Table of Content

25 August 2019, Volume 11 Issue 4 Previous Issue    Next Issue

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Analysis of academic thoughts and clinical experience of Master Wang Lie in preventing and controlling the whole process of children's asthma SUN Liping 2019, 11 (4):  277-279.  doi: 10.3969/j.issn.1674-3865.2019.04.001 Abstract ( 374 )   PDF (394KB) ( 103 )   Save Bronchial asthma is a common respiratory disease in pediatrics. It is clinically characterized by recurrent cough, dyspnea, and wheezing in the throat, which affects children's physical and mental health seriously. The pathogeny of the disease is complicated and it is difficult to heal. There is no exact cure method at present. Professor Wang Lie, a master of Chinese medicine, has been committing to the theoretical and practical research on the prevention and treatment of pediatric diseases. He has many innovations on the basis of inheriting the ancient medical science. He has unique insights into the prevention and treatment of asthma, formulating comprehensive treatment measures, and developing a series of prescriptions. He applies the method of intervention to the whole process of the disease: preventing the disease, preventing its getting more severe, and preventing its recurrence. As a result, a series of treatment schemes have been formed, which has reduced the incidence of the disease and the number of recurrences, and it has been widely used clinically. Related Articles | Metrics

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Professor Yu Jingmao's experience in treating children' s cough with Zhi Sou formula LI Lan, CHEN Hua, YU Jingmao 2019, 11 (4):  279-281.  doi: 10.3969/j.issn.1674-3865.2019.04.002 Abstract ( 420 )   PDF (448KB) ( 140 )   Save Zhi Sou powder, from Yi Xue Xin Wu by Cheng Zhongling, can be used in the treatment of cough(newly-onset or persistent), whether it's caused by internal or external factors. Prof. Yu Jingmao believes that the administration of Zhi Sou powder takes the physiological feature of the lung being tender into account, and the treatment should focus on recovering the pulmonary function by ventilating lung and relieving cough, and moistening lung and removing phlegm. Based on the Zhi Sou powder, almond, Zhi Dong Hua,Zhe Bei and Chuan Bei are added to make the Zhi Sou formula, which is used by differentiation and modification in the clinical treatment of children with cough, and the effect is significant. Related Articles | Metrics

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Analysis of medication rules in the treatment of chronic cough after mycoplasma pneumonia in children by Professor Wang Xuefeng ZHANG Xiuying，WANG Xuefeng，SONG Lichao，ZHANG Lijia，LI Qinghuan 2019, 11 (4):  282-286.  doi: 10.3969/j.issn.1674-3865.2019.04.003 Abstract ( 616 )   PDF (540KB) ( 90 )   Save Objective To investigate the characteristics and rules in the treatment of chronic cough after mycoplasma pneumonia in children by Professor Wang Xuefeng. Methods A total of 277 prescriptions by Professor Wang Xuefeng for the treatment of chronic cough after mycoplasma pneumonia in children were collected and sorted out. The data were analyzed by using SPSS 17.0 software through establishing a systematic database. Results  A total of 84 kinds of traditional Chinese herbs were used in the prescription, and 69 kinds of traditional Chinese herbs with frequency more than 1% were selected for analysis. Among them, the highest frequency of use was 93.50%, the lowest frequency 0.36%.There were 13 kinds of herbs whose frequency was more than 50%. The cold medicines were the most, followed by the warm and placid medicines, and the cool drugs were the least. The drugs were mainly sweet taste medicine, followed by bitter and spicy taste, while the drugs of light, sour, salty, astringent taste were less. The herbs aiming at lung meridian were the most, followed by those aiming at the stomach meridian and heart meridian, and there were herbs aiming at other meridians, such as spleen meridian, large intestine meridian and liver meridian, the liver meridian, the kidney meridian, the gallbladder meridian, the small intestine meridian, the pericardium meridian, the bladder meridian and the triple Jiao meridian. As far as the classification of drug effect was concerned, the drugs with accumulative frequency above 1 000 were phlegm-resolving, cough-relieving and asthma-relieving drugs, followed by heat-clearing and deficiency-tonifying drugs, and then the digestive drugs, astringent drugs, exterior-syndrome relieving drugs, diuresis and dampness-relieving drugs, Liver-calming and wind-quenching drugs, antipsychotic drugs, blood-activating and stasis-removing drugs, Qi-regulating drugs, dampness-removing drugs, purgative drugs and resuscitation drugs for inducing resuscitation. Conclusion Professor Wang Xuefeng's diagnosis and treatment of chronic cough after mycoplasma pneumonia in children is mainly to clear and moist the lung and relieve cough, and the drugs used are mostly slightly cold, sweet and bitter and processed products. Related Articles | Metrics

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Professor Ma Rong's exploration and opinion on external therapy for pediatric epilepsy GAN Lu，MA Rong 2019, 11 (4):  287-290.  doi: 10.3969/j.issn.1674-3865.2019.04.004 Abstract ( 602 )   PDF (627KB) ( 100 )   Save Professor Ma Rong has devoted himself to the treatment of pediatric epilepsy for decades, focusing on digging out other treatments besides oral drugs. He believes that both traditional and modern medicine in the treatment of epilepsy is guided by the purpose of curing or alleviating the symptoms of epilepsy and improving the patients quality of life. The three kinds of treatments recognized in modern medicine are targeted to their suitable population, but they also have the taboos and drawbacks. Traditional medicine is the experience summarized through the practice of countless ancestors in the course of the development of nearly a thousand years. However, because of the limited conditions at that time, there are some deficiencies in collation and clinical research, and some of the effective treatments need further research and development. We should rely on modern advanced technology to further explore its origin and to excavate, which is also a relatively difficult and important research direction at present.  Related Articles | Metrics

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Professor Yu Jianer's experience in treating children with gastroesophageal reflux cough XU Wanchao，YU Jianer，XUE Zheng，ZHANG Xinguang，LI Liqing 2019, 11 (4):  290-292.  doi: 10.3969/j.issn.1674-3865.2019.04.005 Abstract ( 457 )   PDF (462KB) ( 96 )   Save Professor Yu Jianer believes that the main pathogenesis of gastroesophageal reflux cough in children is that the lung and spleen qi are not sufficient, and the viscera is subject to pathogens. Phlegm and indigestion are important pathological factors. Treatment should focus on the regulation combined with lung and spleen, treating the symptoms and causes at the same time. Meanwhile, pay attention to the treatment for airway spasm, protect the spleen and stomach of children, and be careful in using cold medicine and drugs made from metals and stones. A medical record is attached. Related Articles | Metrics

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Professor Zheng Qizhong's experience in treating pediatric refractory epilepsy based on stagnation of phlegm and blood ZHENG Hong, ZHENG Qizhong 2019, 11 (4):  293-295.  doi: 10.3969/j.issn.1674-3865.2019.04.006 Abstract ( 401 )   PDF (464KB) ( 76 )   Save The pediatric refractory epilepsy is one of the difficult miscellaneous diseases characterized by complex pathology and recurrent attacks. This paper summarizes Professor-Zheng Qizhong's experience in treating pediatric refractory epilepsy based on stagnation of phlegm and blood, who considers the combination of stubborn phlegm and blood stasis as an important pathogenic factor. The pathogenesis is formulated as "From phlegm to blood stasis, from blood stasis to phlegm, phlegm and blood stasis are interrelated, and they are each other's cause and effect". So the treatment should be given by syndrome differentiation, including dissolving phlegm and removing blood stasis, which is modified according to the syndrome. Related Articles | Metrics

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Meta-analysis of TCM therapy for children with bronchial asthma at remission stage XU Jing，LI Jianbao，WANG Xia，CHEN Di 2019, 11 (4):  295-300.  doi: 10.3969/j.issn.1674-3865.2019.04.007 Abstract ( 396 )   PDF (2812KB) ( 92 )   Save Objective To systematically evaluate the therapeutic effect and safety of traditional Chinese medicine in the treatment of children with bronchial asthma at remission stage. Methods  We searched CNKI to collect randomized controlled trials(RCTs) on traditional Chinese medicine in the treatment of children with bronchial asthma at remission stage from January to February 2019.Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. After that a Metaanalysis was made by using RevMan 5.3 software. Results  A total of 29 RCTs involving 2 487 patients were included in the study. The Metaanalysis results showed that compared with western medicine, the traditional Chinese medicine could significantly improve the clinical efficiency［OR=3.09,95%CI(2.42,3.94), P<0.000 01］，and the control rate of individual symptom was better than the control group［OR=14.07,95%CI(6.99,28.31)，P<0.000 01］, there being statistically significant differences. Conclusion This study shows that the traditional Chinese medicine is superior to western medicine in overall clinical efficacy. References | Related Articles | Metrics

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Xiyanping injection in the treatment of respiratory syncytial virus pneumonia in children Meta-analysis of effectiveness and safety MA Mingxing,WANG Xuefeng,ZHANG Xiuying,LI Linfeng,JIANG Junshuang,SONG Lichao 2019, 11 (4):  301-307.  doi: 10.3969/j.issn.1674-3865.2019.04.008 Abstract ( 477 )   PDF (4144KB) ( 89 )   Save Objective To systematically evaluate the efficacy and safety of Xiyanping injection in the treatment of respiratory syncytial virus pneumonia in children by meta analysis. Methods The CNKI, VIP, CBM, Wanfang Data, PubMed, Web of Science, EMbase and The Cochrane Library databases were systematically searched, and the search time was until April 30, 2019. Collect randomized controlled trials(RCTs) on Xiyanping injection in the treatment of children with respiratory syncytial virus pneumonia. Two researchers independently completed literature screening, information extraction and risk assessment of bias, and a Metaanalysis was made on the valid data using RevMan 5.3 software. Results A total of 9 clinical controlled studies were included, with a total of 686 cases. Metaanalysis showed that, in terms of effectiveness, Xiyanping injection significantly improved the total effective rate［RR=1.18, 95%CI(1.12, 1.25), P<0.000 01］ and significantly shortened hospital stay［MD=-3.01, 95%CI(-3.82, -2.61), P<0.000 01］; it also shortened the time of fever, and the relief time of cough and lung rales; it accelerated the absorption time of chest inflammation and reduced serum inflammatory factor levels. In terms of safety, the incidence of adverse reactions was reduced［MD=0.45, 95%CI(0.25, 0.82), P<0.010］, and the difference was statistically significant. Conclusion The efficacy and safety of Xiyanping injection in treating children with respiratory syncytial virus pneumonia is better than conventional treatment, which can significantly improve the total clinical effective rate, significantly shorten the hospital stay, improve symptoms and signs, and reduce the incidence of adverse reactions. However, the number and quality of the included literature is limited, and more large-sample, high-quality randomized controlled trials are needed to verify its effectiveness and safety. Related Articles | Metrics

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A survey of external treatment with traditional Chinese medicine for children's cough SONG Yu，LIU Yunjun，ZHUO Yue 2019, 11 (4):  308-311.  doi: 10.3969/j.issn.1674-3865.2019.04.009 Abstract ( 413 )   PDF (623KB) ( 102 )   Save Cough is one of the common lung diseases in pediatrics. At present，the clinical treatment of western medicine is mainly antiinfection and removingphlegm treatment，and the clinical effect is not ideal. TCM external treatment has obvious advantages in treating the disease. In order to provide a useful reference for the clinical treatment of the disease，this paper will review the literature on the treatment for children's cough by external therapy of traditional Chinese medicine in recent years. Related Articles | Metrics

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Clinical observation on the treatment of chronic rhinosinusitis in children by integrated traditional Chinese and western medicine SUN Jiawei，LENG Hui 2019, 11 (4):  311-314.  doi: 10.3969/j.issn.1674-3865.2019.04.010 Abstract ( 334 )   PDF (570KB) ( 60 )   Save Objective To observe the clinical efficacy of Tongqiao decoction combined with Sinupret drops in the treatment of chronic rhinosinusitis with spleen-qi deficiency syndrome in children. Methods Eighty children with chronic rhino sinusitis who were admitted to the Department of Otorhinolaryngology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, from September 2017 to September 2018, were enrolled in the study. They were randomly divided into control group(40 children) and observation group(40 children). The control group was treated with Sinupret drops(Oral) combined with Fluticasone Propionated Nasal Spray for nasal spray. The observation group was treated with Tongqiao decoction(Chinese herbal decoction) on the basis of the treatment for control group. The course of treatment was 1 month. The improvement of the main symptoms and the curative effect of the two groups were observed. The recurrence and adverse reactions were observed during the 3 months of follow-up. Results After 1 month of treatment, the improvement in nasal congestion and runningnose symptoms in the observation group was significantly better than that in the control group, and the difference was statistically significant(P<0.05). There was no significant difference between the two groups in the improvement of headache or hyposmia symptoms(P>0.05). The total effective rate of the observation group was 92.5%(37/40), which was significantly higher than that of the control group(70.0%, 28/40). The difference was statistically significant(P<0.05). After 3 months of follow-up, the recurrence rate of the observation group was 5.0%(2/40), which was significantly lower than that of the control group(22.5%,9/40). The difference was statistically significant (P<0.05). There were no significant adverse reactions during the treatment period in both groups. Conclusion Tongqiao decoction combined with Sinupret drops and Fluticasone Propionated Nasal Spray is better than pure western medicine in treating children with chronic rhinosinusitis with spleen-qi deficiency syndrome. Clinically, this combination of Chinese and western medicine should be actively promoted. Related Articles | Metrics

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Clinical analysis of cytomegalovirus retinitis in infant ZHAO Ailing, DING Daling, WANG Jiangtao, LI Xueqin 2019, 11 (4):  315-317.  doi: 10.3969/j.issn.1674-3865.2019.04.011 Abstract ( 469 )   PDF (405KB) ( 71 )   Save Objective To explore the clinical features, pathogenesis, diagnostic criteria and treatment strategy of cytomegalovirus retinitis(CMVR) in infants. Methods A retrospective analysis was performed based on the clinical data of 11 infants with CMVR having received treatment in our department from August 2015 to June 2018. The clinical features, treatment and prognosis were summarized and analyzed by reviewing the relevant literature. Results Seven infants with CMVR were female and 4 were male, aged 1 month to 8 months; 9 infants with cough or fever as firstonset symptom and 2 with diarrhea as firstonset symptom were hospitalized; serum CMV-DNA of 11 infants and breast milk CMV-DNA 11 breastfed infants were positive. In 11 infants with CMVR 19 eyes had varying degrees of degeneration of retinal spots, which were significantly improved after treatment with ganciclovir, and no obvious complications were observed. Conclusion Cytomegalovirus retinitis is an extremely rare disease with insidious onset and low diagnostic rate in infancy. The disease should arouse adequate awareness, in order to improve the quality of life of children by early diagnosis and treatment. Related Articles | Metrics

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Analysis of the relationship between cardiac vagal tone and school-age developmental outcome in very low birth weight infants ZUO Lei，ZHANG Yingying，ZHAO Jie 2019, 11 (4):  318-321.  doi: 10.3969/j.issn.1674-3865.2019.04.012 Abstract ( 313 )   PDF (414KB) ( 85 )   Save Objective To investigate the correlation between cardiac vagal tone and school-age developmental outcome in very low birth weight infants(VLBWI). Methods This study analyzed 60 VLBWI admitted to our neurological intensive care unit(NICU) from May 2007 to May 2010. The respiratory sinus arrhythmia(RSA) maturity scoring was performed at 33 to 35 weeks of gestational age, and other physiological indicators were recorded, to explore its correlation with the developmental outcome at school age. Results The school-age developmental outcome was closely related to the developmental outcome at 3 years after birth. Multiple regression analysis showed that the VBAWI RSA maturity was related to the social ability at school age. Conclusion RSA measurements can be used to early assess central nervous system self-regulation and predict school-age developmental outcomes. Related Articles | Metrics

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Rule of using traditional Chinese medicine gel in the treatment of epilepsy in children based on traditional Chinese medicine inheritance assistant system JIAO Yang，CHE Wenjin，ZHANG Baoqing 2019, 11 (4):  322-326.  doi: 10.3969/j.issn.1674-3865.2019.04.013 Abstract ( 410 )   PDF (810KB) ( 75 )   Save Objective To analyze and summarize the experience and rule of using traditional Chinese medicine gel in the treatment of epilepsy in children by using traditional Chinese medicine inheritance assistant system, so as to provide reference for clinical treatment of epilepsy in children with the gel. Methods Collect the cases of pediatric epilepsy treated by Prof. Zhang Baoqing with medicinal gel in the Pediatric Outpatient Department of Affiliated Hospital of Shandong University of Traditional Chinese Medicine; input the information of the prescription into the "Traditional Chinese Medicine Inheritance Assistant System". The data mining methods were adopted, such as improved mutual information method, complex system entropy aggregation method and unsupervised entropy hierarchical clustering method, and the rule of the gel prescriptions in the treatment of pediatric epilepsy was analyzed. Results Statistical analysis was conducted in 115 selected gel prescriptions, including 112 kinds of traditional Chinese medicines. The number of times and frequency of drug use in prescriptions were obtained. Fourteen core combinations and seven potential new combinations were discovered through analyzing the association among drugs. Conclusion Nowadays, most of the gel prescriptions for treating epilepsy in children include medicines tonifying deficiency, resolving phlegm, regulating qi and calming liver. The treatment is based on tonifying kidney and calming liver, supplemented by invigorating spleen. The methods of eliminating phlegm and resuscitating Qi, invigorating kidney and tranquilizing liver and calming wind are adopted. Related Articles | Metrics

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Retrospective analysis of 542 children with Henoch-Schonlein purpura SI Xiuying，WANG Hai 2019, 11 (4):  326-329.  doi: 10.3969/j.issn.1674-3865.2019.04.014 Abstract ( 389 )   PDF (549KB) ( 48 )   Save Objective To understand the epidemiological characteristics of Henoch-Schonlein purpura(HSP) in children, observe the prognosis of children with HSP, and analyze the risk factors of long-term urinary abnormalities in children with HSP. Methods Collect and retrospectively analyze the clinical data and feedback of hospitalized children diagnosed with HSP in the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from October 2010 to September 2017. Results Respiratory tract infection is the leading cause of the onset of HSP in children. Skin purpura is the first symptom of HSP in 502/542(92.62%) children, and 15.13%(82/542) hospitalized children had kidney damage; 21.34%(89/417) children had HSP recurrence. The long-term urinary routine was closed related to kidney type of in-hospital diagnosis(OR =4.589, 95%CI 2.357-8.934), children's age at onset being greater than or equal to 6 years old(OR =2.113, 95%CI 1.094-4.079) and recurrent purpura(OR=2.403, 95%CI 1.249-4.622). Conclusion The children with HSP are prone to recurrent skin purpura, and hospitalized children with kidney damage are prone to recurrence(P=0.006<0.05); long-term abnormal routine urine is related to the kidney type of in-hospital diagnosis, onset age ≥6 and recurrent purpura, but is not related to the in-hospital diagnosis of abdominal purpura(P >0.05). Related Articles | Metrics

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Effect of traditional Chinese medicine fumigation combined with wax therapy on the standing balance of spastic cerebral palsy children LIU Xiaoni，LIN Zhuoting，LI Yuxiu，ZHANG Mengtao 2019, 11 (4):  330-332.  doi: 10.3969/j.issn.1674-3865.2019.04.015 Abstract ( 521 )   PDF (388KB) ( 105 )   Save Objective To observe the clinical effect of traditional Chinese medicine fumigation combined with wax therapy on the standing balance of spastic cerebral palsy children. Methods Totally 60 cases of children with spastic cerebral palsy were chosen, who were treated in Foshan Nanhai District Maternal and Child Health Care Hospital from January 2015 to December 2016，and they were divided into control group(30 cases) and observation group(30 cases) according to the order of treatment. Both groups were given routine rehabilitation training, and the observation group was additionally given traditional Chinese medicine fumigation combined with wax treatment, 1 time per day, 6 times per week, with 2 weeks as one course. The interval between each two courses was 1 week. After 3 courses of treatment, the modified Ashworth muscle tension, GMFM(D) and Gait View plantar pressure tester were used to evaluate the muscle tension and standing balance of the child. Results After treatment, the Ashworth muscle tension, GMFM(D) and Gait View plantar pressure test values of both groups were improved to different degrees compared with those before treatment, the difference was statistically significant(P<0.05), and these indexes were better in the observation group(P<0.05). Conclusion Traditional Chinese medicine fumigation combined with wax therapy is a safe and effective anti-spasm treatment. Related Articles | Metrics

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A Meta-analysis of randomized controlled trials of compound Chinese medicine in the treatment of children with Tic disorders JIANG Junshuang，WANG Xuefeng，ZHANG Xiuying，GUAN Huiting 2019, 11 (4):  333-339.  doi: 10.3969/j.issn.1674-3865.2019.04.016 Abstract ( 370 )   PDF (2791KB) ( 123 )   Save Objective To evaluate the efficacy and safety of compound Chinese medicine in the treatment of children with Tic disorders. Methods Randomized controlled trials of compound Chinese medicine in the treatment of children with Tic disorders from January 1，2015 to March 31，2019 were retrieved from PubMed, CNKI, Wanfang and Weipu databases by computer; two researchers screened the papers; ROB bias risk assessment form in RevMan 5.3 software was used to evaluate the quality of included papers and Meta-analysis was performed. Results A total of 29 papers containing 2 370 cases were included in the study. The Meta-analysis showed that the total effective rate of TCM group was higher than that of western medicine group in the treatment of children with Tic disorders［OR=2.23，95%CI(1.73，2.87)，P＜0.000 01］ and the long-term（half a year）efficacy of TCM group was higher than that of western medicine group［OR=4.92，95%CI(3.16，7.66)，P＜0.000 01］，but there was no significant difference in Yale score between the two groups; twenty of them reported side effects. Conclusion According to the studies of randomized controlled trials in the recent four and a half years， compound Chinese medicines have good clinical effects in the treatment of Tic disorders. However， due to the low quality of the papers included in the study and the possibility of publication bias，large sample, multicenter, high-quality randomized controlled trials are still needed to provide clinical basis in order to obtain more reliable and accurate evaluation. Related Articles | Metrics

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Clinical observation on vegetative state of children with craniocerebral injury managed by acupoint electrical stimulation of median nerve ZHANG Ling，DUAN Hualin，QI Daili，LIU Yueyu，HU Li，DENG Ying 2019, 11 (4):  339-342.  doi: 10.3969/j.issn.1674-3865.2019.04.017 Abstract ( 313 )   PDF (581KB) ( 246 )   Save Objective To explore and analyze the vegetative state of children with craniocerebral injury managed by acupoint electrical stimulation of the median nerve. Methods Fifty children at vegetative state due to various causes were chosen, who were treated in Hunan Children's Hospital from Apr. 2013 to Apr. 2017. They were randomly divided into two groups: observation group(25) and control group(25). Both groups received routine comprehensive rehabilitation training. In addition, the observation group was given acupoint electrical stimulation of the median nerve, 30 min at a time, once a day, five days a week, for 6 courses in a row. The Glasgow Coma Measurement Scale(modified) was used to score in both groups. The children's EEG was monitored before and after treatment. Meanwhile, the mean flow velocity of middle cerebral artery(MCA) and basilar artery(BA) was determined by transcranial Doppler in thegroups. Results After treatment, the improvement in the EEG of observation group was better than that of control group(P<0.05). The Glasgow score was higher in both groups after treatment, and it was even higher in observation group than in control group(P<0.05). The mean flow velocity of the two kinds of arteries was significantly higher after treatment than before treatment in both groups, and it was higher in observation group than in control group(P<0.05). Conclusion The acupoint electrical stimulation of median nerve on the basis of routine treatment can play an effective role in promoting the arousal of the patients, which is beneficial to the rehabilitation and prognosis of children at vegetative state. Related Articles | Metrics

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Clinical effect of early acupuncture to promote awakening combined with comprehensive rehabilitation on children with severe craniocerebral trauma HE Jinhua，YUAN Liping，QIN Rong,LIU Hua，ZHOU Hongtao 2019, 11 (4):  343-347.  doi: 10.3969/j.issn.1674-3865.2019.04.018 Abstract ( 401 )   PDF (581KB) ( 65 )   Save Objective To observe the clinical effect of early acupuncture to promote awakening combined with comprehensive rehabilitation intervention on children with severe craniocerebral trauma. Methods nTotally 48 children with severe craniocerebral injury who were treated from January 2013 to August 2018 in our hospital were chosen. They were divided into two groups according to whether or not early acupuncture was used to promote awakening. The observation group was treated with early interventional acupuncture and comprehensive rehabilitation(n=28), while the control group only received comprehensive rehabilitation and was not treated with acupuncture and moxibustion(n=20). After 3 months of treatment, the rate of disturbance of consciousness， recovery of disturbance of consciousness， clinical efficacy and daily living ability of children were compared between the two groups. Results The GCS scores of the observation group were significantly higher than those of control group at 1 month,2 months and 3 months after treatment, respectively, and the difference was statistically significant(P<0.05). The repeated measurement variance analysis showed that there was statistical difference in the time effect and interaction effect(P<0.05),indicating that GCS scores of the two groups had an upward tendency, and the significance of difference in GCS scores between the two groups might be related to the time point of observation(P<0.05).After 3 months of treatment, the rate of conscious awareness of observation group was significantly higher than that of the control group, while the duration of disturbance of consciousness was significantly shorter, and there was statistical difference(P<0.05). The Barthel index in daily living ability of children over 3 years old in observation group was significantly higher than that in control group(P<0.05). At 3 months after treatment, the clinical total effective rate of observation group was 89.2%(25/28), significantly higher than the control group(65.0%,13/20)(P<0.05). Conclusion Early acupuncture to promote awakening combined with comprehensive rehabilitation therapy can significantly shorten the time of consciousness disturbance of severe craniocerebral trauma， promote the improvement of daily living ability of severe craniocerebral trauma， and improve the recovery of cognition and motor abilities. Related Articles | Metrics

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Clinical observation of Qingfei Huayu decoction assisting the treatment of children with large lobar pneumonia CHU Yubo，HOU Yuling 2019, 11 (4):  347-350.  doi: 10.3969/j.issn.1674-3865.2019.04.019 Abstract ( 459 )   PDF (541KB) ( 103 )   Save Objective To investigate and analyze the clinical efficacy of integrated Chinese and western medicine in the treatment of children with large lobar pneumonia. Methods A total of 95 children with lobar pneumonia admitted to our hospital from January 2017 to January 2019 were randomly divided into two groups. Fortyeight patients in the treatment group were given the selfmade prescription of Qingfei Huayu decoction combined with azithromycin. In the control group, 47 patients received azithromycin. The treatment lasted for 10 days. The clinical efficacy, time for symptoms and signs to disappear, lung function index, and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 95.8%（46/47）, which was significantly higher than that of the control group(80.9%,38/47). The difference was statistically significant(P<0.05).Compared with the control group, the duration of fever, the duration of cough, the recovery time of lung rales, and the time for imaging signs to return to normal were shorter in the observation group. The difference was statistically significant(P<0.05). The Vt/kg, TPTEF/TE and VTEEF/VE levels of both groups were significantly higher after treatment than before treatment, and these indexes in observation group were significantly higher, the difference being of statistical significance(P<0.05).The incidence of adverse reactions was significantly lower in the observation group than in the control group, and the difference was statistically significant(P<0.05). Conclusion The clinical efficacy of integrated Chinese and western medicine has good clinical effect in the treatment of children with large lobar pneumonia, which can speed up the disappearance of symptoms and has high safety. Related Articles | Metrics

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An investigation of vitamin A and E levels in serum of children with mycoplasma pneumoniae pneumonia XU Ying, SU Yanqi, LANG Huili 2019, 11 (4):  351-353.  doi: 10.3969/j.issn.1674-3865.2019.04.020 Abstract ( 385 )   PDF (316KB) ( 75 )   Save Objective To analyze vitamin A and E levels in serum of children with mycoplasma pneumoniae pneumonia, and to study the relationship between the change in vitamin A and E levels and Mycoplasma pneumoniae pneumonia in children. Methods Totally 90 children with mycoplasma pneumoniae pneumonia treated in our hospital in 2018 were selected as observation group, and 90 healthy children for checkup in the same period were selected as control group. The serum levels of vitamin A and E were compared between the two groups. Results The serum level of vitamin A in observation group was much lower than that of control group; the difference was statistically significant(P<0.05). There was no statistical difference in serum vitamin E levels between the two groups(P>0.05). The prevalence of suspicious subclinical vitamin A deficiency in observation group was 38.89% and the prevalence of subclinical vitamin A deficiency in observation group was 34.44%, both of which were higher than those of control group with statistical difference(P<0.05). Conclusion The suspicious subclinical vitamin A deficiency and subclinical vitamin A deficiency commonly exist in the children with mycoplasma pneumoniae pneumonia. There maybe a correlation between vitamin A deficiency and mycoplasma pneumoniae pneumonia. Related Articles | Metrics

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Effect of Helicobacter pylori infection on renal function in children with Henoch-Schonlein purpura HE Jiao 2019, 11 (4):  353-355.  doi: 10.3969/j.issn.1674-3865.2019.04.021 Abstract ( 425 )   PDF (375KB) ( 69 )   Save Objective To investigate the effect of Helicobacter pylori infection on renal function in children with Henoch-Schonlein purpura. Methods A total of 218 children with Henoch-Schonlein purpura admitted to Shenyang Children's Hospital from January 2016 to January 2018 were selected and divided into infection group(68 patients) and non-infection group(150 patients) according to whether they were infected with Helicobacter pylori. Helicobacter pylori eradication was performed in children of the infection group. The incidence of renal function injury and the rate of renal function improvement were compared between the two groups. Results The incidence of renal function injury in the infection group was 58.9%(40/68), which was significantly higher than that in the non-infection group［(34.7%(52/150)］, and the difference was statistically significant(P<0.05). In the infection group, there were 40 cases of renal damage, and 30 cases were turned negative after treatment, while 10 cases were not turned negative. The renal function improvement rate in negative children was 86.7% (26/30), which was significantly higher than that of 50.0%(5/10) in the children who were not turned negative, and the difference was statistically significant(P<0.05). Conclusion The renal function of children with Henoch-Schonlein purpura may be damaged to some extent after the infection of helicobacter pylori. After being treated in time, the damage can be improved and gradually the children can have normal renal function. Related Articles | Metrics

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Effect analysis of modified Zhibai Dihuang pill on children with idiopathic precocious puberty ZHANG Suihong 2019, 11 (4):  356-358.  doi: 10.3969/j.issn.1674-3865.2019.04.022 Abstract ( 522 )   PDF (333KB) ( 159 )   Save Objective To explore the therapeutic effect of modified Zhibai Dihuang pill in treating children with idiopathic precocious puberty. Methods Totally 200 cases of children with idiopathic precocious puberty admitted to Puning Overseas Chinese Hospital from November 2016 to December 2018 were selected as research subjects and were randomly divided into control group and observation group, 100 cases in each group. Control group was given triptorelin, while observation group was given modified Zhibai Dihuang pill. The height, the ratio of bone age with age(BA/CA), nucleus diameter of left breast, nuclear diameter of right breast and follicle diameter, serum levels of folliclestimulating hormone(FSH), estradiol(E2) and serum luteinizing hormone(LH), and serum levels of insulinlike growth factor 1(IGF-1) were compared between the two groups before and after treatment. Results There was no significant difference in height or BA/CA between the two groups after treatment compared with before treatment(P>0.05). After treatment, the diameter of left and right breast nucleus and follicle in the observation group were significantly smaller than those in the control group, with statistically significant differences(P<0.05). After treatment, the levels of FSH, E2 and LH in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05). There was no statistically significant difference in IGF-1 levels between the two groups(P>0.05). Conclusion Modified Zhibai Dihuang pill has significant effect on children with idiopathic precocious puberty, and can effectively improve the symptoms of children and reduce the level of sex hormones.  Related Articles | Metrics

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Treatment for Yang deficiency and phlegm obstruction in convalescent stage of pediatric pneumonia with Wenyang Huayin method ZHAO Huiying,SONG Guihua 2019, 11 (4):  359-361.  doi: 10.3969/j.issn.1674-3865.2019.04.023 Abstract ( 408 )   PDF (481KB) ( 78 )   Save In the recovery period of pediatric pneumonia , most children have no acute symptoms such as fever or dyspnea, but often have coughs with sputum, phlegm sounds in the throat, and long time of lung rales. In severe cases, even wheezing occurs repeatedly. This period lasts for a long time, and is often prolonged and lingering.  Its pathogenesis is complex, that is, deficiency of Yang is the root cause while phlegm in the lung is the superficial cause. Therefore, in the treatment，the Chinese herbs of warming Yang are used to solve the fundamental problem while Chinese herbs to resolve phlegm are uses to treat the superficial cause. Related Articles | Metrics

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Study on the effect of diversified nursing methods in children with bronchial asthma and its influence on pulmonary function FAN Guilin，BAI Fang，DENG Chao 2019, 11 (4):  362-364.  doi: 10.3969/j.issn.1674-3865.2019.04.024 Abstract ( 312 )   PDF (367KB) ( 88 )   Save Objective To explore the clinical effect of diversified nursing methods in children with bronchial asthma and its influence on pulmonary function. Methods From March 2017 to October 2018, 82 children with bronchial asthma in Pediatric Department of our hospital were selected for study. According to the order of admission, the children were divided into control group and observation group with 41 cases in each group. The control group was given routine nursing, while the observation group was given diversified nursing. The improvement in pulmonary function and nursing satisfaction were observed and compared between the two groups. Results The pulmonary function in the observation group was significantly improved. The maximum expiratory flow(PEF), forced expiratory volume(FEV1) and forced vital capacity(PVC) in the observation group were significantly higher than those in the control group(P<0.05).The nursing satisfaction rate of the family members of the observation group was 95.12% (39/41), which was significantly higher than that of the control group (78.05%,32/41), and the difference was statistically significant (P<0.05). Conclusion Diversified nursing has better effect on children with bronchial asthma. It can promote the improvement of pulmonary function, alleviate discomfort and improve nursing satisfaction. It is worth promoting. Related Articles | Metrics

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Value of individualized continuous nursing model in clinical treatment of children with cerebral palsy HONG Li，SHANG Qing，WU Yingying，GE Xuejiao，WANG Yanan 2019, 11 (4):  365-368.  doi: 10.3969/j.issn.1674-3865.2019.04.025 Abstract ( 288 )   PDF (420KB) ( 57 )   Save Objective To explore the application value of individualized continuing nursing model in the clinical treatment of children with cerebral palsy. Methods Totally 60 cases of children with cerebral palsy admitted to our hospital from January 2017 to October 2018 were selected as the research subjects. They were divided into control group and observation group according to random number table method, 30 cases in each group. The control group was given routine nursing, while the observation group was given individualized continuous nursing. The rehabilitation effect, gait index, limb motor function score and balance function score of the two groups were compared, and the negative emotional score and nursing satisfaction of the family members of the two groups were compared. Results The total effective rate of rehabilitation in the observation group was 93.3% (28/30), which was significantly higher than 73.3% (22/30) in the control group, and the difference was statistically significant (P<0.05). The fastest walking speed and stride length of 10 m after nursing in the observation group were higher than those in the control group, and the difference in stride length between the sickened and the healthy side was smaller than that in the control group (P<0.05). The scores of limb motor function and balance function in the observation group were higher than those in the control group (P<0.05). The scores of SAS and SDS in the observation group were lower than those in the control group (P<0.05). The total satisfaction rate of the family members in the observation group was 96.7% (29/30), which was significantly higher than 80.0% (24/30) in the control group , and the difference was statistically significant (P<0.05). Conclusion Individualized continuing nursing model can effectively improve the rehabilitation effect of children with cerebral palsy, improve their gait, limb movement function and balance function, reduce the negative emotions of their families, and improve their nursing satisfaction. Related Articles | Metrics