moyamoya disease, etc.
    ConclusionIschemic stroke is a common type of stroke in children, and infection, cerebral arteriopathy, trauma and moyamoya disease are the most important risk factors. Clinical manifestations can be varied, and the most common ones are paralysis, language disorder and convulsions.
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    Clinical observation of Xiaoer Zhihan Ningshen extract for treating hyperhidrosis children with Qi-Yin deficiency combined with Ying-Wei disharmony syndrome
    WANG Zhang,LIAO Yingzhao.
    2019, 11 (2):  158-160.  doi: 10.3969/j.issn.1674-3865.2019.02.018
    Abstract ( 455 )   PDF (373KB) ( 89 )   Save

    Objective
    To observe therapeutic effects of Xiaoer Zhihan Ningshen extract for treating hyperhidrosis children.
    Methods
    From January 2016 to January 2018, a total of 160 cases of hyperhidrosis children with Qi-Yin deficiency combined with disharmony of Ying-Wei disharmony were randomly divided into the treatment group and the control group,with 80 cases in each group.The treatment group received oral administration of Xiaoer Zhihan Ningshen extract, while the control group was given Yupingfeng granules orally, both twice per day; both groups were treated for 5 days. The overall efficiency and effect on Chinese syndromes was evaluated after treatment and in 1 month after stopping taking the medicine.
    Results
    After 5-day treatment and 1 month after stopping taking medicine, the total effective rate and effect on Chinese syndromes in the treatment group were significantly higher than those of the control group(P<0.05).
    Conclusion
    Xiaoer Zhihan Ningshen extract shows obvious effects in the treatment of hyperhidrosis children with Qi-Yin deficiency combined with Ying-Wei disharmony syndrome.
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    Research of the candidate genes associated with autistic spectrum disorder in children
    XU Jingli,FAN Yanping,GAO Jing
    2019, 11 (2):  161-163.  doi: 10.3969/j.issn.1674-3865.2019.02.019
    Abstract ( 434 )   PDF (331KB) ( 94 )   Save


    Objective
    To explore the difference of gene expression between autistic and normal children.
    Methods
    Totally 30 autistic children in Shenzhen Longgang District Maternal and Child Health Care Hospital from June 2017 to June 2018 were included as the observation group and 20 healthy children as the control group. The blood samples of all subjects were collected and DNA extractions were examined with DNA microarray. The signals were analyzed with copy number.
    Results
    The gene spectrum of 3 SNP locations(re2711888,rs6967728,rs756505) were compared. The results showed that there was no statistical difference in gene expression spectrum between autistic and normal children(P>0.05).
    Conclusion
    There is no notable difference in the expression of 3 candidate genes in autistic children.

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    Clinical study of kinematics analysis method in spastic cerebral palsy
    YANG Yang,LYU Nan,WAN Kai,ZHANG Xiaodong,SHANG Qing
    2019, 11 (2):  163-166.  doi: 10.3969/j.issn.1674-3865.2019.02.020
    Abstract ( 461 )   PDF (463KB) ( 96 )   Save

    Objective
    To explore the application of kinematics analysis method in spastic cerebral palsy.
    Methods
    Sixty cases of spastic cerebral palsy were randomly divided into the control group and the observation group. The control group was treated with Bobath therapy as the main comprehensive rehabilitation method. In the observation group the kinematic analysis method was used to find the sport element for abnormal posture of the child before the intervention, and under its guidance,a rehabilitation program was developed. The GMFM gross motor function scale B area test and Berg balance scale were evaluated before and after the intervention.
    Results
    There was no significant difference in the total score of the Bzone or the total score of the Berg balance scale before intervention between the two groups(P>0.05). The total score of the Bzone and the total score of the Berg balance scale after intervention were significantly higher than those before intervention in the two groups, and the scores of the observation group were significantly higher than those of the control group(P<0.05).
    Conclusion
    The kinematics analysis method can be used to guide the rehabilitation of spastic cerebral palsy and its curative effect is remarkable.
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    Clinical characteristics of Kawasaki disease complicated with liver function damage in children
    LEI Xiaoyu,HE Meiling,SUN Yuchan
    2019, 11 (2):  167-169.  doi: 10.3969/j.issn.1674-3865.2019.02.021
    Abstract ( 578 )   PDF (320KB) ( 116 )   Save

    Objective
    To investigate the clinical characteristics, prognosis and related factors of liver dysfunction in Kawasaki disease in children.
    Methods
    A total of 105 Kawasaki children were included as the research subjects, who were treated in Dalian Children's Hospital from August 2017 to September 2018, and they were divided into two groups: normal liver function group(70 children) and liver dysfunction group(35 children).The two groups were compared in the following aspects: gender age, length of hospital stay, aspartate aminotransferase(AST), alanine aminotransferase(ALT), γ-glutamyl transpeptidase(GGT),total bile acid,serum albumin,total bilirubin,C-reactive protein(CRP),erythrocyte sedimentation rate, WBC count,platelet count,hemoglobin,and the incidence of IVIG no-response.
    Results
    The liver function became normal in 32 children of the liver dysfunction group, and the other 3 had normal liver function at the end of 2 months of follow-up. There was no difference in the length of hospital stay between the two groups(P>0.05). The incidence of IVIG no-response in normal liver function group was 5.7%(4/70), which was significantly lower than that in liver dysfunction group(20.0%,7/35),the difference being statistical(P<0.05).There was no statistical difference in serum albumin, hemoglobin, WBC count or erythrocyte sedimentation rate between the two groups(P>0.05). The AST, GGT, total bile acid, total bilirubin and CRP in liver dysfunction group were significantly higher than those in normal liver function group, while the platelet count was lower, and there was statistical difference(P<0.05).
    Conclusion
    Liver dysfunction is common in children with acute Kawasaki disease, and it is related to IVIG no-response. The liver dysfunction in Kawasaki disease should be paid attention to in order to ensure the proper treatment for the disease.
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    Effects of ambroxol combined with human immunoglobulin on serum electrolytes, B-type natriuretic peptide and neuropeptide Y in the treatment of severe pneumonia in children
    ZHANG Yongchao, GAO Gang
    2019, 11 (2):  170-172.  doi: 10.3969/j.issn.1674-3865.2019.02.022
    Abstract ( 548 )   PDF (327KB) ( 109 )   Save

    Objective
    To observe the effects of ambroxol combined with human immunoglobulin on serum electrolytes concentrations and levels of Btype natriuretic peptide (BNP) and neuropeptide Y (NPY) in children with severe pneumonia.
    Methods
    A total of 86 child patients with severe pneumonia admitted to Luoyang Women and Children Health Care Center were selected for the study and were randomly divided into observation group(n=43) and control group(n=43). Control group was given basic treatments after admission, including pulmonary infection control, respiratory support and acidosis correction, and observation group was given ambroxol hydrochloride injection combined with human immunoglobulin on the basis of treatment for control group, and they were treated for 35d. The efficacy, electrolytes indexes and levels of BNP and NPY were observed in the two groups.
    Results
    The total effective rate of treatment in observation group was significantly higher than that in control group[88.37%(38/43) vs 69.77%(30/43),P<0.05]. After treatment, the levels of blood potassium, blood sodium, blood chlorine and serum calcium in the two groups were significantly increased compared with those before treatment(P<0.05). The above serum electrolytes indexes in observation group after treatment were higher than those in control group (P<0.05). After treatment, the levels of BNP and NPY in the two groups were significantly decreased compared with those before treatment (P<0.05). The levels of BNP and NPY in observation group after treatment were lower than those in control group (P<0.05).
    Conclusion
    Ambroxol combined with human immunoglobulin can improve the symptoms of severe pneumonia and correct electrolyte imbalance of children patients with severe pneumonia, and it has significant effects.
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    Clinical observation on modified Dachaihu decoction in the treatment of acute appendicitis of damp-heat type
    ZHANG Meng,QIN Ye
    2019, 11 (2):  173-176.  doi: 10.3969/j.issn.1674-3865.2019.02.023
    Abstract ( 473 )   PDF (427KB) ( 140 )   Save

    Objective
    To observe the clinical effect of modified Dachaihu decoction combined with routine western medicine in the treatment of dampheat acute appendicitis.
    Methods
    The 40 children with acute appendicitis admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from November 2016 to December 2018 were randomly divided into control group (20 cases) and observation group(20 cases). The control group was told not to take any water, and routine rehydration treatment and antiinfection treatment were given. The observation group was treated with modified Dachaihu decoction on the basis of the treatment for the control group. The clinical efficacy, fever, abdominal pain, Maxwell's point tenderness and relief time of rebound pain, and laboratory indicators (white blood cell count, C-reactive protein) were observed.
    Results
    The total effective rate of the observation group was 95.0%(19/20), which was significantly higher than that of the control group(68.4%,13/20), and the difference was statistically significant(P<0.05). There was no significant difference in antipyretic time between the two groups(P>0.05). The relief time of abdominal pain, tenderness and rebound pain in the observation group was shorter than that in the control group, and the difference was statistically significant(P<0.05). The leucocyte count in the observation group was significantly lower than that in the control group on the 3rd and 7th day of treatment(P<0.05), and the Creactive protein in the observation group was significantly lower than that in the control group on the 7th day of treatment (P<0.05).
    Conclusion
    Modified Dachaihu decoction combined with basic treatment of Western medicine is effective in treating children with appendicitis of damp-heat type.
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    Study on guided education mode in rehabilitation treatment of children with cerebral palsy
    WANG Hongwei
    2019, 11 (2):  176-178.  doi: 10.3969/j.issn.1674-3865.2019.02.024
    Abstract ( 462 )   PDF (351KB) ( 79 )   Save

    Objective
    To analyze the effect of guided education mode in rehabilitation treatment of children with cerebral palsy.
    Methods
    A total of 86 children with cerebral palsy admitted to Tanggangzi Hospital of Anshan from February 2016 to October 2017 were randomly divided into observation group and control group with 43 cases in each group. In the observation group, guided education mode was adopted, while in the control group, basic rehabilitation therapy was carried out; evaluate the curative effect of the two groups. The gross motor function test scale (GMFM), Gesell development score and Barthel index were observed before and after treatment.
    Results
    The disease control rate of the observation group was 93.0%(40/43), which was significantly higher than that of the control group(72.1%,31/43), and the difference was statistically significant(P<0.05). After treatment, the GMFM score, Gesell development score and Barthel index of the two groups were significantly higher than those before treatment, and the indexes of the observation group were significantly higher than those of the control group, the difference being statistically significant(P<0.05).
    Conclusion
    Guided education mode in rehabilitation treatment of children with cerebral palsy is helpful to improve motor function and the treatment results, and promote disease rehabilitation, which is worth learning.
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    Effect of azithromycin combined with montelukast sodium on children with asthmatic bronchitis and its effect on inflammation level
    QU Xin
    2019, 11 (2):  179-181.  doi: 10.3969/j.issn.1674-3865.2019.02.025
    Abstract ( 682 )   PDF (321KB) ( 68 )   Save

    Objective
    To investigate the effect of azithromycin combined with montelukast sodium on children with asthmatic bronchitis and its effect on inflammation level.
    Methods
    Eighty-seven children with asthmatic bronchitis were divided into two groups by random number table method; 43 patients in the single-agent group were given intravenous infusion of azithromycin, and 44 patients in the combination group was treated with montelukast sodium orally in addition to azithromycin. The treatment lasted for one month as a course. Observe the clinical effects in the two groups, including the relief time of cough, fever, wheezing and wheezing rales as well as the length of hospital stay; for inflammation level, detect the level of IL-10, IL-12,ECP and LTE4 in the peripheral blood.
    Results
    The total effective rate of combination group was 93.18%(41/44),significantly  higher than that of the single-agent group(76.74%,33/43),and the difference was statistically significant (P<0.05). The relief time of fever, cough, wheezing and wheezing rales as well as the length of hospital stay was shorter in the combination group than in the single-agent group (P<0.05). After one month of treatment, the level of IL-10, ECP and LTE4 was lower in the combination group than in the single-agent group, while the level of IL-12 was higher(P<0.05).
    Conclusion
    Azithromycin combined with montelukast sodium in children with asthmatic bronchitis can rapidly improve the symptoms, signs and inflammation, and the effect is remarkable.
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    Application of PBL method in child healthcare teaching in higher vocational nursing
    SUN Yanan,XIE Linfeng,LIU Jiali,LUO Meici
    2019, 11 (2):  182-184.  doi: 10.3969/j.issn.1674-3865.2019.02.026
    Abstract ( 401 )   PDF (332KB) ( 70 )   Save

    Objective
    In order to meet the demands for higher vocational nursing talents in the field of modern health of our country, the PBL method was adopted in teaching child health care of community nursing, aiming to explore more suitable methods of teaching higher vocational nursing.
    Methods
    The students of grade 2015 in Sichuan Nursing Vocational College majoring in nursing were included as the study subjects. A total of 123 students of two classes were chosen by cluster randomized sampling, and they were divided into two groups, 62 in control group and 61 in observation group.PBL method was adopted for observation group and traditional teaching method was used in control group. The selfdesigned PBL quality assessment scale for higher vocational nursing was used to evaluate the learning interests, the interpersonal communication ability, teamwork ability and humanistic care ability of the students.
    Results
    The scores of observation group was higher than those of the control group in learning interests, interpersonal communication in nursing and teamwork, and there was statistical difference(P<0.05);there was no statistical difference in the score of humanistic care ability in nursing between the two groups(P>0.05).
    Conclusion
    PBL teaching method improve the quality of students majoring in nursing in higher vocational colleges, and it should be further promoted.
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