关键词: 极低出生体重儿, 冰冻血浆, 肺出血, 低血糖, 颅内出血, 早产儿

Abstract:
Objective
To summarize the clinical efficacy of fresh frozen plasma treatment for very-low-birth-weight infant.
Methods
A total of 162 cases of premature babies were included in the study, who were treated in Neonatology Departments of Linxia People's Hospital between January 2013 and November 2015. The 72 children who were hospitalized between Jan. 2013 to Jan. 2014 were chosen as the control group, and the 90 children from Feb. 2014 to Nov. 2015 as the observation group. The control group was given the treatment of maintaining blood sugar, preventing infection, promoting lung mature and feeding properly, while the observation group was treated by venous infusion of fresh frozen plasma, 10～15 mL/kg,3 to 7 times, in addition to the treatment for control group. Observe the incidence of infection, organ bleeding, feeding intolerance, hypoglycemia, multiple organ failure, phototherapy duration, length of hospital stay and the mortality.
Results
The incidence rate of infection, organ bleeding, feeding intolerance, hypoglycemia, multiple organ failure and the mortality in observation group was lower than that of the control group,and there was statistical difference(P<0.05). The phototherapy duration and length of hospital stay were shorter, compared with the control group, and the difference was statistically significant(P<0.05).
Conclusion
The use of fresh frozen plasma in the treatment of very-low-birth-weight premature infants can reduce the incidence of organ bleeding, infection, feeding intolerance, hypoglycemia, and multiple organ failure. At the same time, there is no transfusion related infectious disease in the observation group, so it is safe and effective.

Key words: VLBW infant, Fresh frozen plasma, Pulmonary hemorrhage, Hypoglycemia, Intracranial hemorrhage, Preterm children