基于核因子-κB探究肾驻留细胞在狼疮性肾炎中的作用机制

doi:10.20274/j.cnki.issn.1674-3865.2025.05.007

Abstract

Abstract:

Lupus nephritis (LN) is an immunocomplex nephritis caused by systemic lupus erythematosus (SLE) involving the kidneys. The main manifestation of LN is the deposition of autoantibodies and their immunocomplexes in the kidneys, which triggers a chronic inflammatory infiltration and the gradual destruction of the structure and function of the kidneys. The renal resident cells play a crucial role in this process. Recent studies have shown that nuclear factor-kappa B (NF-κB) can regulate the gene expression of multiple cytokines, growth factors and adhesion molecules in the progression of inflammation, such as the expression of monocyte chemoattractant protein-1 and granulocyte-macrophage colony-stimulating factors in mesangium and glomerular epithelial cells. NF-κB is closely related to the development of LN and plays a unique role in targeting and regulating the biological responses of renal resident cells, including renal mesangial cells, podocytes and tubular epithelial cells. Against this background, this article reviews the relationship between NF-κB and renal resident cells and their role in the pathogenesis of LN, with an aim to gain a deeper understanding of the underlying cellular and molecular mechanisms involved in LN and provide theoretical references for application in LN prevention and treatment.

Key words: Lupus nephritis, NF-κB pathway, Renal resident cells, Mechanism of action

CLC Number:

R593.24+2

Hongxun HUANG, Weiwei LI. Study on the mechanism of action of renal resident cells in lupus nephritis based on NF-κB[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(5): 397-401.

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Study on the mechanism of action of renal resident cells in lupus nephritis based on NF-κB

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