Table of Content

01 November 2019, Volume 11 Issue 5 Previous Issue    Next Issue

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Effect of traditional Chinese medicine soaking combined with rehabilitation training in the treatment of spastic cerebral palsy ZHANG Yan，HUANG Lihua，SHI Yun, LIU Fang，ZHANG Wenliu，LEI Yanbo 2019, 11 (5):  369-372.  doi: 10.3969/j.issn.1674-3865.2019.05.001 Abstract ( 622 )   PDF (444KB) ( 91 )   Save Objective To observe the effect of traditional Chinese medicine spasmolysis formula combined with modern rehabilitation training on spasmodic cerebral palsy (referred to as cerebral palsy). Methods Totally 60 children with spastic cerebral palsy admitted to liuzhou traditional Chinese medicine hospital from August 2016 to May 2019 were selected as the study subjects, and were randomly divided into the observation group and the control group with 30 cases each. In the control group, Bobath therapy was adopted as the main exercise therapy for rehabilitation training. In the observation group, on the basis of treatment for the control group, traditional Chinese medicine spasmolysis prescription was applied for bathing. The modified Ashworth scale (MAS) score was used to evaluate the clinical efficacy, and the gross motor function test (GMFM) was used to evaluate gross motor function. Results The total effective rate of the observation group was 100.0% (30/30), which was significantly higher than that of the control group (80.0% (24/30), and the difference was statistically significant (P<0.05). GMFM score of the two groups after treatment was significantly higher than that before treatment, and the difference was statistically significant (P<0.05). There was no significant difference in GMFM score between the two groups after treatment (P>0.05). Conclusion The spasmolysis prescription for bathing combined with rehabilitation training can obviously improve the muscle tension of children with spasmodic cerebral palsy, which is beneficial to the training of gross motor function. Related Articles | Metrics

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Effect of core stability training on motor function and walking ability in children with spastic cerebral palsy SHANG Peimin，LI Yanping 2019, 11 (5):  372-375.  doi: 10.3969/j.issn.1674-3865.2019.05.002 Abstract ( 641 )   PDF (483KB) ( 81 )   Save Objective To analyze the effect of core stability training on children with spastic cerebral palsy and to explore the effect of this training on the fine and gross motor function of the children. Methods A total of 103 children with spastic cerebral palsy admitted to our hospital from Apr. 2017 to Apr. 2019 were enrolled. The children were divided into study group and control group according to the time of admission. The control group(n=51) received routine rehabilitation treatment including Rood therapy and Bobath therapy (the neurodevelopmental therapy and active and passive exercise training); the study group(n=52) were given additional core stability training; both groups were treated for 2 months. After the end of the treatment, the two groups were compared in the improvement of fine motor function, gross motor function, balance ability, walking ability and functional independence. Results The scores of PDMS FM scale and visualmotor integration scores of the study group were higher than those of the control group (P<0.05). The GMFM, BBS and WeeFIM scores of the study group were higher than those of the control group (P<0.05). The 10MWT results of the study group showed that the time and number of steps required for 10 m were lower than those of the control group (P<0.05). Conclusion Core stability training can improve the fine and gross motor function of children with spastic cerebral palsy, improve walking ability and increase functional independence.  Related Articles | Metrics

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Analysis of high risk factors and brain magnetic resonance features in children with cerebral palsy 2019, 11 (5):  376-378.  doi: 10.3969/j.issn.1674-3865.2019.05.003 Abstract ( 471 )   PDF (373KB) ( 68 )   Save Objective To analyze the high risk factors of cerebral palsy in order to provide evidence for prevention and early intervention of cerebral palsy. Methods Totally 208 children with cerebral palsy, who were treated in our hospital from January 2016 to December 2018, were analyzed based on the high risk factors of cerebral palsy during pregnancy and childbirth and the results of magnetic resonance imaging (MRI). The characteristics of MRI findings and high risk factors were analyzed. Results The high risk factors were in turn preterm birth, low birth weight, hypoxicischemic encephalopathy, twins, neonatal bilirubin encephalopathy, intracranial hemorrhage, fetal preservation, old mothers, test tube infants, and pregnancyinduced hypertension during pregnancy. Brain MRI is more likely to show paraventricular leukomalacia in premature infants, and encephalomalacia, congenital cerebral malformations and brain dysplasia in fullterm infants, the difference being statistically significant(P<0.05). Conclusion The intervention measures should be formulated according to the high risk factors of cerebral palsy to prevent the occurrence of cerebral palsy. Related Articles | Metrics

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Clinical observation on acupuncture combined with exercise therapy in the treatment of spastic sputum cerebral palsy LI Kewei 2019, 11 (5):  379-381.  doi: 10.3969/j.issn.1674-3865.2019.05.004 Abstract ( 450 )   PDF (374KB) ( 80 )   Save Objective To investigate the effect of acupuncture combined with exercise therapy on children with spastic sputum cerebral palsy (referred to as cerebral palsy). Methods Sixty children with spastic sputum cerebral palsy treated in our hospital from October 2016 to October 2018 were selected and were randomly divided into observation group(30 children) and control group(30 children). The control group was given exercise rehabilitation, including exercise therapy, occupational therapy, and core stability training. The observation group received acupuncture treatment in addition to the treatment for the control group. The course of treatment was 12 weeks. The modified Ashworth scale and the dorsal dorsiflexion angle were used to evaluate the relief of the muscle tension of the lower extremity gastrocnemius in the two groups. The changes of the D and E regions of the gross motor function measurement (GMFM) were used to evaluate the improvement in standing, walking and running functions. The improvement in daily living ability was assessed using the Activity of Daily Living (ADL) scale. Results The score of the modified Ashworth scale was lower in the observation group than in the control group, while the angle of the dorsiflexion of the foot was higher(P<0.05). The D, E and ADL scores of GMFM in the observation group were higher than those in the control group, and the difference was statistically significant(P<0.05). Conclusion Acupuncture combined with exercise therapy for children with spastic sputum cerebral palsy can achieve satisfactory results. Related Articles | Metrics

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Systematic evaluation of inflammatory model of mice infected by influenza virus in haze environment MIN Na, WU Zhenqi, LIU Guanghua 2019, 11 (5):  382-386.  doi: 10.3969/j.issn.1674-3865.2019.05.005 Abstract ( 610 )   PDF (636KB) ( 91 )   Save Objective To establish a mouse model of influenza virus(IV) infection in haze environment, and to investigate its effect on the expression of tumor necrosis factor-α(TNF-α) in serum, airway secretory immunoglobulin A(sIgA) in nasopharyngeal lavage fluid and pulmonary surfactant-associated protein A(SP-A) in lung tissue of mice. Methods Seventy-two SPF grade BABL/c mice were randomly divided into the normal group (group A),PM2.5 tracheal drip group (group B),IV infection group(group C) and -PM2.5- tracheal drip+IV infection group(group D), with 18 rats in each group. Except the group A, the other groups of mice were treated with PM2.5 tracheal drip/IV infection model, and samples were obtained on the day of 3, 7, 10 after the model was established. The lung tissue sections were examined by histopathology; the serum levels of TNF-α and the nasopharyngeal lavage fluid sIgA in the mice were assessed by enzyme-linked immunosorbent assay(ELISA);the expression of SP-A protein in lung tissue of mice was detected by immunohistochemical SP method and Western-blot method. Results After double infection with PM2.5 and IV in mice, the pathological examination revealed thickening of alveolar septum and bronchioles, and extensive inflammatory cell infiltration in the lung tissues; the expression of TNF-α in serum of mice was significantly up-regulated; the content of sIgA in nasopharyngeal lavage fluid and the expression of SP-A in lungs of mice decreased. Compared with group B, group C could decrease the expression of sIgA in nasopharyngeal lavage fluid and SP-A in lung, and there was no significant difference at each time point(P>0.05);the expression of sIgA and SP-A was significantly decreased in group D on day 3 and 7(P<0.05),and it began to rise gradually on the tenth day. Conclusion In this experiment, all three methods of modeling have caused lung injury in varying degrees; especially, the lung injury caused by PM2.5 tracheal drip and IV infection is the most serious. Therefore, it is proved that this method is simple and reliable, which is helpful for further study of pulmonary diseases and inflammation mechanism. Related Articles | Metrics

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Application value of chromosome microarray chip analysis in children with psychomotor retardation XIE Qiaoling,YE Yanxia,LI Yanxia,LIANG Fujian,YANG Junxiu, XIN Jing 2019, 11 (5):  387-391.  doi: 10.3969/j.issn.1674-3865.2019.05.006 Abstract ( 597 )   PDF (608KB) ( 99 )   Save Objective Chromosome microarray chip analysis technology is used to detect copy number variations(CNVs) in 150 children with psychomotor retardation of unknown causes, and to investigate the genetic causes. Methods The Affymetrix Cytoscan 750K chip was used for genomic analysis in 150 children with psychomotor retardation who were treated from January 2015 to June 2019 in our department. Results CNVs- related to MR/DD was detected in 25 cases, with a detection rate of 16.7%. Among them, 10 were known syndromes, 2 were microdeletions, 1 was large fragment deletions, 7 were clinically pathogenic copy number changes, and 5 were clinically unknown. Conclusion Chromosome microarray chip analysis technology can increase the level of molecular etiology diagnosis in children with psychomotor retardation of unknown causes, and is of great significance to further study of pathogenetic mechanism, which provides guidance for evaluating prognosis and family recurrence risk as well as making rehabilitation decisions. Related Articles | Metrics

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Study on the effect of life skill training on daily living ability of children with mental retardation WANG Yanan，SHANG Qing，WU Yingying，LI Qian，WANG Tingting，LI Haijuan 2019, 11 (5):  391-393.  doi: 10.3969/j.issn.1674-3865.2019.05.007 Abstract ( 561 )   PDF (387KB) ( 72 )   Save Objective To analyze the application value of life skill training in optimizing the daily living ability of children with mental retardation. Methods A total of 60 children with mental retardation admitted to Zhengzhou Children's Hospital from January 2016 to January 2019 were selected and randomly divided into control group and observation group according to the order of admission,30 children in each group. The control group was given routine nursing care(such as dietary intervention, medication guidance, health education, etc.), and the observation group was given life skill training in addition to routine nursing care. The ADL scores and social adaptability scores of the two groups of children, as well as the family members' recognition of clinical nursing work were compared. Results The ADL score of the observation group was (24.22±4.13), significantly lower than that of the control group (34.25±5.67), and the difference was statistically significant (P<0.05). The social adaptability scores (including independent living, social communication, exercise and selfmanagement) of the observation group were significantly better than those of the control group, with statistically significant differences(P<0.05). Family members of children in the observation group had a recognition of clinical nursing work at 93.33%(28/30), which was significantly higher than that of the control group(73.33%,22/30), and the difference was statistically significant(P<0.05). Conclusion On the basis of routine nursing care, life skill training for children with mental retardation can not only effectively strengthen the children's daily living ability and social adaptability, but also further improve the family's recognition of clinical nursing work, which is worthy of reference and promotion. Related Articles | Metrics

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Method of reinforcing earth to generate metal for asthma in remission in children: a systematic review and Meta-analysis LI Lixiang, ZHANG Renpan, ZHANG Jingrong, CHEN Siwen 2019, 11 (5):  394-400.  doi: 10.3969/j.issn.1674-3865.2019.05.008 Abstract ( 757 )   PDF (2132KB) ( 92 )   Save Objective To systematically assess the effectiveness of the Method of Reinforcing Earth to Generate Metal (MREGM) for the treatment of asthma in remission in children. Methods Some databases including CNKI, Wanfang, CMB, PubMed and Cochrane were searched by two independent researchers for the related clinical randomized controlled trials(RCTs) about the MREGM and western medicines for treating asthma in remission. The search time was from the inception of the databases to January 1st, 2019. Metaanalysis was performed to analyze all the included data by using Review Manager 5.3. Results A total of 21 RCTs involving 1 483 patients were included in this meta-analysis. The results demonstrated that MREGM had better effects in increasing the total effective rates［RR=1.25, 95%CI(1.17, 1.32), P＜0.000 01］, decreasing the number of asthmatic attack［WMD = -0.65, 95%CI(-0.83, -0.46),P＜0.000 01］ ,increasing the TCM syndrome scores［SMD =-1.44, 95%CI(-1.81, -1.07),P＜0.000 01］, and improving pulmonary function and biochemical indexes than western medicine. Conclusion MREGM is more effective than western medicine in the treatment of childhood asthma in remission(lung-and-spleen-qi deficiency syndrome). However, due to the low quality of the trials included in this study, more high-quality RCTs are needed to further verify this conclusion. Related Articles | Metrics

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Correlation between the level of serum C-reactive protein as well as total IgE and the severity of acute asthma attack in children CHEN Yanying，LUO Lan，LONG Caixia 2019, 11 (5):  400-403.  doi: 10.3969/j.issn.1674-3865.2019.05.009 Abstract ( 456 )   PDF (518KB) ( 93 )   Save Objective To investigate the correlation between the level of serum CRP as well as total IgE and the severity of asthma in children with acute asthma attack. Methods A total of 102 cases of children with bronchial asthma who were admitted to emergency center of our hospital from January 2017 to December 2018 were selected as research subjects. According to the severity of asthma, they were divided into 34 cases in mild group, 39 cases in moderate group and 29 cases in severe group. During the same period, 30 healthy children were selected as the control group. Serum CRP, total IgE levels and forced expiratory volume/forced vital capacity (FEVl %) in each group were measured, and the correlation between serum CRP as well as total IgE levels and severity of asthma in children was analyzed. Results Serum CRP levels in the mild, moderate and severe groups were (7.36±1.98), (9.02±2.05) and (11.37±2.14) mg/L, respectively, significantly higher than those in the control group (1.02±0.67) mg/L, 〖JP2〗with statistically significant differences (P<0.05). The total IgE levels of the mild, moderate and severe groups were (269.37±65.38), (347.15±72.02) and (429.41±69.71) IU/mL, respectively, significantly higher than those of the control group (81.53±23.03), with statistically significant differences (P<0.05). The levels of FEV1% in the mild, moderate and severe groups were 65.33%, 51.36% and 38.21%, respectively, all of which were significantly lower than those in the control group(83.00%), with statistically significant differences (P<0.05). Pearson correlation analysis showed that serum CRP and total IgE levels were negatively correlated with FEVl % in children with acute asthma attacks (r=-0.527, -0.481, P<0.05). Conclusion Serum CRP and total IgE levels are negatively correlated with the severity of acute asthma attack in children with acute asthma attack. The detection of serum CRP and IgE levels in children with acute asthma attack is helpful to early and timely judge the severity of acute asthma attack, which is of great significance for the diagnosis and treatment of the disease. Related Articles | Metrics

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Clinical study of S100B and NSE in children with Mycoplasma pneumoniae pneumoniacomplicated with central nervous system damage RUAN Yucai，XIAO Xiaobing，CHEN Shaoling，DENG Jianrong，YANG Zhi 2019, 11 (5):  404-407.  doi: 10.3969/j.issn.1674-3865.2019.05.010 Abstract ( 579 )   PDF (514KB) ( 191 )   Save Objective To study the level of S100B and NSE in cerebrospinal fluid of pneumonia mycoplasma pneumonia（MPP）complicated with central nervous system damage in children. Methods Totally 35 cases of MPP complicated with central nervous system damage were chosen as observation group, and 40 MPP children were included as control group; all the children were treated in Pediatric Department of Yuebei People's Hospital in Shaoguan from Jan. 2017 to Feb. 2019. The clinical manifestations on admission and the related auxiliary examinations were compared between the two groups. Examination of S100B and NSE in cerebral fluid was completed within 3 days of admission in MPP children with central nervous system damage at acute stage, and re-examination was carried out after 2 weeks of treatment. Based on the prognosis, the difference in S100B and NSE in cerebral fluid before and after treatment was compared between the cured children and the uncured children. Results In the observation group, there were 26 cases (74.3%) of high fever, whose incidence was significantly higher than that in control group (47.5%, 19 cases) (P<0.05). There were 35 cases (100%) of elevated C-reactive protein in observation group, significantly more than those in control group (28 cases, 70.0%) (P<0.05). After 14 days of treatment, 28 children (80.0%) were cured, while 7 (20.0%) still had obvious nervous symptoms, including 5 cases of disturbance of consciousness and 2 cases of abnormality in mental behavior and intelligence. There was no difference in NSE within 3 days of admission at acute stage between the cured children and uncured children (P<0.05). After 14 days of treatment, the NSE in uncured children was significantly higher than that in cured children (P<0.05); S100B in uncured children was significantly higher than that in cured children both within 3 days of admission at acute stage and at 14 days after treatment (P<0.05). Conclusion The content of NSE and S100B in cerebral fluid is related to the disease severity of MPP children with central nervous system damage, and S100B is obviously abnormal at the early stage. Related Articles | Metrics

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Meta-analysis of the efficacy of traditional Chinese medicine combined with cyclophosphamide in the treatment of refractory nephrotic syndrome in children MA Mingxing, WANG Xuefeng,SHAN Hongmei，ZHANG Xiuying, LI Linfeng, WANG Yawen 2019, 11 (5):  408-414.  doi: 10.3969/j.issn.1674-3865.2019.05.011 Abstract ( 680 )   PDF (3152KB) ( 70 )   Save Objective To systematically evaluate the efficacy of traditional Chinese medicine combined with cyclophosphamide in the treatment of refractory nephrotic syndrome in children, and provide evidence-based evidence for clinical application. Methods Retrieve systematically the CNKI, Wanfang Data, VIP, CBM, PubMed, EMbase and The Cochrane Library databases. The publication time was from the inception of the database to June 1st, 2019.According to the inclusion and exclusion criteria, a randomized controlled trial of Chinese medicine combined with cyclophosphamide in the treatment of children with refractory nephrotic syndrome was selected. The relevant data were recorded. The quality of the literature was evaluated by the standard developed by the Cochrane Collaboration. Meta analysis was performed by RevMan5.3 software. Results A total of 10 studies involving 758 children were included.Metaanalysis showed that the combination of traditional Chinese medicine with cyclophosphamide significantly increased the total effective rate compared with the control group［RR=1.16, 95%CI(1.10, 1.23), P<0.000 01］, increased the total cure rate［RR=1.33 95%CI(1.15, 1.55), P=0.000 2］,and reduced recurrence rate［RR=0.31, 95%CI(0.20, 0.47), P<0.000 01］. At the same time, serum albumin was significantly increased［RR=6.28, 95%CI(4.20, 8.36), P<0.000 01］, 24 h urine protein quantitation was significantly reduced RR=-1.05, 95%CI(-1.45, -0.64) ),P<0.000 01］, and the total cholesterol was also significantly decreased［RR= - 1.80, 95%CI(-2.46, - 1.15),P<0.000 01］. Conclusion Traditional Chinese medicine combined with cyclophosphamide is effective in the treatment of refractory nephrotic syndrome in children. It can increase the total effective rate and total cure rate, reduce the recurrence rate, and greatly improve the quality of life of children. However, the quality of the literature included in this study is low, and the above conclusions still need to be verified by more high-quality clinical trials. Related Articles | Metrics

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Efficacy of Bufei Yiqi decoction in adjuvant therapy for child patients with bronchial asthma and its influence on the levels of inflammatory factors LI Zhe, YANG Hong, XU Rongyan, LIU Ping, SHI Yan, ZHANG Yitang 2019, 11 (5):  415-418.  doi: 10.3969/j.issn.1674-3865.2019.05.012 Abstract ( 816 )   PDF (488KB) ( 105 )   Save Objective To explore the effects of Bufei Yiqi decoction in adjuvant therapy for child patients with bronchial asthma and its influence on levels of inflammatory factors. -Methods Totally 128 child patients with mild-to-moderate bronchial asthma who were treated in Nanyang Central Hospital from -January- 2018 to December 2018 were selected as study subjects and were randomly divided into observation group(64 cases) and control group(64 cases). Both groups were given budesonide and other antitussive and antiasthmatic, bronchus-dilating and anti-infective symptomatic supportive treatment, and observation group was also given modified Bufei Yiqi decoction. The clinical efficacy in the two groups was compared. The changes in lung function indexes (total airway resistance, central airway resistance, peripheral airway resistance) and levels of serum inflammatory factors ［C-reactive protein(CRP), eosinophil(EOS), interleukin-4(IL-4), interleukin-10(IL-10)］ were observed in the two groups before treatment and after 1 week of treatment. Results After 1 month of treatment, the total clinical effective rate in observation group was significantly higher than that in control group［96.8%(62/64) vs.87.5%(54/64)］(P<0.05). After 1 month of treatment, the central airway resistance and total airway resistance in the the two groups were significantly lower than those before treatment, while the peripheral airway resistance was higher; the central airway resistance and total airway resistance in observation group were significantly lower than those in control group, while the peripheral airway resistance was significantly higher(P<0.05). After 1 month of treatment, the levels of CRP, EOS and IL-4 in the two groups were significantly lower than those before treatment, while the IL-10 level was significantly higher(P<0.05). The levels of CRP, EOS and IL-4 in observation group were significantly lower in observation group than those in control group, while the IL-10 level was significantly higher(P<0.05). Conclusion Modified Bufei Yiqi decoction combined with budesonide has significant efficacy in the treatment of child patients with bronchial asthma, and it can effectively improve the clinical symptoms and enhance the lung function of child patients. Related Articles | Metrics

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A 4-year clinical observation on the permanent tooth caries in 12-year old students from 12 middle schools in Shenyang CONG Fang,XU Chang,CONG Bei,HUANG Yue 2019, 11 (5):  419-422.  doi: 10.3969/j.issn.1674-3865.2019.05.013 Abstract ( 907 )   PDF (426KB) ( 110 )   Save Objective To promote the appropriate technologies for oral health care in schools, to carry out oral health screening and analyze the data on permanent tooth caries, and to provide dental and periodontal services for students in order to ensure the physical and psychological development of the children and provide evidence for the sustainable development of oral health in schools. Methods The samples were from Shenyang Stomatology Hospital and Huanggu District Dental Clinic of Shenyang. With reference to the Basic Methods of Oral Health Survey (5th edition) recommended by WHO and the Examination Methods in Oral Health Survey issued by National Health Commission in 2015, clinical examination of teeth was performed in 12-year old students of grade one in middle schools, and the samples were collected. The 4-year research data were accumulated. Results The survey results from 2015 to 2019 showed that there was a decrease in the incidence of caries year by year, and the trend testing was of statistical significance (P<0.05). The results also showed that the mean DMFT was decreased year by year, and the caries filling rate was increased year by year, the trend testing being of statistical significance (P<0.05). The filling rate of new caries at school was 0 in 2019, and compared with that in 2009, there was statistical difference (P<0.05). Conclusion The promotion and implementation of oral health care measures in urban shools by Shenyang Stomatology Hospital plays a significant role in the decrease of the incidence of permanent tooth caries. However, the highrisk population is still the focus of prevention. The treatment and the filling at school are unable to meet the demand of students and their parents, and the risk of cross infection can't be avoided. Therefore, it is necessary to go to the professional dental institutions for clinical treatment. Related Articles | Metrics

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Clinical effect of new pulp capping materials in pulpotomy for primary molars with deep caries XIANG Shanshan，Cong Fang 2019, 11 (5):  422-425.  doi: 10.3969/j.issn.1674-3865.2019.05.014 Abstract ( 553 )   PDF (467KB) ( 94 )   Save Objective To evaluate the clinical effect of iROOT BP Plus in pulpotomy for primary molars with deep caries. Methods A total of 60 children with deep caries in primary molars were chosen, who received treatment in Shenyang Sixth People's Hospital from March 2017 to March 2018, and they were randomly divided into 3 groups based on the pulp-capping agent: iRooT BP Plus group, MTA group and VITAPEX group,20 cases in each group. The three agents were respectively used in pulpotomy. The operation time and the success rate at 3,6 and 12 months after operation were compared among the 3 groups. Results The operation time of group VITAPEX was the shortest, and the operation time of group MTA was the longest, there being significant difference among the three groups（P＜0.05）. Twelve months after treatment, there was one lost case respectively in iROOT BP Plus group and MTA group; there was no significant difference in success rate between iROOT BP Plus group and MTA group（P＞0.017）,but the success rate of iROOT BP Plus group and MTA group was significantly higher than that of VITAPEX group（P≤0.017）. Conclusion The short-term clinical effect of iROOT BP Plus in pulpotomy for primary molars with deep caries is similar to that of MTA. It has a broader prospect in the application of pulp preservation. Related Articles | Metrics

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Diagnostic value of clinical testing for children with Mycoplasma pneumoniae infection SHANG Yan 2019, 11 (5):  426-428.  doi: 10.3969/j.issn.1674-3865.2019.05.015 Abstract ( 470 )   PDF (321KB) ( 98 )   Save Objective To explore the diagnostic value of clinical testing in the treatment of children with Mycoplasma pneumoniae infection. Methods A total of 90 children with Mycoplasma pneumoniae infection admitted to the Children's Hospital of Zhengzhou University from March 2017 to November 2018 were selected as observation group. Meanwhile,90 children receiving health examination in our hospital were selected as the control group. The blood of the two groups of children was collected for testing. The serum immunoglobulin, erythrocyte immune status and peripheral T lymphocyte subsets were analyzed and compared. Results There was no significant difference in IgG levels between the two groups(P>0.05). The level of IgM in the observation group was significantly higher than that in the control group, while the level of IgA was significantly lower, the difference being statistically significant(P<0.05). The RBCICR, immune adhesion promoting factor and RBC-C3bR in the observation group were significantly lower than those in the control group, while the immunoadhesive inhibitory molecules were significantly higher, the difference being statistically significant(P<0.05). CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly lower than those in the control group, while CD8+ was significantly higher, and the difference was statistically significant(P<0.05). Conclusion The immune function of the children with Mycoplasma pneumoniae infection is affected. The serum immunoglobulin, erythrocyte immune status and peripheral blood T lymphocyte status of these children are lower than those of healthy children. Therefore, the children's immune function should be paid attention to during treatment. Related Articles | Metrics

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Effect of Xiyanping injection on intestinal mucosal barrier and myocardial enzyme spectrum level in children with rotavirus diarrhea CHEN Guangyuan 2019, 11 (5):  429-431.  doi: 10.3969/j.issn.1674-3865.2019.05.016 Abstract ( 519 )   PDF (374KB) ( 76 )   Save Objective To investigate the effect of Xiyanping injection on intestinal mucosal barrier and myocardial enzyme spectrum level in children with rotavirus diarrhea. Methods Ninety children with rotavirus diarrhea admitted to our hospital from March 2018 to March 2019 were randomly divided into control group and observation group, 45 cases in each group. The control group was treated with routine treatment, while the observation group was treated with Xiyanping injection on the basis of the treatment for control group. The therapeutic effect, intestinal mucosal barrier function index and myocardial enzyme spectrum level were compared between the two groups. Results The clinical total effective rate of observation group was 95.6%(43/45), which was significantly higher that of control group(80.0%,36/45), the difference being significant(P<0.05). After treatment, compared with the control group, endotoxin(ET), diamine oxidase(DAO), D-lactic acid(D-LAC), phosphocreatine kinase isoenzyme(CK-MB), phosphocreatine kinase(CK), aspartate aminotransferase(AST) and lactate dehydrogenase(LDH) in the observation group decreased, and the difference was statistically significant(P<0.05). Conclusion Xiyanping injection is effective in treating rotavirus diarrhea in children.It can effectively regulate the intestinal mucosal barrier,improve the level of myocardial enzymes,and benefit the prognosis of children with rotavirus diarrhea. Related Articles | Metrics

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Clinical observation on the efficacy of ketogenic diet in the treatment of refractory seizures in children with different causes and seizure forms LIU Wei，QU Xiaojin，GUAN Tongzhen，LIANG Meng 2019, 11 (5):  432-434.  doi: 10.3969/j.issn.1674-3865.2019.05.017 Abstract ( 587 )   PDF (335KB) ( 94 )   Save Objective To analyze the difference in the effect of ketogenic diet in the treatment of refractory epilepsy in children with different causes and seizure forms. Methods From November 2017 to November 2018, 50 patients with refractory epilepsy were treated with ketone-producing diet in our hospital and they were selected as the observation subjects, and were grouped according to different causes and seizure forms. According to the etiology, there were 25 cases in the epilepsy group with unknown cause and 25 cases in the symptomatic epilepsy group. According to the seizure form, there were 20 cases in the mixedseizure epilepsy group and 30 cases in the single-seizure epilepsy group. According to the different types of seizures, there were 10 cases in the epileptic spasm group and 40 in the nonepileptic spasm group. The ketogenic diet was started when the blood ketone was 2 mmol/L. At the same time, potassium bromate is administered, 0.5 g per day, and the compound vitamin mineral preparation was given at 6 g per day. The ratio of the fat in ketogenic diet to the protein and the carbohydrate was 4∶1 or 3∶1. The treatment time was more than 3 months, and the treatment effect was observed. Results The total effective rate of the patients in symptomatic epilepsy group was 80.0%(20/25), which was significantly higher than that of the epilepsy group with unknown cause(48.0%,12/25), and the difference was statistically significant(P<0.05). There was no significant difference in the total effective rate between the single-episode epilepsy group and the mixed-onset epilepsy group(P>0.05). The total effective rate of the epileptic spasm group was 80.0%(8/10), which was significantly higher than that of the non-epileptic spasm group(45.0%,18/40), and the difference was significant(P<0.05). Conclusion Ketogenic diet has high application value in the treatment children with refractory epilepsy. Here in this study it proved that the effect of ketogenic diet has no significant difference in epilepsy children with different seizure forms. The diet has better effect on the children with symptomatic epilepsy and the children with epileptic spasm. Related Articles | Metrics

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Clinical Analysis of 32 children with reversible splenial lesion syndrome and literature review NAN Zaiyuan，WANG Chunyu，ZHANG Zhe，WANG Linlin，HAO Yanqiu 2019, 11 (5):  435-437.  doi: 10.3969/j.issn.1674-3865.2019.05.018 Abstract ( 519 )   PDF (361KB) ( 107 )   Save Objective To explore the clinical features of children with reversible splenial lesion syndrome and to improve the understanding of the diseases. Methods A total of 32 children hospitalized in Harbin Children's Hospital from Jan. 1,2016 to June 30,2018 were included, whose MRI examination suggested that they had splenial lesion. Clinical data, laboratory examination, imaging data and follow-up data of them were analyzed retrospectively. Results Among the 32 children, 17 were male and 15 were female. There were 22 infants and 10 children and adolescents. Of these children, 23 cases started with gastrointestinal symptoms, 5 cases with intracranial infection, and 4 cases with simple convulsion as the first symptom. There were 28 cases of viral infection and 4 cases of bacterial infection. Only splenium of corpus callosum was involved in 30 cases, while in two cases both the splenium and genu of corpus callosum and thalamus were involved. The clinical symptoms of 29 cases were relieved within 1 week, and the splenial lesion disappeared within 2 weeks after the MRI review. No lesion was found in two cases with previous CT of head. Conclusion Patients with gastrointestinal symptoms in early childhood, accompanied by convulsion symptoms, and viral infection as the main pathogen should be highly suspected of reversible splenial lesion syndrome. Even there were no lesions been found in the CT, it is also necessary to use the MRI. Related Articles | Metrics

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Experience in the diagnosis and treatment of acute epididymitis in children REN Guangming 2019, 11 (5):  438-440.  doi: 10.3969/j.issn.1674-3865.2019.05.019 Abstract ( 533 )   PDF (422KB) ( 108 )   Save Acute epididymitis in children is one of the disease of acute scrotal pain, which is classified as "carbuncle" in traditional Chinese medicine; it is not commonly reported clinically. The disease has a rapid onset with obvious pain, so it should be distinguished in time from torsion of testicles and appendages.The delay in diagnosis and treatment may affect fertility. The diagnosis and treatment of this disease should focus on traditional Chinese medicine, and be based on heart and liver, which can significantly improve pain and clinical symptoms in children. Related Articles | Metrics

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Clinical study on the correlation between map tongue and allergic constitution in children PENG Feng 2019, 11 (5):  440-442.  doi: 10.3969/j.issn.1674-3865.2019.05.020 Abstract ( 645 )   PDF (395KB) ( 131 )   Save Objective To explore the clinical correlation between map tongue and allergic constitution in children. Methods According to the selection criteria of allergic constitution，the children in Xiangyang Hospital of Traditional Chinese Medicine were screened from March 2014 to December 2017,and 245 children with allergic constitution and 283 children with nonallergic constitution in the control group were collected. The percentage of children with map tongue and the percentage of the area of map tongue exfoliation in each group were analyzed statistically. Results The HardyWeinberg equilibrium law detection was performed in the two groups of children, and they were in accordance with the HardyWeinberg equilibrium law(P>0.05)，indicating that the observed population was representative of the group. There were 72 children with map tongue in allergic constitution group (29.39% ,72/245) and 39 children with map tongue in control group(13.78% ,39/283)， and the incidence in allergic constitution group was significantly higher than that in nonallergic constitution group(P<0.05). There was no significant difference between the two groups in the exfoliation area of tongue(P>0.05). Conclusion There is a correlation between map tongue and allergic constitution in children. The incidence of map tongue in children with allergic constitution is higher than that in children with nonallergic constitution. Related Articles | Metrics

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Clinical observation of lacrimal sac massage combined with tobramycin eye drops for children with dacryocystitis XING Xiaoqing 2019, 11 (5):  443-445.  doi: 10.3969/j.issn.1674-3865.2019.05.021 Abstract ( 490 )   PDF (444KB) ( 106 )   Save Objective To investigate the effects of lacrimal sac massage combined with tobramycin eye drops on clinical symptoms and complications in children with dacryocystitis. Methods Eighty-four children with dacryocystitis who were treated in our hospital from August 2016 to August 2018 were randomly divided into observation group and control group. The control group was treated with tobramycin eye drops, and the observation group was treated with lacrimal sac massage combined with tobramycin eye drops. The clinical efficacy, the improvement time of symptoms during the treatment(recession of tears, pus) and complications（lacrimal sac swelling and eye infection） were compared between the two groups. Results At the end of the treatment, the total effective rate of the observation group was 97.6%(41/42), which was significantly higher than that of the control group(80.9%,34/42). The difference was statistically significant(P<0.05). The improvement time of symptoms of tears and pus in the observation group was significantly shorter than that of the control group, and the difference was statistically significant(P<0.05). During the treatment, there were 3 cases of lacrimal sac swelling and 1 case of ocular infection in observation group, and 1 case of lacrimal sac swelling in the control group. There was no significant difference in the incidence of complications between the two groups (P>0.05). Conclusion The lacrimal sac massage combined with tobramycin eye drops has a significant clinical effect on children with dacryocystitis, which can effectively shorten the improvement time of clinical symptoms and reduce complications. Related Articles | Metrics

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Intervention effect of the clinical nursing path and the prognosis of children receiving strabismus correction under general anesthesia HOU Mingming，WANG Lifeng 2019, 11 (5):  446-448.  doi: 10.3969/j.issn.1674-3865.2019.05.022 Abstract ( 426 )   PDF (371KB) ( 83 )   Save Objective To explore the intervention effect of the clinical nursing path and the prognosis of children receiving strabismus correction under general anesthesia. Methods Totally 70 cases of children receiving strabismus correction under general anesthesia in our hospital from October 2017 to December 2018 were selected as study subjects, and they were divided into observation group(35 cases) and control group(35 cases) according to the order of admission. The control group was given routine nursing intervention, and the observation group was given comprehensive nursing intervention. The scores of adverse emotions and adverse reactions before and after nursing were compared between the two groups. Results Before nursing intervention, HAMA score and HAMD score of children in the two groups showed no significant difference(P>0.05). After nursing intervention, HAMA score and HAMD score in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05). The incidence of adverse reactions in the observation group was 8.57%(3/35), significantly lower than that in the control group(34.29%,12/35), with statistically significant difference(P<0.05). Conclusion In the nursing care of children receiving strabismus correction under general anesthesia, the implementation of comprehensive nursing intervention can effectively help children to relieve adverse emotions and reduce adverse reactions, and nursing effect is significant,so it is worth promoting. Related Articles | Metrics

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Effect of early rehabilitation nursing on dysphagia in children with severe viral encephalitis WU Yingying，SHANG Qing，ZHANG Qingmei 2019, 11 (5):  449-451.  doi: 10.3969/j.issn.1674-3865.2019.05.023 Abstract ( 440 )   PDF (394KB) ( 114 )   Save Objective To analyze the effect of early rehabilitation nursing on dysphagia in children with severe viral encephalitis. Methods A total of 110 children with severe viral encephalitis with dysphagia treated in the Children's Hospital of Henan Province from April 2018 to February 2019 were included as the research subjects. According to the order of admission, they were divided into 55 cases in the control group and 55 cases in the observation group. The control group received routine nursing, and the observation group was given early rehabilitation nursing, such as swallowing ability training (pharyngeal cold stimulation training, tongue muscle resistance training, lip muscle training, mouth exercise training), feeding training and language training, continuously for 3-5 courses with 10 days as one course. Observe the total clinical effective rate, the incidence of complications, and the satisfaction with nursing services. Results (1) The total effective rate of nursing in the observation group was 98.1%(54/55), which was significantly higher than the 83.6%(46/55) in the control group. The difference between the two groups was statistically significant (P<0.05); (2) The incidence rate of the observation group(3.6%,2/55) was lower than that of the control group(16.36%,9/55)(P<0.05). The difference was statistically significant (P<0.05).(3)The satisfaction degree of nursing was 100%(55/55) in the observation group, which was significantly higher than the control group(90.9%,50/55), and the difference was statistically significant(P<0.05). Conclusion Early rehabilitation nursing for children with severe viral encephalitis accompanied by dysphagia is effective and worth promoting. Related Articles | Metrics

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Evaluation on the value of sedative nursing in pediatric ICU JIN Lingyun 2019, 11 (5):  452-454.  doi: 10.3969/j.issn.1674-3865.2019.05.024 Abstract ( 478 )   PDF (384KB) ( 99 )   Save Objective To evaluate the application value of sedation nursing in pediatric intensive care unit. Methods A total of 100 patients in pediatric intensive care unit admitted to Zhengzhou Children's Hospital from February 2013 to February 2015 were selected as research subjects and they were randomly divided into control group and observation group with 50 cases in each group. The control group received routine nursing while the observation group received sedation nursing. The observation indexes were the sleep state and awake state of the children on the 5th, 10th and 15th days after receiving nursing intervention, and the children were scored by using a sedation score table (Ram-say). Results The Ram-say score of the observation group was significantly higher than that of the control group on the 5th, 10th and 15th days, and the difference was statistically significant (P<0.05). Conclusion Sedation nursing is helpful for children in intensive care unit to be quiet quickly, to receive better treatment and to recover as soon as possible. Related Articles | Metrics

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A summary of professor Shi Yumin's experience in the treatment of infectious myositis in children by nourishing Yin and tonifying kidney SUN Yanyan，WANG Yonghong，SHI Yumin 2019, 11 (5):  454-457.  doi: 10.3969/j.issn.1674-3865.2019.05.025 Abstract ( 568 )   PDF (609KB) ( 73 )   Save Infectious myositis in children is characterized by weak muscle strength, pain and secondary muscular atrophy, which belongs to the category of Wei syndrome in traditional Chinese medicine according to its clinical manifestation. It is proposed in Nei Jing Wei Lun to "cure impotence only by taking yangming". According to the physiological and pathological characteristics of children, professor Shi Yumin believes that heat injury in Qi Yin and dystrophy of muscle and vessel is the main pathogenesis of Wei syndrome. Pathogenic heat and fluid injury is the external performance, while spleen and kidney deficiency is the internal cause. Therefore, the method of nourishing Yin and tonifying kidney is used to treat infantile infectious myositis, and the effect is remarkable. Through combination with case analysis, this paper summarizes the experience of professor Shi in treating children with Wei syndrome. Related Articles | Metrics

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Learning from mentor about diagnosis and treatment of dwarfism——some clinical thoughts LEI Huan, WAN Ying 2019, 11 (5):  458-460.  doi: 10.3969/j.issn.1674-3865.2019.05.026 Abstract ( 491 )   PDF (492KB) ( 79 )   Save This paper mainly summarizes the teacher Wan Ying's clinical experience in treating dwarfism in children and the author's clinical understanding. The treatment should be based on the pathophysiological characteristics of children and the concept of "spleen and kidney are the basis of human beings"， hoping to be more experienced in the diagnosis and treatment of dwarfism in children in the future. Related Articles | Metrics